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Medication safety in neonatal care: a review of medication errors among neonates
Conclusion: This review highlights that each step of the medication-use process is prone to error across the age spectrum. Further research is required to develop targeted strategies relevant to specific patient groups that integrate key pharmacy services into wards. (Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - June 1, 2016 Category: Drugs & Pharmacology Authors: Krzyzaniak, N., Bajorek, B. Tags: Original Research Source Type: research

Revisiting the reported signal of acute pancreatitis with rasburicase: an object lesson in pharmacovigilance
Discussion: Our exercise stimulated interesting discussions of key points in signal detection and evaluation, including causality assessment, signal detection algorithm performance, pharmacovigilance terminology, duplicate reporting, mechanisms for communicating signals, the structure of the FAERs database, and recent results from a major international pharmacovigilance research initiative. (Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - June 1, 2016 Category: Drugs & Pharmacology Authors: Hauben, M., Hung, E. Y. Tags: Original Research Source Type: research

Safety of high-dose doripenem in adult patients with cystic fibrosis
Conclusions: In adult patients with CF, HDD in combination with other antibiotics did not lead to adverse effects necessitating discontinuation. HDD should be considered in this selected patient population, particularly when high MIC organisms are identified. (Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - June 1, 2016 Category: Drugs & Pharmacology Authors: Strawbridge, S., Nailor, M. D. Tags: Original Research Source Type: research

Factors associated with antidepressant use in residents with and without dementia in Australian aged care facilities
Conclusions: The prevalence of antidepressant use was similar in residents with and without dementia. Clinician-observed pain was inversely associated with antidepressant use but there was no association between self-reported pain and antidepressant use. (Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - June 1, 2016 Category: Drugs & Pharmacology Authors: Hiltunen, H., Tan, E. C. K., Ilomäki, J., Hilmer, S. N., Visvanathan, R., Emery, T., Robson, L., Jones, M. J., Hartikainen, S., Bell, J. S. Tags: Original Research Source Type: research

Propofol-associated QTc prolongation
Conclusion: This historical cohort analysis of adult ICU patients receiving propofol suggests that on-infusion QTc prolongation was associated with increasing baseline QTc interval and with amiodarone use. Further research is needed to evaluate the clinical significance and cause-and-effect relationship between potential QTc changes and propofol use in the ICU. (Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - June 1, 2016 Category: Drugs & Pharmacology Authors: Scalese, M. J., Herring, H. R., Rathbun, R. C., Skrepnek, G. H., Ripley, T. L. Tags: Original Research Source Type: research

Use of doripenem and risk of seizure and renal impairment in US hospitalized patients: a retrospective cohort study
Conclusions: In this large retrospective cohort study of US hospitalized patients, no statistically significant differences in the adjusted relative rates of renal impairment/failure and seizure were observed between doripenem and a propensity score-matched comparator cohort of imipenem IV patients in the treatment of cUTI and cIAI. (Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - March 7, 2016 Category: Drugs & Pharmacology Authors: Chavers, S., Magee, G., Baumer, D., Pai, H. Tags: Original Research Source Type: research

Drug-induced falls in older persons: is there a role for therapeutic drug monitoring?
Conclusion/discussion: Older adults are more prone to the side effects of drug use, including falls. Therapeutic drug monitoring may be useful to identify the patients who have an increased drug-related fall risk and to prevent future falls by individualizing the drug regime. (Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - March 7, 2016 Category: Drugs & Pharmacology Authors: Hartholt, K. A., Becker, M. L., van der Cammen, T. J. M. Tags: Original Research Source Type: research

Cardiovascular risk with DPP-4 inhibitors: latest evidence and clinical implications
(Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - March 7, 2016 Category: Drugs & Pharmacology Authors: Karagiannis, T., Bekiari, E., Boura, P., Tsapas, A. Tags: Editorial Source Type: research

Risk of intracranial hypertension with intrauterine levonorgestrel: reply
(Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - January 15, 2016 Category: Drugs & Pharmacology Authors: Etminan, M. Tags: Letters to the Editor Source Type: research

Risk of intracranial hypertension with intrauterine levonorgestrel
(Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - January 15, 2016 Category: Drugs & Pharmacology Authors: Friedman, D. Tags: Letters to the Editor Source Type: research

Predicting risk of adverse drug reactions in older adults
Adverse drug reactions (ADRs) are common in older adults, with falls, orthostatic hypotension, delirium, renal failure, gastrointestinal and intracranial bleeding being amongst the most common clinical manifestations. ADR risk increases with age-related changes in pharmacokinetics and pharmacodynamics, increasing burden of comorbidity, polypharmacy, inappropriate prescribing and suboptimal monitoring of drugs. ADRs are a preventable cause of harm to patients and an unnecessary waste of healthcare resources. Several ADR risk tools exist but none has sufficient predictive value for clinical practice. Good clinical practice f...
Source: Therapeutic Advances in Drug Safety - January 15, 2016 Category: Drugs & Pharmacology Authors: Lavan, A. H., Gallagher, P. Tags: Review Source Type: research

Spontaneously reported haemorrhagic adverse events associated with rivaroxaban and dabigatran in Australia
Conclusions: Our study highlights the need for research on the haemorrhagic complications of anticoagulation in clinical care. A considerable proportion of reported haemorrhagic events occurred within 30 days of rivaroxaban and dabigatran initiation. This highlights the importance of considering bleeding risk at the time of treatment initiation. (Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - January 15, 2016 Category: Drugs & Pharmacology Authors: Chen, E. Y. H., Diug, B., Bell, J. S., Mc Namara, K. P., Dooley, M. J., Kirkpatrick, C. M., McNeil, J. J., Caughey, G. E., Ilomäki, J. Tags: Original Research Source Type: research

Dexmedetomidine-associated fever in the intensive care unit
(Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - November 27, 2015 Category: Drugs & Pharmacology Authors: Faust, A. C., Sutton, S. E. Tags: Letter to the editor Source Type: research

Routine deprescribing of chronic medications to combat polypharmacy
The positive benefit–risk ratio of most drugs is decreasing in correlation to very old age, the extent of comorbidity, dementia, frailty and limited life expectancy (VOCODFLEX). First, we review the extent of inappropriate medication use and polypharmacy (IMUP) globally and highlight its negative medical, nursing, social and economic consequences. Second, we expose the main clinical/practical and perceptual obstacles that combine to create the negative vicious circle that eventually makes us feel frustrated and hopeless in treating VOCODFLEX in general, and in our ‘war against IMUP’ in particular. Third, ...
Source: Therapeutic Advances in Drug Safety - November 27, 2015 Category: Drugs & Pharmacology Authors: Garfinkel, D., Ilhan, B., Bahat, G. Tags: Review Source Type: research

Safety and tolerability of 13-valent pneumococcal conjugate vaccine in healthy Chinese adults, children and infants
Conclusions: A single dose of PCV13 was safe and well tolerated in healthy Chinese adults, children, and infants. This study provided the safety data to enable a phase III safety and immunogenicity registration trial in Chinese infants to proceed. (Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - November 27, 2015 Category: Drugs & Pharmacology Authors: Zhu, F., Hu, Y., Liang, Q., Young, M., Zhou, X., Chen, Z., Liang, J. Z., Gruber, W. C., Scott, D. A. Tags: Original Research Source Type: research