The Journal of Steroid Biochemistry and Molecular Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

1α, 25 Dihydroxyvitamin D (1,25(OH)2D) Inhibits the T cell Suppressive Function of Myeloid Derived Suppressor Cells (MDSC)
Publication date: Available online 26 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): J.C. Fleet, G.N. Burcham, R.D. Calvert, B.D. Elzey, T.L. RatliffAbstractMyeloid derived suppressor cells (MDSC) suppress the ability of cytotoxic T cells to attack and clear tumor cells from the body. The active form of vitamin D, 1,25 dihydroxyvitamin D (1,25(OH)2D), regulates myeloid cell biology and previous research showed that in mouse models 1,25(OH)2D reduced the tumor level of CD34+ cells, an MDSC precursor, and reduced metastasis. We tested whether MDSC are vitamin D target cells by examin...
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 27, 2019 Category: Biochemistry Source Type: research

Vitamin D and the nutritional environment in functions of intestinal stem cells: implications for tumorigenesis and prevention
Publication date: Available online 26 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Wenge Li, Karina Peregrina, Michele Houston, Leonard H. AugenlichtAbstractSporadic colon cancer accounts for ∼80% of CRC, with high incidence in western societies strongly linked to dietary patterns. The only mouse model for sporadic CRC results from feeding mice a purified rodent western-style diet (NWD1), establishing mouse intake of several common nutrients that mimic for each its level consumed in western populations at higher risk for colon cancer (higher fat, lower vitamin D3, calcium, meth...
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 27, 2019 Category: Biochemistry Source Type: research

SerpinB1 promotes the proliferation of porcine pancreatic stem cells through the STAT3 signaling pathway
In conclusion, this study demonstrates that SerpinB1 promotes the proliferation of pPSCs through the STAT3 signaling pathway, and SerpinB1 is a key factor for maintaining the viability of pPSCs during the transition to insulin-secreting cells. (Source: The Journal of Steroid Biochemistry and Molecular Biology)
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 27, 2019 Category: Biochemistry Source Type: research

17β-hydroxysteroid dehydrogenase type 12a responsible for testicular 11-ketotestosterone synthesis in the Japanese eel, Anguilla japonica
Publication date: Available online 25 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Hiroshi Suzuki, Yuichi Ozaki, Shigeho Ijiri, Koichiro Gen, Yukinori KazetoABSTRACTThe production of 11-ketotestosterone (11KT), an important steroid hormone in piscine spermatogenesis, is regulated by the pituitary gonadotropins [Gths: follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh)] and it is synthesized by catalytic reactions involving several steroidogenic enzymes. Among these enzymes, the role of 17β-hydroxysteroid dehydrogenases (Hsd17bs) that exhibited 17-ketosteroid reducing...
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 26, 2019 Category: Biochemistry Source Type: research

Urinary Steroidomic Profiles by LC-MS/MS to monitor Classic 21-Hydroxylase Deficiency
Publication date: Available online 26 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Eric Pussard, Simon Travers, Claire Bouvattier, Qiong-Yao Xue, Claudine Cosson, Say Viengchareun, Laetitia Martinerie, Marc LombèsABSTRACT21-hydroxylase deficiency, the most common enzyme defect associated with congenital adrenal hyperplasia (CAH) is characterized by an impairment of both aldosterone and cortisol biosynthesis. Close clinical and biological monitoring of Hydrocortisone (HC) and 9α-Fludrocortisone (FDR) replacement therapies is required to achieve an optimal treatment. As frequent ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 26, 2019 Category: Biochemistry Source Type: research