Central sensitization associated with low fetal hemoglobin levels in adults with sickle cell anemia
Conclusions Exaggerated temporal summation responses provide evidence of central sensitization in SCA. Implications The association with fetal hemoglobin suggests this known SCA modifier may have a therapeutic role in modulating central sensitization. (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - October 1, 2017 Category: Anesthesiology Source Type: research
The relationship between chronic musculoskeletal pain, anxiety and mindfulness: Adjustments to the Fear-Avoidance Model of Chronic Pain
Conclusions The present study provides insight into the strength and direction of the relationships between ruminative anxiety, mindfulness and chronic pain in a CMP population, demonstrating the unique associations between specific mindfulness factors and chronic pain elements. Implications It is possible that ruminative anxiety and mindfulness should be added into the Fear-Avoidance Model of Chronic Pain, with ruminative anxiety as a psychological vulnerability and mindfulness as an effective treatment strategy that breaks the cycle of chronic pain. This updated Fear-Avoidance Model should be explored further to determi...
Source: Scandinavian Journal of Pain - September 30, 2017 Category: Anesthesiology Source Type: research
Finally a promising analgesic signal in a long-awaited new class of drugs: TRPV1 antagonist mavatrep in patients with osteoarthritis (OA)
Publication date: October 2017 Source:Scandinavian Journal of Pain, Volume 17 Author(s): Rolf Karlsten (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - September 29, 2017 Category: Anesthesiology Source Type: research
Do we need an updated definition of pain?
Publication date: Available online 22 September 2017 Source:Scandinavian Journal of Pain Author(s): Per Brodal (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - September 23, 2017 Category: Anesthesiology Source Type: research
Pregabalin as adjunct in a multimodal pain therapy after traumatic foot amputation – A case report of a 4-year-old girl
Conclusion The multimodal pain therapy including pregabalin was well tolerated, safe and highly effective in this case of traumatic limb injury and subsequent amputation. The use of pregabalin allowed significant pain and anxiety reduction for the patient. Implications Pregabalin is frequently used in adult patients for severe complex pain syndromes. There are only few reports of such adjunct medication (pregabalin) in paediatric pain syndromes. These reports focus mainly on the paediatric oncologic population. The case reported here encourages physicians to consider adjunct medications when treating complex pain, which a...
Source: Scandinavian Journal of Pain - September 23, 2017 Category: Anesthesiology Source Type: research
Opioids in chronic pain – Primum non nocere
Publication date: October 2017 Source:Scandinavian Journal of Pain, Volume 17 Author(s): Katri Hamunen (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - September 23, 2017 Category: Anesthesiology Source Type: research
Severe side effects from intrathecal morphine for chronic pain after repeated failed spinal operations
Publication date: October 2017 Source:Scandinavian Journal of Pain, Volume 17 Author(s): Bård Lundeland, Lars Janerås, Gunnvald Kvarstein (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - September 23, 2017 Category: Anesthesiology Source Type: research
Predictors of chronic neuropathic pain after scoliosis surgery in children
Conclusions The present study found a high proportion of paediatric patients developing chronic persistent pain after surgical correction of scoliosis diformity. It allows identifying two factors associated with the occurrence of persistent chronic pain with a neuropathic component: the presence of persistent preoperative pain during the 3 months preceeding surgery and postoperative opioid consumption at day 1 ≥0.5mgkg−1. Implication Patients scheduled for spine surgery and presenting with preoperative pain should be considered at risk of chronic pain after surgery and managed accordingly by the chronic and/or acute p...
Source: Scandinavian Journal of Pain - September 22, 2017 Category: Anesthesiology Source Type: research
The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injury
Conclusions We demonstrate the negative effects of an American diet on physiology, behavior and recovery from injury. SAD consumption elevated pro-inflammatory mediators and increased microglial activation in the spinal cord. While there were sex differences in weight gain and inflammation, both sexes showed prolonged recovery from injury. Implications These data suggest that poor quality diet may increase susceptibility to chronic pain due to persistent peripheral and central immune system activation. Furthermore, consumption of a diet that is high in carbohydrates and omega-6 polyunsaturated fatty acid is likely to lead...
Source: Scandinavian Journal of Pain - September 19, 2017 Category: Anesthesiology Source Type: research
Coping with pain in intimate situations: Applying the avoidance-endurance model to women with vulvovaginal pain
Conclusions This study indicates that the strategies women with vulvovaginal pain use for coping with sexual activities are important for the course of pain. Avoidance and, to a lesser degree, endurance strategies were identified as important mediators of the effects of catastrophizing on pain. When exploring the links over time, only avoidance emerged as a significant mediator. Implications In this longitudinal study, catastrophizing was linked to vulvovaginal pain, via avoidance and endurance of sexual activities. Hence, targeting catastrophizing early on in treatment, as well as addressing coping, may be important in c...
Source: Scandinavian Journal of Pain - September 19, 2017 Category: Anesthesiology Source Type: research
Atlas of Pain Management Injection Techniques, 4th edition, S. Waldman. Elsevier (2017)
Publication date: Available online 18 September 2017 Source:Scandinavian Journal of Pain Author(s): Harald Breivik (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - September 19, 2017 Category: Anesthesiology Source Type: research
Hyperbaric oxygenation alleviates chronic constriction injury (CCI)-induced neuropathic pain and inhibits GABAergic neuron apoptosis in the spinal cord
Conclusions CCI-induced neuropathic pain was associated with increased apoptotic GABAergic neurons induced by activation of key proteins of mitochondrial apoptotic pathways in the dorsal horn of the spinal cord. HBO alleviated CCI-induced neuropathic pain and reduced GABAergic neuron apoptosis. The beneficial effect of HBO may be via its inhibitory role in CCI-induced GABAergic neuron apoptosis by suppressing mitochondrial apoptotic pathways in the spinal cord. Implications Increased apoptotic GABAergic neurons induced by activation of key proteins of mitochondrial apoptotic pathways in the dorsal horn of the spinal cord ...
Source: Scandinavian Journal of Pain - September 15, 2017 Category: Anesthesiology Source Type: research
Advances in Anesthesia, Vol. 33. Elsevier (2015)
Publication date: Available online 13 September 2017 Source:Scandinavian Journal of Pain Author(s): Harald Breivik (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - September 14, 2017 Category: Anesthesiology Source Type: research
A glimpse into a neglected population – Emerging adults
Publication date: Available online 12 September 2017 Source:Scandinavian Journal of Pain Author(s): Stephen Butler (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - September 13, 2017 Category: Anesthesiology Source Type: research
Erector spinae plane (ESP) block in the management of post thoracotomy pain syndrome: A case series
Conclusion The results observed in this case series indicate that the ESP block may be a valuable therapeutic option in the management of PTPS. Its immediate analgesic efficacy provides patients with temporary symptomatic relief while other aspects of chronic pain management are optimized, and it may also often confer prolonged analgesia. Implications The relative simplicity and safety of the ESP block offer advantages over other interventional procedures for thoracic pain; there are few contraindications, the risk of serious complications (apart from local anesthetic systemic toxicity) is minimal, and it can be performed...
Source: Scandinavian Journal of Pain - September 12, 2017 Category: Anesthesiology Source Type: research
