Scientists create mice with a major genetic cause of ALS and FTD
Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease), both of which are caused by a mutation in the a gene called C9ORF72. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - May 22, 2015 Category: Neurology Source Type: news

A SMARTer approach to stroke care
Time is critical when it comes to stroke: early treatment is associated with better outcomes. According to the Screening with MRI for Accurate and Rapid stroke Treatment (SMART) study, small changes in quality improvement procedures enabled clinicians to use MRI scans to diagnose stroke patients before giving acute treatment, within 60 minutes of hospital arrival. MRI scans provide detailed images but take longer to complete than CT scans, which are commonly used in most centers. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - May 13, 2015 Category: Neurology Source Type: news

Scientists unravel the mystery of the tubulin code
Driving down the highway, you encounter ever-changing signs— speed limits, exits, food and gas options. Seeing these roadside markers may cause you to slow down, change lanes or start thinking about lunch. In a similar way, cellular structures called microtubules are tagged with a variety of chemical markers that can influence cell functions. The pattern of these markers makes up the “tubulin code” and according to a paper published in Cell, scientists at NIH’s National Institute of Neurological Disorders and Stroke (NINDS) have uncovered the mechanism behind one of the main writers of this code, tubulin tyrosine l...
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - May 12, 2015 Category: Neurology Source Type: news

Study points to possible treatment for lethal pediatric brain cancer
Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat and similar gene regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), an aggressive and lethal form of pediatric cancer. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - May 4, 2015 Category: Neurology Source Type: news

Drugs that activate brain stem cells may reverse multiple sclerosis in mice
Two drugs already on the market — an antifungal and a steroid — may potentially take on new roles as treatments for multiple sclerosis. According to a study in Nature, researchers discovered that these drugs may activate stem cells in the brain to stimulate myelin producing cells and repair white matter, which is damaged in multiple sclerosis. The study was partially funded by the NIH’s National Institute of Neurological Disorders and Stroke (NINDS). (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - April 20, 2015 Category: Neurology Source Type: news

Drugs that activate brain stem cells may reverse multiple sclerosis
Two drugs already on the market — an antifungal and a steroid — may potentially take on new roles as treatments for multiple sclerosis. According to a study in Nature, researchers discovered that these drugs may activate stem cells in the brain to stimulate myelin producing cells and repair white matter, which is damaged in multiple sclerosis. The study was partially funded by the NIH’s National Institute of Neurological Disorders and Stroke (NINDS). (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - April 20, 2015 Category: Neurology Source Type: news

Strengthening the immune system’s fight against brain cancer
When cancer strikes, it may be possible for patients to fight back with their own defenses, using a strategy known as immunotherapy. According to a new study published in Nature, researchers have found a way to enhance the effects of this therapeutic approach in glioblastoma, a deadly type of brain cancer, and possibly improve patient outcomes. The research was funded by the National Institute of Neurological Disorders and Stroke (NINDS) as well as the National Cancer Institute (NCI), which are part of the National Institutes of Health. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - March 18, 2015 Category: Neurology Source Type: news

Study reveals how genetic changes lead to familial Alzheimer’s disease
Mutations in the presenilin-1 gene are the most common cause of inherited, early-onset forms of Alzheimer’s disease. In a new study, published in Neuron, scientists replaced the normal mouse presenilin-1 gene with Alzheimer’s-causing forms of the human gene to discover how these genetic changes may lead to the disorder. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - March 11, 2015 Category: Neurology Source Type: news

Brain Awareness Week Teaches Children How Their Brains Work
A celebration of the 16th annual Brain Awareness Week (BAW), a worldwide campaign to increase public awareness of the progress and benefits of brain research, will take place March 16-20, 2015, at the National Museum of Health and Medicine in Silver Spring, Maryland. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - March 5, 2015 Category: Neurology Source Type: news

Scientists map memorable tunes in the rat brain
Lights, sound, action: we are constantly learning how to incorporate outside sensations into our reactions in specific situations. In a new study, brain scientists have mapped changes in communication between nerve cells as rats learned to make specific decisions in response to particular sounds. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - March 3, 2015 Category: Neurology Source Type: news

NIH-funded research lays groundwork for next-generation prosthetics
Three groups of researchers who have received support from the National Institutes of Health will obtain funding from the President’s BRAIN Initiative to improve artificial limb technology. The new awards will be funded and administered by the Defense Advanced Research Projects Agency (DARPA) and will build on the fundamental discoveries that were made possible by NIH funding. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - February 9, 2015 Category: Neurology Source Type: news

Paramedics may be first line of treatment for stroke
There is no time to waste when it comes to stroke. The more time that passes between stroke onset and treatment, the worse the outcome is for the patient. A study designed to test the benefits of early administration of magnesium sulfate suggests that stroke patients may not have to wait until they get to the hospital for treatment — paramedics may be able to start therapy as soon as stroke is suspected. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - February 4, 2015 Category: Neurology Source Type: news

New members selected for National Advisory Neurological Disorders and Stroke Council
Five prominent individuals from the neuroscience community have joined the National Advisory Neurological Disorders and Stroke Council, the principal advisory body to the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - January 29, 2015 Category: Neurology Source Type: news

Diaper compound may expand power of microscopes
Pour, mix, set, add water and voila: highly detailed images of the inside of cells. A study, partially funded by the National Institutes of Health (NIH), showed that a modified form of the superabsorbent chemical used in disposable diapers can expand brain structures to four and a half times their original size. The process called expansion microscopy will allow scientists to take superresolution pictures of healthy and diseased tissue throughout the body using lenses of common microscopes. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - January 23, 2015 Category: Neurology Source Type: news

Winners announced in NIH-supported crowdsourcing contest of seizure prediction
As a result of two novel online contests, epilepsy researchers have some new tools to help accurately predict and detect seizures. The contests, supported by the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS), the American Epilepsy Society (AES) and the Epilepsy Foundation, invited members of the public to develop computer algorithms to detect, predict and ultimately prevent epileptic seizures. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - December 16, 2014 Category: Neurology Source Type: news