Ultrasound screening: Status of markers and efficacy of screening for structural abnormalities
Aneuploidy is a major cause of perinatal morbidity and mortality and can have a significant impact on expecting parents and their families. With early screening and diagnosis it is important to be able to educate parents regarding the potential impact of the diagnosis. This knowledge allows parents the opportunity to consider management options early in the pregnancy, permitting more time to mentally and emotionally prepare both for the course of the pregnancy, and after the birth of the child should the pregnancy continue. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - January 8, 2016 Category: Perinatology & Neonatology Authors: Rashmi Rao, Lawrence D. Platt Source Type: research
Development of prenatal screening—A historical overview
The first prenatal screening test to be introduced was based on a single maternal serum marker of neural tube defects. Since then various prenatal screening concepts have been developed, the most successful being Down syndrome risk estimation using multiple serum and ultrasound markers. Today a completely new approach to aneuploidy screening is available based on maternal plasma cell-free DNA testing. This has the potential to markedly improve screening performance but routine testing is currently too expensive in a public health setting. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - January 4, 2016 Category: Perinatology & Neonatology Authors: Howard Cuckle, Ron Maymon Source Type: research
Obstetrical venous thromboembolism: Epidemiology and strategies for prophylaxis
Venous thromboembolism (VTE) is a leading cause of severe maternal morbidity and mortality. While pregnancy alone is a risk factor for VTE, additional population-based risk factors such as obesity are becoming increasingly common, particularly in the developed world. Maternal death from VTE is amenable to prevention and VTE thromboprophylaxis is the most readily implementable means of systematically reducing the maternal death rate. In the United States, prophylaxis is recommended primarily for patients at extremely high risk for thromboembolism and women undergoing cesarean delivery, whereas in the United Kingdom a larger...
Source: Seminars in Perinatology - December 29, 2015 Category: Perinatology & Neonatology Authors: Alexander Friedman, Cande Ananth Source Type: research
Venous thromboembolism bundle: Risk assessment and prophylaxis for obstetric patients
While venous thromboembolism (VTE) is a leading cause of severe maternal morbidity and mortality, maternal death from VTE is amenable to prevention. Thromboprophylaxis is the most readily implementable means of systematically reducing the maternal death rate, and protocols that identify at-risk women have led to a significant reduction in maternal deaths from VTE. Strategies to prevent VTE require minimal resources. A multidisciplinary working group convened as part of American Congress of Obstetricians and Gynecologists’ District II Safe Motherhood Initiative reviewed research evidence and major society thromboprophylax...
Source: Seminars in Perinatology - December 29, 2015 Category: Perinatology & Neonatology Authors: Alexander M. Friedman, Mary E. D’Alton Source Type: research
Obstetric hemorrhage: A global review
Postpartum hemorrhage remains the number one cause of maternal death globally despite the fact that it is largely a preventable and most often a treatable condition. While the global problem is appreciated, some may not realize that in the United States postpartum hemorrhage is a leading cause of mortality and unfortunately, the incidence is on the rise. In New York, obstetric hemorrhage is the second leading cause of maternal mortality in the state. National data suggests that hemorrhage is disproportionally overrepresented as a contributor to severe maternal morbidity and we suspect as we explore further this will be tru...
Source: Seminars in Perinatology - December 29, 2015 Category: Perinatology & Neonatology Authors: Dena Goffman, Lisa Nathan, Cynthia Chazotte Source Type: research
