What we have learned about the design of randomized trials in pregnancy
For nearly 30 years the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal –Fetal Medicine Units (MFMU) Network has been conducting randomized trials in pregnant women, many of which have changed clinical practice. Since 1986, the MFMU Network has conducted 29 randomized trials, of which the 17 trials started or completed since 2003 are described here. Study design choic es are described including decisions regarding the fundamental questions to be answered and the rationale behind choices of primary and secondary outcomes. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - June 21, 2016 Category: Perinatology & Neonatology Authors: Elizabeth A. Thom, Madeline Murguia Rice, George R. Saade, Uma M. Reddy, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal –Fetal Medicine Units Network Source Type: research
Introduction
William E. Truog, MD (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - June 21, 2016 Category: Perinatology & Neonatology Authors: William E. Truog, Rosemary D. Higgins Source Type: research
Methodological issues in the design and analyses of neonatal research studies: Experience of the NICHD Neonatal Research Network
Impressive advances in neonatology have occurred over the 30 years of life of The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN). However, substantial room for improvement remains in investigating and further developing the evidence base for improving outcomes among the extremely premature. We discuss some of the specific methodological challenges in the statistical design and analysis of randomized trials and observational studies in this population. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - June 21, 2016 Category: Perinatology & Neonatology Authors: Abhik Das, Jon Tyson, Claudia Pedroza, Barbara Schmidt, Marie Gantz, Dennis Wallace, William E. Truog, Rosemary D. Higgins Source Type: research
What we have learned about the design of randomized trials in pregnancy
For nearly 30 years the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal–Fetal Medicine Units (MFMU) Network has been conducting randomized trials in pregnant women, many of which have changed clinical practice. Since 1986, the MFMU Network has conducted 29 randomized trials, of which the 17 trials started or completed since 2003 are described here. Study design choices are described including decisions regarding the fundamental questions to be answered and the rationale behind choices of primary and secondary outcomes. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - June 21, 2016 Category: Perinatology & Neonatology Authors: Elizabeth A. Thom, Madeline Murguia Rice, George R. Saade, Uma M. Reddy, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network Source Type: research
Introduction
William E. Truog, MD (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - June 21, 2016 Category: Perinatology & Neonatology Authors: William E. Truog, Rosemary D. Higgins Source Type: research
Methodological issues in the design and analyses of neonatal research studies: Experience of the NICHD Neonatal Research Network
Impressive advances in neonatology have occurred over the 30 years of life of The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN). However, substantial room for improvement remains in investigating and further developing the evidence base for improving outcomes among the extremely premature. We discuss some of the specific methodological challenges in the statistical design and analysis of randomized trials and observational studies in this population. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - June 21, 2016 Category: Perinatology & Neonatology Authors: Abhik Das, Jon Tyson, Claudia Pedroza, Barbara Schmidt, Marie Gantz, Dennis Wallace, William E. Truog, Rosemary D. Higgins Source Type: research
What we have learned about scheduling elective repeat cesarean delivery at term
The optimal timing of delivery in the setting of various clinical conditions and scenarios remains one of the most common questions for obstetric providers. Over the past 5 –10 years, the optimal timing of delivery at term, particularly for elective repeat cesareans, has been the subject of considerable investigation and discussion. There is an increasing consensus that when women opt for an elective repeat cesarean delivery, it should be performed at term rather tha n preterm. The recent redefinition of the “term” period into early term (37–38 weeks), full-term (39–40 weeks), late term (41 weeks), and post term ...
Source: Seminars in Perinatology - June 9, 2016 Category: Perinatology & Neonatology Authors: Alan T.N. Tita, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal –Fetal Medicine Units Network Source Type: research
What we have learned about scheduling elective repeat cesarean delivery at term
The optimal timing of delivery in the setting of various clinical conditions and scenarios remains one of the most common questions for obstetric providers. Over the past 5–10 years, the optimal timing of delivery at term, particularly for elective repeat cesareans, has been the subject of considerable investigation and discussion. There is an increasing consensus that when women opt for an elective repeat cesarean delivery, it should be performed at term rather than preterm. The recent redefinition of the “term” period into early term (37–38 weeks), full-term (39–40 weeks), late term (41 weeks), and post term de...
Source: Seminars in Perinatology - June 9, 2016 Category: Perinatology & Neonatology Authors: Alan T.N. Tita, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network Source Type: research
Cover
(Source: Seminars in Perinatology)
Source: Seminars in Perinatology - May 31, 2016 Category: Perinatology & Neonatology Source Type: research
Masthead
(Source: Seminars in Perinatology)
Source: Seminars in Perinatology - May 31, 2016 Category: Perinatology & Neonatology Source Type: research
Topics
(Source: Seminars in Perinatology)
Source: Seminars in Perinatology - May 31, 2016 Category: Perinatology & Neonatology Source Type: research
Table of Contents
(Source: Seminars in Perinatology)
Source: Seminars in Perinatology - May 31, 2016 Category: Perinatology & Neonatology Source Type: research
What We Have Learned About Trial of Labor After Cesarean Delivery from the Maternal-Fetal Medicine Units Cesarean Registry
The cesarean delivery rate in the United States has risen steadily over the past 5 decades such that approximately one in three women now undergo cesarean section. The rise in repeat operations and accompanying decline in trial of labor after cesarean (TOLAC) have been major contributors to this phenomenon. The appropriate use of TOLAC continues to be a topic of interest with the recognition that most women with a history of prior cesarean are candidates for trial of labor. The NICHD MFMU Network Cesarean Registry conducted from 1999 to 2002 provided contemporary data concerning the risks and benefits of TOLAC, which in tu...
Source: Seminars in Perinatology - May 18, 2016 Category: Perinatology & Neonatology Authors: Mark B. Landon, William A. Grobman, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal –Fetal Medicine Units Network Source Type: research
What we have learned about quality measures for intrapartum obstetrical care
This article reviews important concepts in the measurement of quality obstetrical care, and demonstrates how these concepts have been informed by the Assessment of Perinatal Excellence (APEX) study performed by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal –Fetal Medicine Units (MFMU) Network. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - May 18, 2016 Category: Perinatology & Neonatology Authors: Jennifer L. Bailit, William A. Grobman, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal –Fetal Medicine Units Network Source Type: research
What We Have Learned About Trial of Labor After Cesarean Delivery from the Maternal-Fetal Medicine Units Cesarean Registry
The cesarean delivery rate in the United States has risen steadily over the past 5 decades such that approximately one in three women now undergo cesarean section. The rise in repeat operations and accompanying decline in trial of labor after cesarean (TOLAC) have been major contributors to this phenomenon. The appropriate use of TOLAC continues to be a topic of interest with the recognition that most women with a history of prior cesarean are candidates for trial of labor. The NICHD MFMU Network Cesarean Registry conducted from 1999 to 2002 provided contemporary data concerning the risks and benefits of TOLAC, which in tu...
Source: Seminars in Perinatology - May 18, 2016 Category: Perinatology & Neonatology Authors: Mark B. Landon, William A. Grobman, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network Source Type: research
