Veterinary Immunology and Immunopathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The failure of a DNA prime/protein boost regime and CTLA-4 mediated targeting to improve the potency of a DNA vaccine encoding Fasciola hepatica phosphoglycerate kinase in sheep
Publication date: Available online 9 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Wesołowska Agnieszka, Basałaj Katarzyna, Zawistowska-Deniziak Anna, Januszkiewicz Kamil, Kozak Ljunggren Monika, Jedlina Luiza, Wędrychowicz HalinaAbstractDNA vaccination in large animals has often been associated with poor immunogenicity, consequently several approaches have been evaluated to enhance its efficacy. Here, we tested a cDNA encoding a phosphoglycerate kinase from Fasciola hepatica (cDNA-FhPGK/pCMV) as a vaccine against ovine fasciolosis and investigated whether a DNA prime/protein boost regime or ...
Source: Veterinary Immunology and Immunopathology - September 10, 2019 Category: Veterinary Research Source Type: research

Detection of MERS-CoV antigen on formalin-fixed paraffin-embedded nasal tissue of alpacas by immunohistochemistry using human monoclonal antibodies directed against different epitopes of the spike protein
Publication date: Available online 9 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Ann-Kathrin Haverkamp, Berend J. Bosch, Ingo Spitzbarth, Annika Lehmbecker, Nigeer Te, Albert Bensaid, Joaquim Segalés, Wolfgang BaumgärtnerAbstractMiddle East respiratory syndrome (MERS) represents an important respiratory disease accompanied by lethal outcome in one third of human patients. In recent years, several investigators developed protective antibodies which could be used as prophylaxis in prospective human epidemics. In the current study, eight human monoclonal antibodies (mAbs) with neutralizing and ...
Source: Veterinary Immunology and Immunopathology - September 10, 2019 Category: Veterinary Research Source Type: research

Canine multicentric lymphoma exhibits systemic and intratumoral cytokine dysregulation
Publication date: Available online 9 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Joana N.R. Dias, Mariana Lopes, Conceição Peleteiro, Gonçalo Vicente, Telmo Nunes, Luísa Mateus, Frederico Aires-da-Silva, Luís Tavares, Solange GilAbstractNon-Hodgkin Lymphoma (NHL) is among the most common neoplasias in dogs and humans. Owing to remarkable similarities with its human counterpart, the canine lymphoma (cNHL) model has been proposed as a powerful framework for rapid and clinically relevant translation of novel immunotherapies. However, the establishment of cNHL as a predictive preclinical mode...
Source: Veterinary Immunology and Immunopathology - September 10, 2019 Category: Veterinary Research Source Type: research

Immunological response to porcine reproductive and respiratory syndrome virus in young pigs obtained from a PRRSV-positive exposure status herd in a PRRSV endemic area
Publication date: Available online 6 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Nattinee Kittiwan, Panuwat Yamsakul, Pakpoom Tadee, Phacharaporn Tadee, Aniroot Nuangmek, Phongsakorn Chuammitri, Prapas PatchaneeAbstractPorcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), remains a major economic threat to swine production throughout the world. The aim of this study was to investigate the humoral and cell-mediated immune responses to PRRSV in 10 PRRSV vaccinated and 10 non-vaccinated young pigs obtained from a PRRSV-seropositive herd under field conditions. On...
Source: Veterinary Immunology and Immunopathology - September 7, 2019 Category: Veterinary Research Source Type: research

Distribution of regulatory T cells in inflammatory colorectal polyps of Miniature Dachshunds
Publication date: Available online 3 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Keisuke Konishi, Hirotaka Igarashi, Shingo Maeda, Eri Uchida, Kiwamu Hanazono, Takashi Tamamoto, Kazuyuki Uchida, Daiji Endoh, Koichi OhnoAbstractInflammatory colorectal polyp (ICRP) is an emerging disease in Miniature Dachshunds (MDs). Animals with this disease exhibit multiple polyps with severe neutrophil infiltration that respond to immunosuppressive therapy. Macrophages in polypoid lesions have been described to play an important role in neutrophil infiltration in the lesion by producing IL-8. In contrast, IL...
Source: Veterinary Immunology and Immunopathology - September 4, 2019 Category: Veterinary Research Source Type: research

Microalgae supplementation to late gestation sows and its effects on the health status of weaned piglets fed diets containing high- or low-quality protein sources
Publication date: Available online 3 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): A.V. Lee, L. You, S.Y. Oh, Z. Li, R.E. Fisher-Heffernan, T.R.H. Regnault, C.F.M. de Lange, L. Huber, N.A. KarrowAbstractMaternal stress, such as a bacterial infection occurring in late gestation, may predispose offspring to a variety of diseases later in life. It may also alter programming of developing systems within the fetus, such as the hypothalamic-pituitary-adrenal (HPA) axis and immune system. Dietary supplementation during the last trimester of pregnancy with immune-modulating compounds may be a means of r...
Source: Veterinary Immunology and Immunopathology - September 4, 2019 Category: Veterinary Research Source Type: research

Investigating the role of interleukin 10 on Eimeria intestinal pathogenesis in broiler chickens
Publication date: Available online 31 August 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Maria Arendt, Jonathan Elissa, Natalie Schmidt, Emily Michael, Nicole Potter, Mark Cook, Laura J. KnollAbstractEimeria species are intestinal protozoan parasites that cause lack of production, malabsorption and mortality in floor raised chickens. Administering an oral antibody to interleukin 10 (aIL-10) reduces the symptoms of coccidiosis in broilers, indicating interleukin 10 (IL-10) is key to Eimeria pathology. IL-10 is an anti-inflammatory cytokine and acts as a stand down signal to reduce inflammation and host p...
Source: Veterinary Immunology and Immunopathology - September 1, 2019 Category: Veterinary Research Source Type: research

Prevalence and risk factors for the presence of serum antibodies against canine distemper, canine parvovirus, and canine adenovirus in communities in mainland Ecuador
Publication date: Available online 28 August 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Brian A. DiGangi, Patricia A. Dingman, C. Jaime Grijalva, Mark Belyeu, Sylvia Tucker, Ramiro IsazaAbstractThe purpose of this study was to estimate the apparent prevalence and identify risk factors for antibody levels (AL) against canine distemper virus (CDV), canine parvovirus (CPV), and canine adenovirus (CAV) in three communities in the metropolitan area of Quito, Ecuador that have limited access to regular veterinary care. Whole blood samples were collected from 154 dogs presenting to three veterinary field clin...
Source: Veterinary Immunology and Immunopathology - August 28, 2019 Category: Veterinary Research Source Type: research

Ambient ammonia does not appear to inhibit the immune response to infectious bronchitis virus vaccination and protection from homologous challenge in broiler chickens
This study examined the effect of NH3 on the immune response to infectious bronchitis virus (IBV) vaccination and protection against homologous serotype challenge in commercial broiler chickens. One-day-old chicks were administered IBV vaccine and exposed to 30-60 ppm of NH3. At 28 DOA, birds were challenged oculonasally with a pathogenic homologous IBV, and protection was measured by viral detection, clinical signs, ciliostasis, and presence of airsacculitis. IBV-specific serum IgG and lacrimal fluid IgA titers, as well as Harderian gland (HG) immune cell phenotypes, were evaluated. Ammonia exposure was associated with ...
Source: Veterinary Immunology and Immunopathology - August 24, 2019 Category: Veterinary Research Source Type: research

An interferon-gamma release assay for the diagnosis of the Mycobacterium bovis infection in white rhinoceros (Ceratotherium simum)
Publication date: Available online 15 August 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Josephine Chileshe, Eduard O. Roos, Wynand J. Goosen, Peter Buss, Guy Hausler, Leana Rossouw, Tebogo Manemela, Paul van Helden, Robin Warren, Sven DC Parsons, Michele MillerAbstractMycobacterium bovis (M. bovis), the cause of bovine tuberculosis, is endemic in Kruger National Park (KNP), South Africa. The risk of spread of M. bovis infection currently prevents translocation of white rhinoceros (Ceratotherium simum) from this population. Therefore, accurate assays are necessary for screening this threatened species. ...
Source: Veterinary Immunology and Immunopathology - August 16, 2019 Category: Veterinary Research Source Type: research

Potential of the dual IFN-γ/IL-2 fluorescence-immunospot assay to distinguish different stages in bovine tuberculosis
In conclusion, our FluoroSpot is a valid method to enumerate individual antigen-specific IFN-γ+ and IL-2+ T cell subsets ex vivo. The greater levels of single IL-2 producing T cells associated with the presence of pathology could be a potential biomarker for active TB in cattle. (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - August 14, 2019 Category: Veterinary Research Source Type: research

Editorial Board
Publication date: September 2019Source: Veterinary Immunology and Immunopathology, Volume 215Author(s): (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - August 13, 2019 Category: Veterinary Research Source Type: research

Effect of FMD vaccination schedule of dams on the level and duration of maternally derived antibodies
Publication date: Available online 11 August 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): B. Sareyyüpoğlu, V. Gülyaz, C. Çokçalışkan, Y. Ünal, T. Çökülgen, E. Uzunlu, S. Gürcan, O. İlkAbstractVaccination against Foot and Mouth Disease (FMD) in pregnant cows is crucial to produce greater immunity in new born calves, especially in late gestation, as this directly affects neonatal immunity. Therefore, we aimed to investigate how late gestation FMD vaccination of pregnant cows affects the maternally derived antibodies in their offspring. Pregnant cows were vaccinated with and without booster vac...
Source: Veterinary Immunology and Immunopathology - August 12, 2019 Category: Veterinary Research Source Type: research

Effect of Mycoplasma bovis on expression of inflammatory cytokines and matrix metalloproteinases mRNA in bovine synovial cells
In this study, we examined the immunologic response of bovine synovial tissue to M. bovis. We observed significant increases in expression of interleukin (IL)-1β, IL-6, IL-8, MMP-1, and MMP-3 mRNA in synovial tissue from Mycoplasma arthritis calves compared with tissues from normal calves. Expression of IL-6, IL-8, and MMP-1 mRNA was also induced in cultured synovial cells stimulated with M. bovis, but not expression of IL-1β and MMP-3 mRNA. In contrast, the culture supernatant of peripheral blood mononuclear cells stimulated with M. bovis induced marked increases in the expression of IL-1β, IL-6, IL-8, MMP-1, and MMP-3...
Source: Veterinary Immunology and Immunopathology - August 9, 2019 Category: Veterinary Research Source Type: research

Genetic polymorphisms in Toll-like receptors 1, 2, and 4 in feline upper respiratory tract aspergillosis
Publication date: Available online 7 August 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): J. Whitney, B. Haase, J. Beatty, V.R. BarrsAbstractFungal species in the genus Aspergillus are environmental saprophytes that can act as opportunistic pathogens of the nasal cavity and paranasal sinuses in humans, cats and other species. Upper respiratory tract aspergillosis (URTA) presents as non-invasive and invasive forms with the latter occurring almost exclusively in immunocompromised hosts. However, in domestic cats, invasive URTA affects apparently immunocompetent patients. A defect in innate immunity has been...
Source: Veterinary Immunology and Immunopathology - August 9, 2019 Category: Veterinary Research Source Type: research