Nanosized ethosomes bearing ketoprofen for improved transdermal delivery
Publication date: May 2011 Source:Results in Pharma Sciences, Volume 1, Issue 1 Author(s): Manish K. Chourasia , Lifeng Kang , Sui Yung Chan The potential of ethosomes for delivering ketoprofen via skin was evaluated. The ethosomes were prepared, optimized and characterized. Vesicular shape, size and entrapment efficiency were determined by transmission electron microscopy, dynamic light scattering and minicolumn centrifugation technique, respectively. Vesicle sizes varied from 120.3±6.1 to 410.2±21.8nm depending on the concentrations of soya phosphatidyl choline (SPC) and ethanol. Entrapment efficiency increased ...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Oral bioavailability of a poorly aqueous drug from three different SBE7-β-cyclodextrin based formulations in beagle dogs
Publication date: May 2011 Source:Results in Pharma Sciences, Volume 1, Issue 1 Author(s): René Holm , Lene Andresen , Claus Strange Oral administration of Lu 35-138, a low aqueous soluble compound, was investigated in three different formulations containing sulfobutylether β-cyclodextrin (SBE7βCD) in fasted beagle dogs. The evaluated formulations was (i) a SBE7βCD solution, (ii) a spray dried solution filled into hard gelatine capsules, and (iii) a direct compressible tablet containing SBE7βCD. The three formulations did not lead any significant differences in the obtained AUCs, though a trend was observed for...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
A simple protocol for preparation of a liposomal vesicle with encapsulated plasmid DNA that mediate high accumulation and reporter gene activity in tumor tissue
Publication date: May 2011 Source:Results in Pharma Sciences, Volume 1, Issue 1 Author(s): Torben Gjetting , Thomas Lars Andresen , Camilla Laulund Christensen , Frederik Cramer , Thomas Tuxen Poulsen , Hans Skovgaard Poulsen The systemic delivery of gene therapeutics by non-viral methods has proven difficult. Transfection systems that are performing well in vitro have been reported to have disadvantageous properties such as rapid clearance and short circulation time often resulting in poor transfection efficiency when applied in vivo. Large unilaminary vesicles (LUV) with encapsulated nucleic acids designated st...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Interaction of artesunate with β-cyclodextrin: Characterization, thermodynamic parameters, molecular modeling, effect of PEG on complexation and antimalarial activity
Publication date: May 2011 Source:Results in Pharma Sciences, Volume 1, Issue 1 Author(s): Renu Chadha , Sushma Gupta , Geeta Shukla , D.V.S. Jain , Raghuvir R.S. Pissurlenkar , Evans C. Coutinho Inclusion of artesunate in the cavity of β-cyclodextrin (β-CD) as well as its methyl and hydroxypropyl derivatives was investigated experimentally and by molecular modeling studies. The effect of PEG on the inclusion was also studied. A 1:1 stoichiometry was indicated by phase-solubility studies both in the presence and absence of PEG and suggested by the mass spectrometry. The mode of inclusion was supported by 2D NMR...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Inclusion complex of a new propiconazole derivative with β-cyclodextrin: NMR, ESI–MS and preliminary pharmacological studies
Publication date: May 2011 Source:Results in Pharma Sciences, Volume 1, Issue 1 Author(s): Narcisa Marangoci , Mihai Mares , Mihaela Silion , Adrian Fifere , Cristian Varganici , Alina Nicolescu , Calin Deleanu , Adina Coroaba , Mariana Pinteala , Bogdan C. Simionescu A novel inclusion complex of the propiconazole nitrate (NO3PCZ) with β-cyclodextrin (β-CD) was prepared by treatment of propiconazole (PCZ) with an acidic nitrating agent. The formation of NO3PCZ and its inclusion complex with β-CD has been studied by NMR, ESI–MS, TGA, DSC methods. Using the undecoupled signal in the HMBC correlation spectr...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Comparative evaluation of humic substances in oral drug delivery
Publication date: May 2011 Source:Results in Pharma Sciences, Volume 1, Issue 1 Author(s): Mohd. Aamir Mirza , Niyaz Ahmad , Suraj Prakash Agarwal , Danish Mahmood , M. Khalid Anwer , Z. Iqbal Major and biologically most explored components of natural organic matter (NOM) are humic acid (HA) and fulvic acid (FA). We have explored rock shilajit as a source of NOM. On the other hand carbamazepine (CBZ) is a well known anticonvulsant drug and has a limited accessibility to brain. Bioavailability and pharmacokinetic profiles of CBZ have been improved by complexation and different techniques also. Present study has as...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Stabilizing effect of citrate buffer on the photolysis of riboflavin in aqueous solution
Publication date: May 2011 Source:Results in Pharma Sciences, Volume 1, Issue 1 Author(s): Iqbal Ahmad , Muhammad Ali Sheraz , Sofia Ahmed , Sadia Hafeez Kazi , Tania Mirza , Mohammad Aminuddin In the present investigation the photolysis of riboflavin (RF) in the presence of citrate species at pH 4.0–7.0 has been studied. A specific multicomponent spectrophotometric method has been used to assay RF in the presence of photoproducts during the reactions. The overall first-order rate constants (k obs ) for the photolysis of RF range from 0.42 to 1.08×10–2 min−1 in the region. The values of k obs have been ...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Study of particle rearrangement, compression behavior and dissolution properties after melt dispersion of ibuprofen, Avicel and Aerosil
Publication date: May 2011 Source:Results in Pharma Sciences, Volume 1, Issue 1 Author(s): Subrata Mallick , Saroj Kumar Pradhan , Muronia Chandran , Manoj Acharya , Tanmayee Digdarsini , Rajaram Mohapatra Particle rearrangements, compaction under pressure and in vitro dissolution have been evaluated after melt dispersion of ibuprofen, Avicel and Aerosil. The Cooper–Eaton and Kuno equations were utilized for the determination of particle rearrangement and compression behavior from tap density and compact data. Particle rearrangement could be divided into two stages as primary and secondary rearrangement. Transi...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Publisher Note
Publication date: May 2011 Source:Results in Pharma Sciences, Volume 1, Issue 1 (Source: Results in Pharma Sciences)
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Moraima Morales-Cruz , Giselle M. Flores-Fernández , Myreisa Morales-Cruz , Elsie A. Orellano , José A. Rodriguez-Martinez , Mercedes Ruiz , Kai Griebenow One of the first methods to encapsulate drugs within polymer nanospheres was developed by Fessi and coworkers in 1989 and consisted of one-step nanoprecipitation based on solvent displacement. However, proteins are poorly encapsulated within polymer nanoparticles using this method because of their limited solubility in organic solvents. To overcome this limitation, we developed a t...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Regenerated keratin membrane to match the in vitro drug diffusion through human epidermis
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Francesca Selmin , Francesco Cilurzo , Annalisa Aluigi , Silvia Franzè , Paola Minghetti This work aimed to develop membranes made of regenerated keratin and ceramides (CERs) to match the barrier property of the human stratum corneum in in vitro percutaneous absorption studies. The membrane composition was optimized on the basis of the in vitro drug diffusion profiles of ibuprofen, propranolol and testosterone chosen as model drugs on the basis of their different diffusion and solubility properties. The data were compared to those obtai...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Moxifloxacin in situ gelling microparticles–bioadhesive delivery system
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Qiongyu Guo , Ahmed Aly , Oliver Schein , Morgana M. Trexler , Jennifer H. Elisseeff Antibiotic use for ocular treatments has been largely limited by poor local bioavailability with conventional eyedrops formulations. Here, we developed a controlled delivery system composed of moxifloxacin-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulated in a chondroitin sulfate-based, two-component bioadhesive hydrogel. Using a simple and fast electrohydrodynamic spray drying (electrospraying) technique, surfactant-free moxifloxac...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Enzymatic mono-pegylation of glucagon-like peptide 1 towards long lasting treatment of type 2 diabetes
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Fabio Selis , Rodolfo Schrepfer , Riccardo Sanna , Silvia Scaramuzza , Giancarlo Tonon , Simona Dedoni , Pierluigi Onali , Gaetano Orsini , Stefano Genovese Human glucagon-like peptide-1 (GLP-1) is a physiological gastrointestinal peptide with glucose-dependent insulinotropic effects which is therefore considered an interesting antidiabetic agent. However, after in vivo administration, exogenous GLP-1 does not exert its physiological action due to the combination of rapid proteolytic degradation by ubiquitous dipeptidyldipeptidase IV...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Release behavior of trans,trans-farnesol entrapped in amorphous silica capsules
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Filipa L. Sousa , Sara Horta , Magda Santos , Sĺlvia M. Rocha , Tito Trindade Farnesol, a compound widely found in several agro-food by-products, is an important bioactive agent that can be exploited in cosmetics and pharmaceutics but the direct bioapplication of this compound is limited by its volatility. Here the entrapment of farnesol in silica capsules was investigated to control the release of this bioactive compound in the vapor phase and in ethanol solutions. The preparation of silica capsules with oil cores was obtained by emplo...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
Glycosylation improves a-chymotrypsin stability upon encapsulation in poly(lactic-co-glycolic)acid microspheres
Publication date: 2012 Source:Results in Pharma Sciences, Volume 2 Author(s): Giselle M. Flores-Fernández , Kai Griebenow Enhancing protein stability upon encapsulation and release from polymers is a key issue in sustained release applications. In addition, optimum drug dispersion in the polymer particles is critical for achieving release profiles with low unwanted initial “burst” release. Herein, we address both issues by formulating the model enzyme a-chymotrypsin (a-CT) as nanoparticles to improve drug dispersion and by covalently modifying it with glycans to afford improved stability during encapsulation in ...
Source: Results in Pharma Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research
