Nox2: A new challenge for antiplatelet treatment?
The functional interplay between reactive oxidant species (ROS) and platelet activation was originally demonstrated by Del Principe et al. [1], who used H2O2 as a stimulus to aggregate platelets. H2O2–mediated platelet aggregation occurred via calcium mobilization and enhanced thromboxane(Tx) A2 biosynthesis, an effect blunted if platelets were incubated with catalase, an enzyme that destroys H2O2 [2]. The inhibitory effect of other antioxidants such as vitamin C and E confirmed intra-platelet redox status as an important factor modulating platelet aggregation (PA) [3].
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Francesco Violi Tags: Editorial Source Type: research