The Journal of Steroid Biochemistry and Molecular Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data
In conclusion, this study shows, for the first time, that circulating levels of oxysterols, especially cholestane-3β,5α,6β-triol, may have prognostic roles in patients with luminal subtype breast cancer. (Source: The Journal of Steroid Biochemistry and Molecular Biology)
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 24, 2019 Category: Biochemistry Source Type: research

Bacterial steroid-17,20-desmolase is a taxonomically rare enzymatic pathway that converts prednisone to 1,4-androstanediene-3,11,17-trione, a metabolite that causes proliferation of prostate cancer cells
Publication date: Available online 20 December 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Lindsey K. Ly, Joe L. Rowles, Hans Müller Paul, João M.P. Alves, Camdon Yemm, Patricia M. Wolf, Saravanan Devendran, Matthew E. Hudson, David J. Morris, John W. Erdman, Jason M. RidlonAbstractThe adrenal gland has traditionally been viewed as a source of “weak androgens”; however, emerging evidence indicates 11-oxy-androgens of adrenal origin are metabolized in peripheral tissues to potent androgens. Also emerging is the role of gut bacteria in the conversion of C21 glucocorticoids to 11-oxyg...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 21, 2019 Category: Biochemistry Source Type: research

Vitamin D Receptor Fokl polymorphism is a determinant of both maternal and neonatal Vitamin D concentrations at birth
Publication date: Available online 20 December 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Spyridon N. Karras, Theocharis Koufakis, Vasiliki Antonopoulou, Dimitrios G. Goulis, Merve Alaylıoğlu, Erdinc Dursun, Diugy Gezen-Ak, Cedric Annweiler, Stefan Pilz, Hana Fakhoury, Fatme Al Anouti, Vikentia Harizopoulou, Declan P. Naughton, Pantelis Zebekakis, Kalliopi KotsaAbstractMaternal vitamin D deficiency is considered to be the key determinant of the development of neonatal vitamin D deficiency at birth and during early infancy. Specific vitamin D receptor (VDR) gene polymorphisms have been...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 21, 2019 Category: Biochemistry Source Type: research

Vitamin D deficiency in Kazakhstan: cross-sectional study
This study objected to evaluate Vitamin D status in adult population of both sexes residing in different geographical areas of Kazakhstan and to elucidate the possible contributing factors related to VDD.This cross-sectional study covered 6 regions of Kazakhstan and applied the systematic random sampling to recruit 1,347 healthy adults (of whom 819 were females) with mean age 44 ± 14 years. The concentration of 25-hydroxy vitamin D (25-OHD) was measured from May 2018 to August 2018 with Architect 25OH Vitamin D assay (Abbott Ireland Diagnostics Division Lisnamuck, Longford Co. Longford Ireland). Vitamin D deficiency w...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 6, 2019 Category: Biochemistry Source Type: research

Differential Quantitative Proteomics Reveals Key Proteins Related to Phenotypic Changes of Breast Cancer Cells Expressing Progesterone Receptor A
Publication date: Available online 3 December 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Prangwan Pateetin, Trairak Pisitkun, Eileen McGowan, Viroj BoonyaratanakornkitAbstractProgesterone receptor isoforms A and B exert different biological effects in breast cancer cells. Alteration of PRA/PRB ratio is often observed during breast cancer progression. High PRA/PRB ratios in breast cancer patients are associated with resistance to chemotherapy and poor prognosis. While it is well accepted that PRA and PRB regulate different sets of genes, how the expression of PRA and PRB alters breast ca...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 4, 2019 Category: Biochemistry Source Type: research

Obesity and Leptin Influence Vitamin D Metabolism and Action in Human Marrow Stromal Cells
In this study, we tested the hypotheses that 1) obesity has an influence on the ex vivo constitutive expression of vitamin D-hydroxylase genes in hMSCs, and 2) recombinant human (rh) Leptin regulates the D-hydroxylases and promotes osteoblastogenesis in hMSCs. In a cohort of female subjects undergoing joint replacement surgery, the effects of Body Mass Index (BMI) and Fat Mass Index (FMI) on BMD T-scores and s25(OH)D were evaluated. hMSCs were isolated from bone tissues discarded during surgery. The direct effects of rh-Leptin on osteoblast differentiation and D-related genes in hMSCs were examined in vitro. There were pos...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 4, 2019 Category: Biochemistry Source Type: research

ANTI-proliferative transcriptional effects of medroxyprogesterone acetate in Estrogen receptor positive breast cancer cells are predominantly mediated by ThE progesterone receptor
This study is the first to assess the relative contribution of progesterone, androgen and glucocorticoid receptors in mediating the transcriptional activity of MPA on endogenous targets in breast cancer cells that endogenously express all three receptors at comparable levels. Gene expression profiling in estrogen receptor positive (ER+) ZR-75-1 breast cancer cells demonstrated that although the MPA-regulated transcriptome strongly overlapped with that of Progesterone (PROG), 5α-dihydrotestosterone (DHT) and Dexamethasone (DEX), it clustered most strongly with that of PROG, suggesting that MPA predominantly acts via the pr...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 3, 2019 Category: Biochemistry Source Type: research

Clinical and hormonal characteristics in heterozygote carriers of congenital adrenal hyperplasia
Publication date: Available online 2 December 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Valentina Guarnotta, Marcello Niceta, Marianna Bono, Serena Marchese, Carmelo Fabiano, Serena Indelicato, Francesca Di Gaudio, Piernicola Garofalo, Carla GiordanoAbstractNon-classical congenital adrenal hyperplasia (NC-CAH) includes a group of genetic disorders due to a broad class of CYP21A2 variants identifying a disease-causing ‘C’ genotype.The heterozygous carriers of CYP21 mutations are at increased risk of developing clinically evident hyperandrogenism, even though clinical and laboratory ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 3, 2019 Category: Biochemistry Source Type: research

THE VITAMIN D ASSESSMENT (ViDA) STUDY – DESIGN AND MAIN FINDINGS
Publication date: Available online 3 December 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Robert ScraggAbstractAccumulating evidence from observational studies indicates that vitamin D status is inversely associated with a many non-skeletal diseases. This has initiated the conduct of several large clinical trials to determine if high dose vitamin D supplementation (≥ 2000 IU/day or monthly equivalent) prevents non-skeletal disease including cardiovascular disease, cancer and mortality. One of these trials is the Vitamin D Assessment (ViDA) Study which recruited 5,110 participants, aged...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 3, 2019 Category: Biochemistry Source Type: research

The Effects of Correction of Vitamin D Deficiency on Arterial stiffness: A Systematic Review and Updated Meta-analysis of Randomized Controlled Trials
Publication date: Available online 3 December 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Nai-Ching Chen, Chih-Yang Hsu, Pili Chi-Ming Mao, Gavin Dreyer, Fu-Zong Wu, Chien-Liang ChenAbstractIt is unclear whether nutritional vitamin D supplementation in vitamin D-deficient persons improves arterial stiffness. To conduct a meta-analysis of the effects of the nutritional vitamin D therapy on arterial stiffness in adults with vitamin D deficiency, the Scopus, PUBMED, EMBASE, and Cochrane databases were searched for systematic reviews conducted up to October 5, 2018. Randomized clinical trial...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 3, 2019 Category: Biochemistry Source Type: research

Nutritional rickets: Historic overview and plan for worldwide eradication
Publication date: Available online 3 December 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Roger Bouillon, Leen AntonioAbstractRickets was first described in great detail in the mid 17th century and was affecting a great number of children in major European cities. The disease, however, existed already in the Roman times. The etiology of this disease remained enigmatic until the 1920s when two different mechanisms, lack of exposure to sunlight and lack of a dietary factor were finally solved by the discovery of vitamin D and its dual origin. Soon thereafter, the implementation of vitamin ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 3, 2019 Category: Biochemistry Source Type: research

Characterizing neonatal vitamin D deficiency in the modern era: a maternal-neonatal birth cohort from Southern Europe
In conclusion, neonatal vitamin D deficiency is associated with maternal 25(OH)D concentrations at birth and maternal alcohol use. Further studies are required to replicate these findings in other regions and populations. (Source: The Journal of Steroid Biochemistry and Molecular Biology)
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 27, 2019 Category: Biochemistry Source Type: research

A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression
Publication date: Available online 26 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Malcolm B. Lowry, Chunxiao Guo, Yang Zhang, Mary L. Fantacone, Isabelle E. Logan, Yan Campbell, Weijian Zhang, Mai Le, Arup K. Indra, Gitali Ganguli-Indra, Jingwei Xie, Richard L. Gallo, H. Phillip Koeffler, Adrian F. GombartAbstractIn humans and other primates, 1,25(OH)2vitamin D3 regulates the expression of the cathelicidin antimicrobial peptide (CAMP) gene via toll-like receptor (TLR) signaling that activates the vitamin D pathway. Mice and other mammals lack the vitamin D response element (VDRE...
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 27, 2019 Category: Biochemistry Source Type: research

Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine
Publication date: Available online 26 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Deolinda Santinha, Anna Klopot, Igor Marques, Ewa Ellis, Carl Jorns, Helene Johansson, Tânia Melo, Per Antonson, Tomas Jakobsson, Vítor Félix, Jan-Åke Gustafsson, Maria Rosário Domingues, Agneta Mode, Luisa A. HelgueroAbstractLiver X receptor (LXR) agonists have the potential to alleviate obesity related diseases, particularly atherosclerosis. However, LXRs are transcriptional regulators that induce de novo lipogenesis and lipid accumulation in hepatocytes which represents a serious adverse ef...
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 27, 2019 Category: Biochemistry Source Type: research

Meta-Analysis of steroid-converting enzymes and related receptors in prostate cancer suggesting novel combined therapies
Publication date: Available online 26 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Wen-Fa Zhang, Tang Li, Sheng-Xiang LinAbstractAndrogen receptor (AR) signaling is essential for prostate cancer (PC) progression and treatment. Experiments have demonstrated that the intratumoral androgen levels are not affected by circulating androgen levels, but rather modulated by local steroid-converting enzyme activities. The expression modulation status of human steroid-converting enzymes and nuclear receptors are of great promise to identify novel therapeutic targets. Meta-analysis was perfo...
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 27, 2019 Category: Biochemistry Source Type: research