The risk of pain syndrome affecting a previously non-painful limb following trauma or surgery in patients with a history of complex regional pain syndrome
Conclusions These result suggest that patients with a history of CRPS are more likely to develop secondary CRPS compared to the rates reported in the literature among the general population. Implications Patients with a history of CRPS should be counselled that they may be at risk for developing secondary CRPS if they undergo surgery or sustain trauma to another extremity. (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - November 22, 2016 Category: Anesthesiology Source Type: research
Multi-target treatment of bone cancer pain using synergistic combinations of pharmacological compounds in experimental animals
Publication date: January 2017 Source:Scandinavian Journal of Pain, Volume 14 Author(s): Antti Pertovaara (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - November 22, 2016 Category: Anesthesiology Source Type: research
Symptoms and signs possibly indicating segmental, discogenic pain. A fusion study with 18 years of follow-up
Conclusions The results may suggest that the use of a detailed symptom analysis and clinical examination may make it possible to select a subgroup of patients within the CLBP group likely to have better outcome following fusion surgery. Implications The next step would be to execute prospective studies and if our findings concerning back pain details and signs among CLPB patients can be confirmed this can provide for more accurate selection of patients suitable for fusion surgery. Graphical abstract (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - November 21, 2016 Category: Anesthesiology Source Type: research
Positive affect could reduce the impact of pain
Publication date: Available online 21 November 2016 Source:Scandinavian Journal of Pain Author(s): Silje Endresen Reme (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - November 21, 2016 Category: Anesthesiology Source Type: research
Physical and occupational therapy outcomes: Adolescents ’ change in functional abilities using objective measures and self-report
Conclusions The LEFS, UEFI, and objective exercises provide a meaningful way to track progress in pediatric chronic pain rehabilitation. Despite similarities, they appear to track separate but related aspects of rehabilitation and capture important short-term response to rehabilitation. Both measures appear distinct from pain as an outcome. These findings increase our understanding of rehabilitation practices provide opportunities to promote clinical improvement in pediatric pain. Implications The use of self-report measures along with objective measures can help therapists gain understanding in regards to a patient's ins...
Source: Scandinavian Journal of Pain - November 4, 2016 Category: Anesthesiology Source Type: research
Treatment response and central pain processing in Anterior Cutaneous Nerve Entrapment Syndrome: An explorative study
Conclusion and Implications In this hypothesis-generating exploratory study, ACNES patients refractory to treatment showed more signs of sensitized segmental and central pain processing. A longer duration of complaints before diagnosis and treatment may be related to these alterations in pain processing, and both findings could be associated with less effective locally orientated treatment. In order to validate these hypotheses further research is needed. Registration number NCT01920880 (Clinical Trials Register; http://www.clinicaltrials.gov). (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - November 3, 2016 Category: Anesthesiology Source Type: research
Treatment success in neck pain: The added predictive value of psychosocial variables in addition to clinical variables
Conclusions Based on the results of this study we conclude that outcome expectancy, in patients with non-specific sub-acute and chronic neck pain, has additional predictive value for treatment success above and beyond clinical and demographic variables. Implications Psychological processes, health perceptions and how these factors relate to clinical variables may be important for treatment decision making regarding therapeutic options for individual patients. (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - November 1, 2016 Category: Anesthesiology Source Type: research
Multimodal intrathecal analgesia in refractory cancer pain
Conclusion and implications Multimodal IT treatment with morphine, bupivacaine and clonidine is effective and safe for treating refractory cancer pain in the terminal phase of disease. The study offers an important contribution to literature where there is still lack of convincing evidence about the benefits and harms of this type of pain management in patients with otherwise refractory cancer pain. (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - November 1, 2016 Category: Anesthesiology Source Type: research
Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain
Conclusions These multi-target-based antinociceptive strategies using combinations of non-opioid drugs with dual inhibitors of enkephalin degrading enzymes may bring therapeutic advantages in terms of efficacy and safety by allowing the reduction of doses of one of the compounds or of both, which is of the utmost interest in the chronic treatment of cancer pain. Implications This article presents synergistic antinociceptive effect produced by the combination of PL265 with non-opioid analgesic drugs acting via unrelated mechanisms. These multi-target-based antinociceptive strategies may bring therapeutic advantages by allo...
Source: Scandinavian Journal of Pain - November 1, 2016 Category: Anesthesiology Source Type: research
Objective methods for the assessment of the spinal and supraspinal effects of opioids
Conclusion and Implications The presented methods can all be used as objective methods for assessing the centrally mediated effects of opioids. Advantages and limitations should be considered before implementation in drug development, future experimental studies as well as in clinical settings. In conclusion, pupillometry is a sensitive measurement of opioid receptor activation in the CNS and from a practical and economical perspective it may be used as a biomarker for opioid effects in the CNS. However, if more detailed information is needed on opioid effects at different levels of the CNS, then EEG, fMRI, PET and NWR hav...
Source: Scandinavian Journal of Pain - November 1, 2016 Category: Anesthesiology Source Type: research
Optimists fare better when chronic pain strikes – Or does pain related disability make us pessimists?
Publication date: October 2016 Source:Scandinavian Journal of Pain, Volume 13 Author(s): Christopher Sivert Nielsen (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - October 28, 2016 Category: Anesthesiology Source Type: research
Pain management in the Emergency Department – Still a long way to go?
Publication date: October 2016 Source:Scandinavian Journal of Pain, Volume 13 Author(s): Jan Persson (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - October 28, 2016 Category: Anesthesiology Source Type: research
Effect of expectation on pain assessment of lower- and higher-intensity stimuli
Conclusion The obtained results imply that expectation manipulation can achieve the desired effect of decreasing or increasing both slight and more severe pain for a longer period of time. Manipulation via expectation before the stimuli series was proven to be effective for pain modulation in the entire series of stimuli which lasted around 10min. The results suggest a potential benefit of manipulating expectations to alleviate emerging pain, since the obtained effects are moderate to large. Implications It seems that expectation effect is strong enough to “overcome” even the direct effect of stimulus intensity (at le...
Source: Scandinavian Journal of Pain - October 26, 2016 Category: Anesthesiology Source Type: research
Bringing the lab to the people: Experimental pain testing in the general population
Publication date: October 2016 Source:Scandinavian Journal of Pain, Volume 13 Author(s): Christopher Sivert Nielsen (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - October 14, 2016 Category: Anesthesiology Source Type: research
Chronic neck pain patients with traumatic or non-traumatic onset: Differences in characteristics. A cross-sectional study
Conclusions This study showed significant differences between chronic neck pain patients when differentiated into groups based on their onset of pain. However, no specific clinical test or self-reported characteristic could differentiate between the groups at an individual patient level. Implications Pressure pain threshold tests, cervical muscle performance tests and patient-reported characteristics about self-perceived function and psychological factors may assist in profiling chronic neck pain patients. The need for more intensive management of those with a traumatic onset compared with those with a non-traumatic onset...
Source: Scandinavian Journal of Pain - October 12, 2016 Category: Anesthesiology Source Type: research
