Development of oxaliplatin encapsulated in magnetic nanocarriers of pectin as a potential targeted drug delivery for cancer therapy
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Raj Kumar Dutta , Saurabh Sahu Superparamagnetic iron oxide nanoparticles (SPIONs) and oxaliplatin (OHP) were in-situ encapsulated in pectin cross-linked with Ca2+ forming 100–200nm sized magnetically functionalized pectin nanocarriers, referred here as MP-OHP nanocarriers. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) studies revealed formation of spherical nanostructures. The magnetic measurements by vibration sample magnetometer (VSM) revealed high saturation magnetization (M s=45.65emu/g). The super...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Applying terahertz technology for nondestructive detection of crack initiation in a film-coated layer on a swelling tablet
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Wataru Momose , Hiroyuki Yoshino , Yoshifumi Katakawa , Kazunari Yamashita , Keiji Imai , Kazuhiro Sako , Eiji Kato , Akiyoshi Irisawa , Etsuo Yonemochi , Katsuhide Terada Here, we describe a nondestructive approach using terahertz wave to detect crack initiation in a film-coated layer on a drug tablet. During scale-up and scale-down of the film coating process, differences in film density and gaps between the film-coated layer and the uncoated tablet were generated due to differences in film coating process parameters, such as the ...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Polymer excipients enable sustained drug release in low pH from mechanically strong inorganic geopolymers
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Erik Jämstorp , Tejaswi Yarra , Bing Cai , Håkan Engqvist , Susanne Bredenberg , Maria Strømme Improving acid resistance, while maintaining the excellent mechanical stability is crucial in the development of a sustained and safe oral geopolymer dosage form for highly potent opioids. In the present work, commercially available Methacrylic acid–ethyl acrylate copolymer, Polyethylene-glycol (PEG) and Alginate polymer excipients were included in dissolved or powder form in geopolymer pellets to improve the release properties of Zolpide...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Oil-in-water emulsion lotion providing controlled release using 2-methacryloyloxyethyl phosphorylcholine n-butyl methacrylate copolymer as emulsifier
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Akiko Ishikawa , Makiko Fujii , Kumi Morimoto , Tomomi Yamada , Naoya Koizumi , Masuo Kondoh , Yoshiteru Watanabe Lotion is a useful vehicle for active ingredients used to treat skin disease because it can be applied to the scalp, can cover large areas of skin, and it is easy to spread due to low viscosity. An emulsion lotion (EL) containing 2-methacryloyloxyethyl phosphorylcholine n-butyl methacrylate copolymer (PMB) as an emulsifier that provides controlled-release was developed. Diphenhydramine (DPH) was used as a model drug. Formul...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Anti-angiogenic poly-L-lysine dendrimer binds heparin and neutralizes its activity
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Khuloud T. Al-Jamal , Wafa T. Al-Jamal , Kostas Kostarelos , John A. Turton , Alexander T. Florence The interaction between heparin, a polyanion, and a polycationic dendrimer with a glycine core and lysine branches Gly–Lys63(NH2)64 has been investigated. Complexation was assessed by transmission electron microscopy, size and zeta potential measurements, methylene blue spectroscopy, and measuring the anti-coagulant activity of heparin in vitro and in vivo. Complete association between the heparin and the dendrimer occurred a 1:1 mass ra...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
The differences between the branded and generic medicines using solid dosage forms: In-vitro dissolution testing
Conclusion Most medicines in this study complied with the pharmacopeial limits. However, some generics dissolved differently than their branded counterparts. This can clearly question the interchangeability between the branded and its generic counterpart or even among generics. (Source: Results in Pharma Sciences)
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments
Publication date: 2013 Source:Results in Pharma Sciences, Volume 3 Author(s): Yutaka Inoue , Rikimaru Maeda , Kayoko Furuya , Murata Isamu , Kimura Masayuki , Ikuo Kanamoto The purpose of this study was to examine the physicochemical properties of TA ointments and conduct a human sensory test to assess the properties of those ointments. Physicochemical assessment was done via near-infrared (NIR) absorption spectroscopy, measurement of water content, microscopy, and measurement of viscoelasticity. The human sensory test examined 5 aspects (texture, cohesiveness, spreadability, smell, and feel). Three TA ointments ...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Surfactants modify the release from tablets made of hydrophobically modified poly (acrylic acid)
This study further investigates the possibility to use CLHMPAA in tablet formulations using ibuprofen as a model substance. Furthermore, surfactants were added to the dissolution medium in order to simulate the presence of bile salts in the intestine. The release of ibuprofen is strongly affected by the presence of surfactant and/or buffer in the dissolution medium, which affect both the behaviour of CLHMPAA and the swelling of the gel layer that surrounds the disintegrating tablets. Two mechanisms of tablet disintegration were observed under shear, namely conventional dissolution of a soluble tablet matrix and erosion of ...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Capsule shell material impacts the in vitro disintegration and dissolution behaviour of a green tea extract
Conclusions The delayed release from studied HPMC capsule materials is likely attributed to an interaction between the catechins, the major constituents of the green tea extract, and the capsule shell material. An assessment of in vitro dissolution is recommended prior to the release of a dietary supplement or clinical trial investigational product to ensure efficacy. Graphical abstract (Source: Results in Pharma Sciences)
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
In vivo siRNA delivery system for targeting to the liver by poly-l-glutamic acid-coated lipoplex
In this study, we developed anionic polymer-coated liposome/siRNA complexes (lipoplexes) with chondroitin sulfate C (CS), poly-l-glutamic acid (PGA) and poly-aspartic acid (PAA) for siRNA delivery by intravenous injection, and evaluated the biodistribution and gene silencing effect in mice. The sizes of CS-, PGA- and PAA-coated lipoplexes were about 200 nm and their ζ-potentials were negative. CS-, PGA- and PAA-coated lipoplexes did not induce agglutination after mixing with erythrocytes. In terms of biodistribution, siRNAs after intravenous administration of cationic lipoplexes were largely observed in the lungs, but t...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Evaluation of formulation properties and skin penetration in the same additive-containing formulation
Publication date: 2014 Source:Results in Pharma Sciences, Volume 4 Author(s): Yutaka Inoue , Kensuke Suzuki , Rikimaru Maeda , Arisa Shimura , Isamu Murata , Ikuo Kanamoto The aim of this study is to examine the physicochemical properties of the external preparation, the effect on the skin permeability and the human senses. Miconazole nitrate cream formulation (MCZ-A: bland name and MCZ-B, −C, −D: generics) to measure the physicochemical properties, was performed by the skin permeation test and human sensory test. The flattening, viscoelasticity, and water content of each cream were measured and each cream wa...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Effect of the excipient concentration on the pharmacokinetics of PM181104, a novel antimicrobial thiazolyl cyclic peptide antibiotic, following intravenous administration to mice
Publication date: 2014 Source:Results in Pharma Sciences, Volume 4 Author(s): Vijayaphanikumar Yemparala , Anagha A. Damre , Venkat Manohar , Kishori Sharan Singh , Girish B. Mahajan , Satish N. Sawant , Tanaji Deokule , H. Sivaramakrishnan Thiazolyl cyclic peptide antibiotics are known for their poor aqueous solubility and unfavorable pharmacokinetics (PK) and hence pose challenging tasks in developing these antibiotics as clinical candidates. In the current paper, we report a possible way to address these challenges with exemplification of our antibiotic PM181104. The approach was to prepare formulations with...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Development and validation of an alternative disturbed skin model by mechanical abrasion to study drug penetration
Publication date: 2014 Source:Results in Pharma Sciences, Volume 4 Author(s): P. Schlupp , M. Weber , T. Schmidts , K. Geiger , F. Runkel Pharmaceuticals and cosmetics for dermal application are usually tested on healthy skin, although the primary permeation barrier, the stratum corneum, is often impaired by skin diseases or small skin lesions, especially on the hands. These skin conditions can considerably influence the permeation of chemicals and drugs. Furthermore, risk assessment for example of nanoparticles should be performed under various skin conditions to reflect the true circumstances. Therefore, an alte...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Biological conversion of aripiprazole lauroxil − An N-acyloxymethyl aripiprazole prodrug
Publication date: 2014 Source:Results in Pharma Sciences, Volume 4 Author(s): Morten Rohde , Niels M⊘rk , Anders E. Håkansson , Klaus G. Jensen , Henrik Pedersen , Tina Dige , Erling B. J⊘rgensen , René Holm N-acyloxyalkylation of NH-acidic compounds can be a prodrug approach for e.g. tertiary or some N-heterocyclic amines and secondary amides and have the potential to modify the properties of the parent drug for specific uses, for example its physicochemical, pharmacokinetic or biopharmaceutical properties. Aripiprazole lauroxil was prepared as a model compound for such prodrugs and its bioconversion wa...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Safety of poly (ethylene glycol)-coated perfluorodecalin-filled poly (lactide-co-glycolide) microcapsules following intravenous administration of high amounts in rats
Publication date: 2014 Source:Results in Pharma Sciences, Volume 4 Author(s): Katja B. Ferenz , Indra N. Waack , Julia Laudien , Christian Mayer , Martina Broecker-Preuss , Herbert de Groot , Michael Kirsch The host response against foreign materials designates the biocompatibility of intravenously administered microcapsules and thus, widely affects their potential for subsequent clinical use as artificial oxygen/drug carriers. Therefore, body distribution and systemic parameters, as well as markers of inflammation and indicators of organ damage were carefully evaluated after administration of short-chained poly...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
