Juvenile Fibromyalgia: A Primary Pain, or Pain Processing, Disorder
Juvenile fibromyalgia, a chronic disorder of widespread musculoskeletal pain in combination with autonomic, sensory, and cognitive dysfunction, is responsible for considerable morbidity and impaired quality of life in affected patients and their families. Historically, fibromyalgia has been incorrectly characterized as a psychosomatic or psychogenic disorder, but new understanding of the science of pain has demonstrated unambiguously that it is an organic disorder of the pain processing system itself. (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - October 13, 2016 Category: Neurology Authors: Lawrence Zemel, Peter R. Blier, Lawrence Zemel, Peter Blier Source Type: research
Neuropathic and Myopathic Pain Seminars in Pediatric Neurology
The evaluation and management of childhood pain syndromes of neuromuscular origin present distinct challenges, as the patterns of disease presentation and the ability of a child to describe symptoms may differ from that of an adult. Advances in scientific and clinical knowledge are leading to significant progress in the care of affected children. The genetic origins of Fabry disease and the inherited form of erythromelalgia have become better understood. The increasing interest in neuroimmunology among pediatric neurologists has led to more sophisticated diagnostic and therapeutic approaches. (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - October 13, 2016 Category: Neurology Authors: Anthony C. Rodrigues, Peter B. Kang Source Type: research
In Memoriam: Sandra L. Helmers, MD, MPH (1957 –2016)
Sandy received her medical degree from the University of Cincinnati, completed internship at the Mary Imogene Bassett Hospital, Columbia University, residency at the Mayo Graduate School of Medicine, and clinical neurophysiology fellowship at the Massachusetts General Hospital, Harvard University. Her first academic position was at Children ׳s Hospital, Boston, where she joined the clinical neurophysiology laboratory and epilepsy program. Although Sandy did not train as a pediatric neurologist, this was not evident to her colleagues or patients. (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - June 21, 2016 Category: Neurology Authors: Gregory L. Holmes Source Type: research
In Memoriam: Sandra L. Helmers, MD, MPH (1957-2016)
Sandy received her medical degree from the University of Cincinnati, completed internship at the Mary Imogene Bassett Hospital, Columbia University, residency at the Mayo Graduate School of Medicine, and clinical neurophysiology fellowship at the Massachusetts General Hospital, Harvard University. Her first academic position was at Children ׳s Hospital, Boston, where she joined the clinical neurophysiology laboratory and epilepsy program. Although Sandy did not train as a pediatric neurologist, this was not evident to her colleagues or patients. (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - June 21, 2016 Category: Neurology Authors: Gregory L. Holmes Source Type: research
In Memoriam: Sandra L. Helmers, MD, MPH (1957-2016)
Sandy received her medical degree from the University of Cincinnati, completed internship at the Mary Imogene Bassett Hospital, Columbia University, residency at the Mayo Graduate School of Medicine, and clinical neurophysiology fellowship at the Massachusetts General Hospital, Harvard University. Her first academic position was at Children׳s Hospital, Boston, where she joined the clinical neurophysiology laboratory and epilepsy program. Although Sandy did not train as a pediatric neurologist, this was not evident to her colleagues or patients. (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - June 21, 2016 Category: Neurology Authors: Gregory L. Holmes Source Type: research
In Memoriam: Sandra L. Helmers, MD, MPH (1957–2016)
Image 1 (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - June 21, 2016 Category: Neurology Authors: Gregory L. Holmes Source Type: research
In Memoriam: John “Jack” Pellock, MD (1944−2016)
Jack received his medical degree from St. Louis University School of Medicine, in St. Louis, MO, in 1971. He completed housestaff training in pediatrics on Virginia Commonwealth University, Medical College of Virginia in 1973 and fellowship training in child neurology at Columbia Presbyterian Medical Center in 1976. He was on the Virginia Commonwealth University faculty since 1978 and served as chairman of the division of child neurology from 1995-2014. (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - June 20, 2016 Category: Neurology Authors: Gregory L. Holmes Source Type: research
In Memoriam: John “Jack” Pellock, MD (1944-2016)
Jack received his medical degree from St. Louis University School of Medicine, in St. Louis, MO, in 1971. He completed housestaff training in pediatrics on Virginia Commonwealth University, Medical College of Virginia in 1973 and fellowship training in child neurology at Columbia Presbyterian Medical Center in 1976. He was on the Virginia Commonwealth University faculty since 1978 and served as chairman of the division of child neurology from 1995-2014. (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - June 20, 2016 Category: Neurology Authors: Gregory L. Holmes Source Type: research
In Memoriam: John “Jack” Pellock, MD (1944–2016)
Image 1 (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - June 20, 2016 Category: Neurology Authors: Gregory L. Holmes Source Type: research
Introduction
Recent years have witnessed an explosion of knowledge about genetic causes of infantile epileptic encephalopathies. Many of these syndromes were previously considered symptomatic of unknown etiology or, simply, cryptogenic. These discoveries are providing insights into the underlying pathophysiology of these epileptic syndromes as well as novel opportunities for better diagnosis, prognostication, genetic counseling, and even precision therapies. With the ever accelerating pace of research and discovery in this field, there is, thus, an increasingly widening gap in the knowledge of clinicians of the full range of recent dis...
Source: Seminars in Pediatric Neurology - June 16, 2016 Category: Neurology Authors: Mohamad A. Mikati Source Type: research
Introduction
Recent years have witnessed an explosion of knowledge about genetic causes of infantile epileptic encephalopathies. Many of these syndromes were previously considered symptomatic of unknown etiology or, simply, cryptogenic. These discoveries are providing insights into the underlying pathophysiology of these epileptic syndromes as well as novel opportunities for better diagnosis, prognostication, genetic counseling and even precision therapies. With the ever accelerating pace of research and discovery in this field, there is, thus, an increasingly widening gap in the knowledge of clinicians of the full range of recent disc...
Source: Seminars in Pediatric Neurology - June 16, 2016 Category: Neurology Authors: Mohamad A. Mikati Source Type: research
Focal Cortical Dysplasia in Childhood Epilepsy
Malformations of cortical development (MCD) comprise a spectrum of brain abnormalities caused by defects in brain development, failing to elaborate a functional laminated cortex. Focal cortical dysplasias (FCD) are a subgroup of MCD characterized by aberrant cortical architecture in a localized area of the brain, and have been reported as the most frequent structural brain lesion encountered in children submitted to surgery for medication resistant epilepsy.1,2 Increasing efforts have been made in the last decade to better define the different types of FCD and understand their pathophysiology, hoping this could help identi...
Source: Seminars in Pediatric Neurology - June 13, 2016 Category: Neurology Authors: Tarek Shaker, Anne Bernier, Lionel Carmant Source Type: research
Amenable Treatable Severe Pediatric Epilepsies
Vitamin-dependent epilepsies and multiple metabolic epilepsies are amenable to treatment that markedly improves the disease course. Knowledge of these amenably treatable severe pediatric epilepsies allows for early identification, testing, and treatment. These disorders present with various phenotypes, including early onset epileptic encephalopathy (refractory neonatal seizures, early myoclonic encephalopathy, and early infantile epileptic encephalopathy), infantile spasms, or mixed generalized seizure types in infancy, childhood, or even adolescence and adulthood. (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - June 6, 2016 Category: Neurology Authors: Phillip L. Pearl Source Type: research
