Cerebral protection devices during transcatheter aortic valve implantation
Transcatheter Aortic Valve Implantation (TAVI) in patients with aortic valve stenosis is associated with an improvement of clinical outcomes, quality of life and self-sufficiency. The most feared TAVI related complication is the occurrence of stroke. In order to reduce peri-procedural cerebral embolizations, diverse cerebral protection devices have been developed. These devices work though deflection or filtering of emboli, and are in different stages of testing. Silent cerebral infarctions identified by diffusion weighted magnetic resonance imaging (DW-MRI) are used as surrogate primary outcomes, but the clinical signific...
Source: Trends in Cardiovascular Medicine - February 2, 2018 Category: Cardiology Authors: Wieneke Vlastra, Jeroen Vendrik, Karel T. Koch, Jan Baan, Jan J. Piek, Ronak Delewi Source Type: research
The Lower the LDL the Better but How and How Much?
In this issue of Trends in Cardiovascular Medicine, in a comprehensive review, Packard concludes that the lower the level of low-density lipoprotein cholesterol (LDL), the better [1]. This finding should be viewed in the context of the totality of evidence. In descriptive studies, useful to formulate, but not test, hypotheses, before the introduction of western lifestyles, the majority of the adult population of the world had LDLs of about 50 mg per deciliter (mg/dL). Japan has had the longest life expectancy in the world as well as the history of the world, due mainly to very low rates of coronary heart disease (CHD). (So...
Source: Trends in Cardiovascular Medicine - February 2, 2018 Category: Cardiology Authors: Alexander Gitin, Marc A. Pfeffer, Charles H. Hennekens Source Type: research
Emerging concepts in diagnosis and treatment of syncope by pacing
Neuroendocrine syncope is a newly proposed term to embody both syncope of reflex and adenosine-related etiology. Recent publications on tilt testing have revealed the presence of a hypotensive tendency in some patients, even in the face of severe cardioinhibition. This new understanding may allow better selection of older reflex syncope patients, documented by ECG loop recorder, for successful pacing where tilt testing is ideally negative for a good result in terms of few syncope recurrences and prompts a less aggressive management policy when hypotensive medication is required. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - February 2, 2018 Category: Cardiology Authors: Richard Sutton, Jean-Claude Deharo, Michele Brignole, Mohamed H. Hamdan Source Type: research
Editorial commentary: Novel developments in revascularization for left main coronary artery disease
In this issue of Trends in Cardiovascular Medicine, Akodad and Morice provide a review of left main (LM) coronary artery disease [1]. The authors discuss the anatomy and pathophysiology of LM disease, the technical considerations for LM percutaneous coronary intervention (PCI), and the latest research and most influential studies of PCI versus coronary artery bypass grafting (CABG) in LM disease. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 17, 2018 Category: Cardiology Authors: Edward T. Carreras, Deepak L. Bhatt Source Type: research
Novel Developments in Revascularization for Left Main Coronary Artery Disease
In this issue of Trends in Cardiovascular Medicine, Akodad and Morice provide a review of left main (LM) coronary artery disease [1]. The authors discuss the anatomy and pathophysiology of LM disease, the technical considerations for LM percutaneous coronary intervention (PCI), and the latest research and most influential studies of PCI versus coronary artery bypass grafting (CABG) in LM disease. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 17, 2018 Category: Cardiology Authors: Edward T. Carreras, Deepak L. Bhatt Source Type: research
Editorial commentary: Beta blockers and the inertia of evidence-based medicine
One of the key limitations of evidence-based medicine is that most evidence becomes outdated. Secular changes in the epidemiology, diagnosis, and treatment of disease invariably erode the continued relevance of even the most well-conducted trials. As newer therapies are gradually stacked on the backs of older ones, the latter ’s effect sizes should tend to diminish or even disappear. Truly evidence-based medicine therefore requires a continuous reassessment of past successes, ideally through new randomized clinical trials in contemporary cohorts [1]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 16, 2018 Category: Cardiology Authors: Tristan D. Petrie, Joshua Schulman-Marcus Source Type: research
Beta blockers and the inertia of evidence-based medicine
One of the key limitations of evidence-based medicine is that most evidence becomes outdated. Secular changes in the epidemiology, diagnosis, and treatment of disease invariably erode the continued relevance of even the most well conducted trials. As newer therapies are gradually stacked on the backs of older ones, the latter's effect sizes should tend to diminish or even disappear. Truly evidence-based medicine therefore requires a continuous reassessment of past successes, ideally through new randomized clinical trials in contemporary cohorts [1]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 16, 2018 Category: Cardiology Authors: Tristan Petrie, Joshua Schulman-Marcus Source Type: research
Cardiac imaging in Ebstein anomaly
Ebstein anomaly is a congenital disorder of right ventricular myocardial development, which affects the tricuspid valve in addition to the right ventricular myocardium. Cardiac imaging by transthoracic echocardiography and cardiac magnetic resonance imaging are the key modalities used to assess timing and type of surgery. In this article, we review the current standards of echocardiographic and magnetic resonance imaging in Ebstein anomaly. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 12, 2018 Category: Cardiology Authors: Muhammad Yasir Qureshi, Patrick W. O ’Leary, Heidi M. Connolly Source Type: research
Cardiac imaging in ebstein anomaly
Ebstein anomaly is a congenital disorder of right ventricular myocardial development, which affects the tricuspid valve in addition to the right ventricular myocardium. Cardiac imaging by transthoracic echocardiography and cardiac magnetic resonance imaging are the key modalities used to assess timing and type of surgery. In this manuscript, we review the current standards of echocardiographic and magnetic resonance imaging in Ebstein anomaly. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 12, 2018 Category: Cardiology Authors: Muhammad Yasir Qureshi, Patrick W. O ’Leary, Heidi M. Connolly Source Type: research
Heart failure with preserved ejection fraction: Classification based upon phenotype is essential for diagnosis and treatment
Heart failure (HF) is classified based upon the left ventricular ejection fraction (LVEF). Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disorder with increasing prevalence in the elderly that remains incompletely understood and inadequately treated as no therapy has shown favorable effects. In this review, we summarize the current theories regarding HFpEF pathogenesis, propose a phenotype-based classification of HFpEF, discuss prevention strategies, explain why clinical trials on HFpEF treatment have failed, and make suggestions for the future. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 9, 2018 Category: Cardiology Authors: Andrew Xanthopoulos, Filippos Triposkiadis, Randall C. Starling Source Type: research
Heart Failure With Preserved Ejection Fraction: Classification Based Upon Phenotype is Essential For Diagnosis and Treatment
Heart failure (HF) is classified based upon the left ventricular ejection fraction (LVEF). Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disorder with increasing prevalence in the elderly that remains incompletely understood and inadequately treated as no therapy has shown favorable effects. In this review, we summarize the current theories regarding HFpEF pathogenesis, propose a phenotype based classification of HFpEF, discuss prevention strategies, explain why clinical trials on HFpEF treatment have failed, and make suggestions for the future. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 9, 2018 Category: Cardiology Authors: Andrew Xanthopoulos, Filippos Triposkiadis, Randall C. Starling Source Type: research
Editorial Board
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 7, 2018 Category: Cardiology Source Type: research
Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 7, 2018 Category: Cardiology Source Type: research
