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Renal involvement in paroxysmal nocturnal haemoglobinuria: a brief review of the literature
CONCLUSION: There is a lack of information in literature regarding renal involvement in PNH, albeit it is possible to state that the pathophysiological mechanisms of acute and chronic impairment differ. Despite not being a curative therapy, Eculizumab is able to ease kidney lesions in these patients.RESUMO INTRODU ÇÃO: A hemoglobinúria paroxística noturna (HPN) é uma doença genética adquirida, caracterizada por hemólise mediada pelo sistema complemento, eventos trombóticos e citopenias variáveis. Envolvimento renal pode ocorrer, contribuindo com morbidade significativa nesses pacientes. OBJETIVO: R ealização ...
Source: Revista da Associacao Medica Brasileira - December 17, 2018 Category: General Medicine Source Type: research

Proprioceptive Stabilizer™ training of the abdominal wall muscles in healthy subjects: a quasi-experimental study
SUMMARY The present quasi-experimental study aimed to assess the transversus abdominis (TrA), internal oblique (IO) and external oblique (EO) thickness in healthy subjects with the proprioceptive Stabilizer ™ training in abdominal wall muscles. A sample of 41 healthy participants (age: 31.9 ± 4.5 y; height: 1.7 ± 0.1 m; weight: 68.3 ± 13.1 kg; body mass index, BMI: 22.9 ± 2.7 kg/m2) were recruited to participate in this study. Ultrasound images of the EO, IO, TrA, rectus anterior (RA) and interrecti distance (IRD) were measured and analyzed by the ImageJ software. Measurements were made at rest and during the abdom...
Source: Revista da Associacao Medica Brasileira - December 17, 2018 Category: General Medicine Source Type: research

Evaluation of estrogen receptor expression in low-grade and high-grade astrocytomas
CONCLUSION: In the current study, estrogen receptor expression was positive only in low-grade astrocytomas and nil in high-grade astrocytomas, showing that ER expression declines with the grade of tumor malignancy.RESUMO OBJETIVO: O objetivo deste estudo é comparar a expressão do receptor de estrogênio entre astrocitomas de baixo e alto grau. MÉTODO: Foi realizado um estudo usando blocos de parafina de tumores gliais dos arquivos de Anatomia Patológica do Hospital São Marcos e iniciado após aprovação pelo Comitê de Ética da Universidade Federal do Piauí. Os espécimes foram marcados histoquimicamente com anti...
Source: Revista da Associacao Medica Brasileira - December 17, 2018 Category: General Medicine Source Type: research

Adiponectin levels and sleep deprivation in patients with endocrine metabolic disorders
CONCLUSION: In patients with EMD, adiponectin is influenced not only by obesity but also by age and sleep deprivation. The latter finding may be explained by a compensatory effect or a counter regulation to minimize the harmful effects of sleep deprivation.RESUMO INTRODU ÇÃO: Problemas de sono são frequentes em pacientes com distúrbios endócrino-metabólicos (DEM), como hipertensão arterial, diabetes e obesidade. A adiponectina é um peptídeo segregado por adipócitos e apresenta diversas propriedades, como por exemplo, anti-inflamatória, antioxidante, antia terogênica, pró-angiogênica e vasoprotetora. A adipon...
Source: Revista da Associacao Medica Brasileira - December 17, 2018 Category: General Medicine Source Type: research

Evaluation of liquid or foam sclerotherapy in small varicose veins (ceap c1) with venous clinical severity score
CONCLUSION: In conclusion, we observed that both sclerotherapy methods are effective with a low rate of complications, alleviating the complaints of patients with small varicose veins, and providing considerable improvement in venous clinical severity scores.RESUMO OBJETIVO: Nosso objetivo foi avaliar a efic ácia de líquido ou espuma na escleroterapia de varizes por meio de escores de gravidade clínica venosa e possíveis complicações. MÉTODOS: Um total de 318 pacientes (268 do sexo feminino, 50 do sexo masculino) tratados com escleroterapia com espuma ou líquido entre janeiro de 2012 e dezembro de 2012 foi inclu...
Source: Revista da Associacao Medica Brasileira - December 17, 2018 Category: General Medicine Source Type: research