Study reveals how genetic changes lead to familial Alzheimer’s disease

Mutations in the presenilin-1 gene are the most common cause of inherited, early-onset forms of Alzheimer’s disease. In a new study, published in Neuron, scientists replaced the normal mouse presenilin-1 gene with Alzheimer’s-causing forms of the human gene to discover how these genetic changes may lead to the disorder.

Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - March 11, 2015 Category: Neurology Source Type: news