Methodological issues in the design and analyses of neonatal research studies: Experience of the NICHD Neonatal Research Network

Impressive advances in neonatology have occurred over the 30 years of life of The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN). However, substantial room for improvement remains in investigating and further developing the evidence base for improving outcomes among the extremely premature. We discuss some of the specific methodological challenges in the statistical design and analysis of randomized trials and observational studies in this population.

Source: Seminars in Perinatology - June 21, 2016 Category: Perinatology & Neonatology Authors: Abhik Das, Jon Tyson, Claudia Pedroza, Barbara Schmidt, Marie Gantz, Dennis Wallace, William E. Truog, Rosemary D. Higgins Source Type: research