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Teaching transfusion medicine: current situation and proposals for proper medical training
The current curricula in medical schools and hospital residence worldwide lack exposure to blood transfusion medicine, and require the reformulation of academic programs. In many countries, training in blood transfusion is not currently offered to medical students or during residency. Clinical evidence indicates that blood transfusions occur more frequently than recommended, contributing to increased risk due to this procedure. Therefore, the rational use of blood and its components is essential, due to the frequent undesirable reactions, to the increasing demand of blood products and the cost of the process. Signiﬁcant ...
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

A case of chronic myeloid leukemia with the m-bcr (p190) molecular rearrangement identiﬁed during treatment
Conclusion: It is possible to standardize single nucleotide polymorphism array analysis in acute myeloid leukemia/myelodysplastic syndromes and compare the results with the abnormalities detected by karyotyping. Single nucleotide polymorphism array analysis increased the detection rate of abnormalities compared to karyotyping and also identiﬁed a new set of abnormalities that deserve further investigation in future studies. (Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Identifying the similarities and differences between single nucleotide polymorphism array (SNPa) analysis and karyotyping in acute myeloid leukemia and myelodysplastic syndromes
Conclusion: It is possible to standardize single nucleotide polymorphism array analysis in acute myeloid leukemia/myelodysplastic syndromes and compare the results with the abnormalities detected by karyotyping. Single nucleotide polymorphism array analysis increased the detection rate of abnormalities compared to karyotyping and also identiﬁed a new set of abnormalities that deserve further investigation in future studies. (Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Prevalence of anemia in a sample of elderly southeastern Brazilians
Conclusion: A total of 18.6% of elderly people from São José dos Campos had mild anemia with the majority being normocytic. The percentages of anemia rose as the age increased demonstrating an association between age and anemia. (Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Association between maternal and fetal factors and quality of cord blood as a source of stem cells
Conclusions: Delivery route and birth weight inﬂuence the volume of cord blood and the total nucleated cell count. Gestational age inﬂuences only the volume of cord blood. (Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Immunohistochemical evaluation of CD20 expression in patients with multiple myeloma
Conclusion: The combination of immunohistochemical studies with ﬂow cytometry may reveal the importance of CD20 positivity in patients with multiple myeloma more clearly. (Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Results of high-risk neutropenia therapy of hematology-oncology patients in a university hospital in Uruguay
Conclusion: The high rate of gram-negative bacilli resistant to piperacillin/tazobactam (frontline antibiotics in our protocol) and the early need to escalate to carbapenems raises the question as to whether it is necessary to change the current protocol. (Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Acute myeloid leukemia: survival analysisof patients at a university hospital of Paraná
Conclusion: Prognostic factors strongly inﬂuenced patient survival, as well as guided treat- ment. Moreover, these factors were consistent with the available literature adjusted for the population in question. (Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Diversity of breakpoints of variant Philadelphia chromosomes in chronic myeloid leukemia in Brazilian patients
Conclusion: Among all the breakpoints seen in this survey, six had previously been described: 11p15, 14q32, 15q11.2, 16p13.1, 17p13 and 17q21. The fact that some regions get more fre- quently involved in such rare rearrangements calls attention to possible predisposition that should be further studied. Nevertheless, the pathological implication of these variants remains unclear. (Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Trends in mortality and hospital admissions of sickle cell disease patients before and after the newborn screening program in Maranhão, Brazil
Conclusion: The increases in the rates of hospitalization and death after the implementation of neonatal screening suggests that previously there was an underdiagnosis of sickle cell disease and that screening, along with other factors, increased "visibility" in the state of Maranhão. (Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Trends in mortality of adult patients diagnosed with myeloid leukemia from 1994 to 2011 in southeastern Brazil
Conclusion: Our data suggest a signiﬁcant decline per year in age-adjusted mortality rates of adult patients diagnosed with myeloid leukemia from 1994 to 2011 in the Vale do Paraíba, State of São Paulo. (Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

The invisibility of sickle cell disease in Brazil: lessons from a study in Maranhao
(Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Myeloid leukemia: are we getting better?
(Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Many thanks to our eternal Editor of the Revista Brasileira de Hematologia e Hemoterapia, Professor Milton Artur Ruiz
(Source: Revista Brasileira de Hematologia e Hemoterapia)
Source: Revista Brasileira de Hematologia e Hemoterapia - March 2, 2015 Category: Hematology Source Type: research

Guidelines on the treatment of anemia of chronic renal failure using recombinant human erythropoietin: Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Guidelines Project: Associação Médica Brasileira – 2014
Poisons of caterpillars have different effects on inflammatory and coagulation systems. This is a case report of a 2-year-old child that accidentally came in contact with several caterpillars of the species Lonomia obliqua. At first, the patient's exams presented abnormal coagulation and decreased fibrinogen, but the patient did not evolve to active bleeding or acute renal failure. The patient received antilonomic serum 15 h after the accident and the treatment was repeated after another 12 h due to persistent alterations shown by the coagulation exams. The venom of L. obliqua has several substances that act on the coagula...
Source: Revista Brasileira de Hematologia e Hemoterapia - January 11, 2015 Category: Hematology Source Type: research