Will the real long QT genes please stand up
Our understanding of the genetic landscape for inherited long QT syndrome (LQTS) has evolved since the first discovery of the molecular basis of LQT1-3 in 1995 [1 –3]. With rapid advances in technology, particularly large-scale next generation sequencing, there has been haste to discover the “next” LQTS gene. This has led to a rapid expansion of the list of so-called LQTS genes to at least 16 genes, many without any strong functional or linkage data to support pathogenicity [4]. As population datasets have grown to the current size [more than 138,000 exomes and genomes in the gnomAD database (gnomAD.broadinstitute.or...
Source: Trends in Cardiovascular Medicine - April 16, 2018 Category: Cardiology Authors: Belinda Gray, Christopher Semsarian Source Type: research
Use of Software Applications to Improve Medication Adherence and Achieve More Integrated Disease Management in Heart Failure A Review
The treatment and management of heart failure is associated with high mortality rates and treatment costs. Poor medication adherence is a major barrier to improving care and traditional interventions addressing non-adherence have not consistently demonstrated improvement in health care outcomes like readmission. The reasons for non-adherence are complicated and illustrate the broader challenges patients face when managing a complex disease like heart failure. In this review, a digitally enabled heart failure management platform consisting of medical digital tools and software solutions that are designed to be patient-facin...
Source: Trends in Cardiovascular Medicine - April 16, 2018 Category: Cardiology Authors: Guy Talmor, Benjamin Nguyen, Andrew Keibel, Tijana Temelkovska, Leslie Saxon Source Type: research
Will the real long qt genes please stand up
Our understanding of the genetic landscape for inherited long QT syndrome (LQTS) has evolved since the first discovery of the molecular basis of LQT1-3 in 1995 [1-3]. With rapid advances in technology, particularly large-scale next generation sequencing, there has been haste to discover the “next” LQTS gene. This has led to a rapid expansion of the list of so-called LQTS genes to at least 16 genes, many without any strong functional or linkage data to support pathogenicity [4]. As population datasets have grown to the current size [more than 138,000 exomes and genomes in the gnomAD database (gnomAD.broadinstitute.org) ...
Source: Trends in Cardiovascular Medicine - April 16, 2018 Category: Cardiology Authors: Belinda Gray, Christopher Semsarian Source Type: research
Contemporary Approach to Stroke Prevention in Atrial Fibrillation: Risks, Benefits, And New Options
Atrial fibrillation is a common diagnosis affecting nearly 3 million adults in the United States. Morbidity and mortality in these patients is driven largely by the associated increased risk of thromboembolic complications, especially stroke. Atrial fibrillation is a stronger risk factor than hypertension, coronary disease, or heart failure and is associated with an approximately five-fold increased risk. Mitigating stroke risk can be challenging and requires accurate assessment of stroke risk factors and careful selection of appropriate therapy. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - April 4, 2018 Category: Cardiology Authors: Jonathan Stock, Brian J. Malm Source Type: research
The genetic architecture of long QT syndrome: A critical reappraisal
Collectively, the completion of the Human Genome Project and subsequent development of high-throughput next-generation sequencing methodologies have revolutionized genomic research. However, the rapid sequencing and analysis of thousands upon thousands of human exomes and genomes has taught us that most genes, including those known to cause heritable cardiovascular disorders such as long QT syndrome, harbor an unexpected background rate of rare, and presumably innocuous, non-synonymous genetic variation. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 30, 2018 Category: Cardiology Authors: John R. Giudicessi, Arthur A.M. Wilde, Michael J. Ackerman Source Type: research
The Genetic Architecture of Long QT Syndrome: A Critical Reappraisal
Collectively, the completion of the Human Genome Project and subsequent development of high-throughput next-generation sequencing methodologies have revolutionized genomic research. However, the rapid sequencing and analysis of thousands upon thousands of human exomes and genomes has taught us that most genes, including those known to cause heritable cardiovascular disorders such as long QT syndrome, harbor an unexpected background rate of rare, and presumably innocuous, non-synonymous genetic variation. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 30, 2018 Category: Cardiology Authors: John R. Giudicessi, Arthur A.M. Wilde, Michael J. Ackerman Source Type: research
Nox2: A new challenge for antiplatelet treatment?
The functional interplay between reactive oxidant species (ROS) and platelet activation was originally demonstrated by Del Principe et al. [1], who used H2O2 as a stimulus to aggregate platelets. H2O2–mediated platelet aggregation occurred via calcium mobilization and enhanced thromboxane(Tx) A2 biosynthesis, an effect blunted if platelets were incubated with catalase, an enzyme that destroys H2O2 [2]. The inhibitory effect of other antioxidants such as vitamin C and E confirmed intra-platelet redox status as an important factor modulating platelet aggregation (PA) [3]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 27, 2018 Category: Cardiology Authors: Francesco Violi Tags: Editorial Source Type: research
Nox2: a new challenge for antiplatelet treatment?
The functional interplay between reactive oxidant species (ROS) and platelet activation was originally demonstrated by Del Principe et al. [1], who used H2O2 as a stimulus to aggregate platelets. H2O2 –mediated platelet aggregation occurred via calcium mobilization and enhanced thromboxane(Tx) A2 biosynthesis, an effect blunted if platelets were incubated with catalase, an enzyme that destroys H2O2 [2]. The inhibitory effect of other antioxidants such as vitamin C and E confirmed intra-platelet redox status as an important factor modulating platelet aggregation(PA) [3]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 27, 2018 Category: Cardiology Authors: Francesco Violi Source Type: research
NADPH oxidase 2 (NOX2): A key target of oxidative stress-mediated platelet activation and thrombosis
Oxidative stress represents an imbalance between the production of reactive oxygen species (ROS) and the cellular antioxidant system. Increased levels of oxidative stress contribute to the development of atherosclerosis that eventually leads to thrombosis; a principle cause of heart attacks and strokes. Thrombosis is a consequence of platelet activation and aggregate formation within the circulation. Platelet ROS are mostly generated by reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 26, 2018 Category: Cardiology Authors: Eduardo Fuentes, Jonathan M. Gibbins, Lisa M. Holbrook, Iv án Palomo Source Type: research
Nadph Oxidase 2 (Nox2): A Key Target of Oxidative Stress-Mediated Platelet Activation and Thrombosis
Oxidative stress represents an imbalance between the production of reactive oxygen species (ROS) and the cellular antioxidant system. Increased levels of oxidative stress contribute to the development of atherosclerosis that eventually leads to thrombosis; a principle cause of heart attacks and strokes. Thrombosis is a consequence of platelet activation and aggregate formation within the circulation. Platelet ROS are mostly generated by reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 26, 2018 Category: Cardiology Authors: Eduardo Fuentes, Jonathan M. Gibbins, Lisa M. Holbrook, Iv án Palomo Source Type: research
Are cytokines ready for prime time? Insights from markers and trials
Cardiovascular (CV) disease remains a leading source of morbidity and mortality worldwide. Over recent decades, it has become apparent that clinical risk factors alone do not neatly capture the individual risk profile for future CV events. This unmet need has created an impetus for the discovery of biomarkers reflective of the underlying disease pathophysiology that can provide a personalized approach to risk stratification and risk modification. An additional value of biomarker discovery is that they do not just track a response to therapy but can potentially suggest novel therapeutic targets. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 20, 2018 Category: Cardiology Authors: Andriana P. Nikolova, Robin M. Shaw Tags: Editorial Source Type: research
Are Cytokines Ready for Prime Time? Insights from Markers and Trials
Cardiovascular (CV) disease remains a leading source of morbidity and mortality worldwide. Over recent decades, it has become apparent that clinical risk factors alone do not neatly capture the individual risk profile for future CV events. This unmet need has created an impetus for the discovery of biomarkers reflective of the underlying disease pathophysiology that can provide a personalized approach to risk stratification and risk modification. An additional value of biomarker discovery is that they do not just track a response to therapy but can potentially suggest novel therapeutic targets. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 20, 2018 Category: Cardiology Authors: Andriana P. Nikolova, Robin M. Shaw Source Type: research
Editorial Board
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 13, 2018 Category: Cardiology Source Type: research
Diagnosing spontaneous coronary artery dissection in women: A call for early coronary angiography
There is a unique cohort of patients, predominantly women, that experience chest pain or acute coronary syndromes in the absence of significant epicardial coronary artery disease. These individuals present with signs and symptoms consistent with ischemia and undergo a diagnostic evaluation with the objective of identifying atherosclerotic coronary disease as the causal factor. When these studies find no or insignificant ( (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 13, 2018 Category: Cardiology Authors: Jane A. Leopold Tags: Editorial Source Type: research
