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Safety of dipeptidyl peptidase 4 inhibitors: a perspective review
Dipeptidyl peptidase 4 (DPP-4) inhibitors are a relatively new class of oral antihyperglycemic agent that enhance insulin secretion by reducing degradation of endogenous glucagon-like peptide 1. Currently, sitagliptin, vildagliptin, saxagliptin, linagliptin and alogliptin have been approved by the US Food and Drug Administration or the European Medicines Agency for use in patients with type 2 diabetes. Their glycemic efficacy has been well documented; however, data regarding their long-term safety are as yet inconclusive. While preclinical studies have indicated a potential cardioprotective effect of DPP-4 inhibitors, curr...
Source: Therapeutic Advances in Drug Safety - May 8, 2014 Category: Drugs & Pharmacology Authors: Karagiannis, T., Boura, P., Tsapas, A. Tags: Reviews Source Type: research

Opioid formulations with sequestered naltrexone: a perspective review
In response to good-intentioned efforts to correct the traditional undertreatment of pain, opioid prescribing experienced a dramatic increase over the past decade. But there is now concern that the pendulum has swung too far in the opposite direction, with a rise in morbidity and mortality associated with prescription opioid misuse and abuse. Yet despite potential problems, opioids are a mainstay for the treatment of pain and are an important component of a comprehensive pain management strategy. Therefore, the overall goal of pain management is to decrease pain and to improve patient functioning and quality of life, while...
Source: Therapeutic Advances in Drug Safety - May 8, 2014 Category: Drugs & Pharmacology Authors: Taylor, R., Raffa, R. B., Pergolizzi, J. V. Tags: Reviews Source Type: research

Minimizing anticholinergic drug prescribing in older hospitalized patients: a full audit cycle
Conclusion: Consultant-led medication review (standard practice) was effective at reducing anticholinergic drug exposure in the acute setting. A system of alerting clinicians to patients prescribed anticholinergic medications further reduced anticholinergic drug exposure. (Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - May 8, 2014 Category: Drugs & Pharmacology Authors: Tay, H. S., Soiza, R. L., Mangoni, A. A. Tags: Original Research Source Type: research

Questioning the accuracy of trough concentrations as surrogates for area under the curve in determining vancomycin safety
(Source: Therapeutic Advances in Drug Safety)
Source: Therapeutic Advances in Drug Safety - May 8, 2014 Category: Drugs & Pharmacology Authors: Phillips, C. J. Tags: Editorial Source Type: research