The Effects of Correction of Vitamin D Deficiency on Arterial stiffness: A Systematic Review and Updated Meta-analysis of Randomized Controlled Trials

Publication date: Available online 3 December 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Nai-Ching Chen, Chih-Yang Hsu, Pili Chi-Ming Mao, Gavin Dreyer, Fu-Zong Wu, Chien-Liang ChenAbstractIt is unclear whether nutritional vitamin D supplementation in vitamin D-deficient persons improves arterial stiffness. To conduct a meta-analysis of the effects of the nutritional vitamin D therapy on arterial stiffness in adults with vitamin D deficiency, the Scopus, PUBMED, EMBASE, and Cochrane databases were searched for systematic reviews conducted up to October 5, 2018. Randomized clinical trials that compared nutritional vitamin D therapy with placebo in adults with vitamin D deficiency were eligible. Two reviewers independently evaluated eligibility of all retrieved studies based on titles and abstracts. Meta-analysis was performed using random effect or fixed effects model and inverse variance method was used to calculate the effect using standardized mean difference (SMD) and weighted mean difference. A leave-one-out method was used for sensitivity analysis. The main outcome was arterial stiffness, indicated by the carotid-femoral pulse wave velocity (PWV). We identified 237 records, of which 9 satisfied the inclusion criteria of the study. Our meta-analysis included relatively high-quality placebo-controlled randomized trials. In a random-effects model, nutritional vitamin D was associated with significant reductions in the pooled difference o...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research