Acute low-dose bisphenol S exposure affects mouse oocyte quality
Publication date: Available online 24 December 2019Source: Reproductive ToxicologyAuthor(s): Šárka Prokešová, Kamar Ghaibour, František Liška, Pavel Klein, Tereza Fenclová, Miriama Štiavnická, Petr Hošek, Tereza Žalmanová, Kristýna Hošková, Hedvika Řimnáčová, Jaroslav Petr, Milena Králíčková, Jan NevoralABSTRACTBisphenol S (BPS) is widely used to replace the known endocrine disruptor BPA in various products. We evaluated the effect of acute in vivo BPS exposure on oocyte quality, simulating the oral route of exposure via oral gavage. Eight-week-old ICR female mice (N = 15 per experimental group) ...
Source: Reproductive Toxicology - December 24, 2019 Category: Toxicology Source Type: research
Editorial Board
Publication date: December 2019Source: Reproductive Toxicology, Volume 90Author(s): (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - November 29, 2019 Category: Toxicology Source Type: research
Maternal folic acid and micronutrient supplementation is associated with vitamin levels and symptoms in children with autism spectrum disorders
Publication date: Available online 21 November 2019Source: Reproductive ToxicologyAuthor(s): Mei Tan, Ting Yang, Jiang Zhu, Qiu Li, Xi Lai, Yuanyuan Li, Ting Tang, Jie Chen, Tingyu LiAbstractTo explore possible associations between maternal use of micronutrient supplements and the subsequent vitamin levels and symptoms in offspring with autism spectrum disorder (ASD), a total of 416 children with ASD and 201 typically developing (TD) children were enrolled. The children born to mothers without folic acid (FA) and micronutrient supplementation during pregnancy had more severe social cognition impairments, social communicati...
Source: Reproductive Toxicology - November 22, 2019 Category: Toxicology Source Type: research
Fetal Bisphenol A and Ethinylestradiol Exposure Alters Male Rat Urogenital Tract Morphology at Birth: Confirmation of Prior Low-Dose Findings in CLARITY-BPA
Publication date: Available online 19 November 2019Source: Reproductive ToxicologyAuthor(s): Kristen S. Uchtmann, Julia A. Taylor, Barry G. Timms, Richard W. Stahlhut, Emily A. Ricke, Mark R. Ellersieck, Frederick S. vom Saal, William A. RickeAbstractBisphenol A (BPA) is a contaminant in virtually all Americans. To examine BPA’s adverse effects, the FDA-NCTR, NIEHS, and 14 groups of academic scientists formed a consortium: CLARITY-BPA. The purpose of our study was to investigate the effects of a wide range of doses of BPA on fetal development of the NCTR CD-SD male rat urogenital sinus (UGS). Pregnant rats were administe...
Source: Reproductive Toxicology - November 20, 2019 Category: Toxicology Source Type: research
Elevated blood mercury level has a non-linear association with infertility in U.S. women: data from the NHANES 2013-2016
Publication date: Available online 19 November 2019Source: Reproductive ToxicologyAuthor(s): Fangfang Zhu, Chi Chen, Yingxuan Zhang, Si Chen, Xian Huang, Jingwei Li, Yanxi Wang, Xiaorong Liu, Gaopi Deng, Jie GaoAbstractMercury is a ubiquitous toxic heavy metal associated with an increased risk of female infertility; however, the evidence supporting this is limited and controversial. We aimed to explore the relationship between the total blood mercury and infertility in 1796 selected participants from the National Health and Nutrition Examination Survey (NHANES) (2013-2016). We found no significant association between mercu...
Source: Reproductive Toxicology - November 20, 2019 Category: Toxicology Source Type: research
The effects of caffeine and bisphenol A singularly or in combination on cultured mouse embryos and yolk sac placenta
In this study, mouse embryos (embryonic day 8.5) surrounded by yolk sac placenta were cultured with caffeine (30, 60, and 120 μg/ml) and/or BPA (35 μg/ml) for 48 hours. In response to a single administration of BPA or caffeine dose, embryonic development was similar to normal control embryos. However, the combined exposure to caffeine and BPA dose-dependently increased embryonic anomalies, and thinner ventricular wall and trabeculae disorders of heart were observed. The mRNA levels of various anti-oxidative, apoptotic, and hypoxic genes were significantly altered in the treated embryos. Furthermore, abnormal vascul...
Source: Reproductive Toxicology - November 20, 2019 Category: Toxicology Source Type: research
Role of microtubule +TIPs and -TIPs in spermatogenesis – insights from studies of toxicant models
Publication date: Available online 19 November 2019Source: Reproductive ToxicologyAuthor(s): Bai-ping Mao, Renshan Ge, C. Yan ChengAbstractDuring spermatogenesis, preleptotene spermatocytes and haploid spermatids, lacking lamellipodia and filopodia to elicit cell movement rely on Sertoli cells for transport across the blood-testis barrier (BTB) and the adluminal compartment of the epithelium, respectively. Tracks provided by microtubules (MTs) across the epithelium are essential to support germ cell transport, but the mechanism(s) remain elusive. Studies have provided insightful information through the use of toxicant mode...
Source: Reproductive Toxicology - November 19, 2019 Category: Toxicology Source Type: research
Anchoring a dynamic in vitro model of human neuronal differentiation to key processes of early brain development in vivo
Publication date: Available online 16 November 2019Source: Reproductive ToxicologyAuthor(s): Susanna H. Wegner, Julie Juyoung Park, Tomomi Workman, Sanne A.B. Hermsen, Jim Wallace, Ian B. Stanaway, Hee Yeon Kim, William C. Griffith, Sungwoo Hong, Elaine M. FaustmanAbstractWe characterize temporal pathway dynamics of differentiation in an in vitro neurotoxicity model with the aim of informing design and interpretation of toxicological assays. Human neural progenitor cells (hNPCs) were cultured in differentiation conditions up to 21 days. Genes significantly changed through time were identified and grouped according to tempo...
Source: Reproductive Toxicology - November 16, 2019 Category: Toxicology Source Type: research
Message from the Editor-in-Chief
Publication date: Available online 16 November 2019Source: Reproductive ToxicologyAuthor(s): Anna Bal-Price (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - November 16, 2019 Category: Toxicology Source Type: research
Placental Morphometry in Relation to Daughters’ Percent Mammographic Breast Density at Midlife
Publication date: Available online 9 November 2019Source: Reproductive ToxicologyAuthor(s): Barbara A. Cohn, Piera M. Cirillo, Nickilou Y. Krigbaum, Lauren M. Zimmermann, Julie D. Flom, Mary Beth TerryABSTRACTIntrauterine and early-life exposures, including intrauterine smoke exposures and infant growth are associated with mammographic breast density (MBD), a strong breast cancer risk factor. We investigated whether placental morphometry which is affected by intrauterine smoke exposure and also influences infant growth predicts %MBD at ages 37-47. In 247 daughters in the Child Health and Development Studies, we found that ...
Source: Reproductive Toxicology - November 10, 2019 Category: Toxicology Source Type: research
Alcohol intake during pregnancy and timing of puberty in sons and daughters: a nationwide cohort study
Publication date: Available online 8 November 2019Source: Reproductive ToxicologyAuthor(s): Nis Brix, Lea L.B. Lauridsen, Andreas Ernst, Jørn Olsen, Tine B. Henriksen, Cecilia H. Ramlau-HansenAbstractWe explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000–2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012–2018. Information on maternal average alcoho...
Source: Reproductive Toxicology - November 9, 2019 Category: Toxicology Source Type: research
In Utero DDT Exposure and Breast Density Before Age 50
Publication date: Available online 8 November 2019Source: Reproductive ToxicologyAuthor(s): Nickilou Y. Krigbaum, Piera M. Cirillo, Julie D. Flom, Jasmine A. McDonald, Mary Beth Terry, Barbara A. CohnAbstractPrior studies in the Child Health and Development Studies (CHDS) found in utero exposure to the pesticide, dichlorodiphenyltrichloroethane (DDT), increased breast cancer risk by age 52. Mammographic density is considered a primary risk factor for breast cancer. We conducted a study of 309 daughters from the CHDS to examine in utero DDT exposure and mammographic density in midlife. Among daughters with high (>75th perce...
Source: Reproductive Toxicology - November 9, 2019 Category: Toxicology Source Type: research
Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells
Publication date: Available online 8 November 2019Source: Reproductive ToxicologyAuthor(s): Yusuke Marikawa, Hong-Ru Chen, Mark Menor, Youping Deng, Vernadeth B. AlarconAbstractPluripotent stem cells recapitulate many aspects of embryogenesis in vitro. Here, we established a novel culture system to differentiate human embryonic stem cell aggregates (HESCA), and evaluated its utility for teratogenicity assessment. Culture of HESCA with modulators of developmental signals induced morphogenetic and molecular changes associated with differentiation of the paraxial mesoderm and neuroectoderm. To examine impact of teratogenic ex...
Source: Reproductive Toxicology - November 9, 2019 Category: Toxicology Source Type: research
Abnormal retinal pigment epithelium melanogenesis as a major determinant for radiation-induced congenital eye defects
Publication date: Available online 6 November 2019Source: Reproductive ToxicologyAuthor(s): Kai Craenen, Mieke Verslegers, Livine Craeghs, Roel Quintens, Ann Janssen, Amelie Coolkens, Sarah Baatout, Lieve Moons, Mohammed Abderrafi BenotmaneAbstractRecent studies highlighted a link between ionizing radiation exposure during neurulation and birth defects such as microphthalmos and anophthalmos. Because the mechanisms underlying these defects remain largely unexplored, we irradiated pregnant C57BL/6J mice (1.0 Gy, X-rays) at embryonic day (E)7.5, followed by histological and gene/protein expression analyses at defined days. I...
Source: Reproductive Toxicology - November 7, 2019 Category: Toxicology Source Type: research
“Simulect” as a model compound for assessing placental transfer of monoclonal antibodies in minipigs
Publication date: Available online 4 November 2019Source: Reproductive ToxicologyAuthor(s): Adam Hey, Marilyn Hill, Claudio Calonder, Anthony M DeLise, Anette B Grossi, Celine Pique, Edward MarsdenAbstractThe aim of this study was to directly test and measure in vivo, if placental transfer of monoclonal antibodies takes place in pregnant Göttingen Minipigs to assess their suitability for reproductive assessment of therapeutic monoclonal antibodies.Simulect®, an approved anti CD25 (anti IL-2 receptor alpha) chimeric monoclonal IgG1 antibody, was used as a model monoclonal antibody. Maternal systemic exposure and potential...
Source: Reproductive Toxicology - November 6, 2019 Category: Toxicology Source Type: research
