Delta and Kappa opioid receptors on mouse sperm cells: expression, localization and involvement on in vitro fertilization
Publication date: Available online 4 March 2020Source: Reproductive ToxicologyAuthor(s): Estibaliz Olabarrieta, Lide Totorikaguena, Jon Romero-Aguirregomezcorta, Naiara Agirregoitia, Ekaitz Agirregoitia (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - March 5, 2020 Category: Toxicology Source Type: research
Brominated diphenyl ether-47 differentially regulates cellular migration and invasion in a human first trimester trophoblast cell line
Publication date: Available online 3 March 2020Source: Reproductive ToxicologyAuthor(s): Hae-Ryung Park, Elana R. Elkin, Marisol Castillo-Castrejon, Rita Loch-Caruso (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - March 4, 2020 Category: Toxicology Source Type: research
Prenatal Exposure to a Phthalate Mixture Leads to Multigenerational and Transgenerational Effects on Uterine Morphology and Function in Mice
Publication date: Available online 29 February 2020Source: Reproductive ToxicologyAuthor(s): Kailiang Li, Monika Liszka, Changqing Zhou, Emily Brehm, Jodi A. Flaws, Romana A. Nowak (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - March 1, 2020 Category: Toxicology Source Type: research
Predicting the Safety of Medicines in Pregnancy: a Workshop Report
Publication date: Available online 29 February 2020Source: Reproductive ToxicologyAuthor(s): J.M. Clements, R.G. Hawkes, D. Jones, A. Adjei, T. Chambers, L. Simon, H. Stemplewski, N. Berry, S. Price, M. Pirmohamed, A.H. Piersma, G. Waxenecker, P. Barrow, M.E.W. Beekhuijzen, A. Fowkes, H. Prior, F. Sewell (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - March 1, 2020 Category: Toxicology Source Type: research
Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs
Publication date: Available online 28 February 2020Source: Reproductive ToxicologyAuthor(s): Ségolène Siméon, Katharina Brotzmann, Ciaran Fisher, Iain Gardner, Steve Silvester, Richard Maclennan, Paul Walker, Thomas Braunbeck, Frederic Y. Bois (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - February 28, 2020 Category: Toxicology Source Type: research
Retinoic acid induced cytokines are selectively modulated by Liver X Receptor activation in zebrafish
Publication date: Available online 25 February 2020Source: Reproductive ToxicologyAuthor(s): Oscar E. Diaz, Shuangjia Xue, Xinxin Luo, Joel Nava, Anders Appelblom, Rodrigo A. Morales, Srustidhar Das, Eduardo J. Villablanca (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - February 26, 2020 Category: Toxicology Source Type: research
Dioxin Male Rat Reproductive Toxicity Mode of Action and Relative Potency of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2,3,7,8-Tetrachlorodibenzofuran Characterized by Fetal Pituitary and Testis Transcriptome Profiling
Publication date: Available online 25 February 2020Source: Reproductive ToxicologyAuthor(s): Kamin J. Johnson, Julie Passage, Hui Lin, Shreedharan Sriram, Robert A. Budinsky (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - February 26, 2020 Category: Toxicology Source Type: research
CHDS: A National Treasure that Keeps on Giving
Publication date: Available online 22 February 2020Source: Reproductive ToxicologyAuthor(s): Suzanne E. Fenton, Linda S. Birnbaum (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - February 23, 2020 Category: Toxicology Source Type: research
Chronic Kidney Disease in Pregnant Mothers affects Maternal and Fetal Disposition of Mercury
Publication date: Available online 19 February 2020Source: Reproductive ToxicologyAuthor(s): Renee F. Moss, Hannah S. George, Sanya Nijhara, Sarah E. Orr, Lucy Joshee, Jennifer L. Barkin, Christy C. BridgesAbstractChronic kidney disease (CKD) affects over 15% of the adults in the United States. Pregnant women with CKD present an additional challenge in that they are at increased risk for adverse events such as preterm birth. Exposure to environmental toxicants, such as methylmercury, may exacerbate maternal disease and increase the risk of adverse fetal outcomes. We hypothesized that fetuses of mothers with CKD are more su...
Source: Reproductive Toxicology - February 19, 2020 Category: Toxicology Source Type: research
Review of the environmental prenatal exposome and its relationship to maternal and fetal health
Publication date: Available online 12 February 2020Source: Reproductive ToxicologyAuthor(s): Julia E. Rager, Jacqueline Bangma, Celeste Carberry, Alex Chao, Jarod Grossman, Kun Lu, Tracy A. Manuck, Jon R. Sobus, John Szilagyi, Rebecca C. FryAbstractEnvironmental chemicals comprise a major portion of the human exposome, with some shown to impact the health of susceptible populations, including pregnant women and developing fetuses. The placenta and cord blood serve as important biological windows into the maternal and fetal environments. In this article we review how environmental chemicals (defined here to include man-made...
Source: Reproductive Toxicology - February 14, 2020 Category: Toxicology Source Type: research
Vitamin K antagonist rodenticides display different teratogenic activity
Publication date: Available online 8 February 2020Source: Reproductive ToxicologyAuthor(s): Chetot Thomas, Shira Taufana, Benoit Etienne, Lattard VirginieAbstractVitamin K antagonists (VKA) are not recommended during pregnancy because warfarin (a first-generation VKA) is associated with a malformation syndrome “the fetal warfarin syndrome” (FWS). VKA are also used for rodent management worldwide. Recently, the Committee for Risk Assessment responsible for the European chemical legislation for advances on the safe use of chemicals had classed 8 anticoagulant used as rodenticides in the reprotoxic category 1A or 1B. This...
Source: Reproductive Toxicology - February 9, 2020 Category: Toxicology Source Type: research
Male Infertility: A Proximate Look at the Advanced Glycation End Products
Publication date: Available online 9 February 2020Source: Reproductive ToxicologyAuthor(s): Temidayo S. Omolaoye, Stefan S. du PlessisAbstractAdvanced glycation end products (AGEs) are products of cascades of non-enzymatic glycosylation. They are formed over a period of hours to days, depending on the protein lifetime. AGEs acts by independently producing reactive oxygen species (ROS) or by binding to their receptors. Binding of AGE to the receptor for advanced glycation end products (RAGE) has been shown to play a role in physiological processes, including lung homeostasis, bone metabolism, neuronal systems and the immune...
Source: Reproductive Toxicology - February 9, 2020 Category: Toxicology Source Type: research
The environment, windows of susceptibility, and breast cancer
Publication date: Available online 5 February 2020Source: Reproductive ToxicologyAuthor(s): Marion H.E. Kavanaugh-Lynch (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - February 6, 2020 Category: Toxicology Source Type: research
A closed vitrification system enables a murine ovarian follicle bank for high-throughput ovotoxicity screening, which discovers the endocrine disrupting effect of microcystins
Publication date: Available online 1 February 2020Source: Reproductive ToxicologyAuthor(s): Yingzheng Wang, Jingshan Xu, Jessica E. Stanley, Murong Xu, Bryan W. Brooks, Geoffrey I. Scott, Saurabh Chatterjee, Qiang Zhang, Mary B. Zelinski, Shuo XiaoAbstractIncreasing evidence reveals that a broad spectrum of environmental chemicals and pharmaceutical compounds cause female ovarian toxicity (ovotoxicity). The current gold standard of ovotoxicity testing largely relies on whole laboratory animals, but in vivo models are time consuming, costly, and present animal welfare concerns. We previously demonstrated that the 3D encapsu...
Source: Reproductive Toxicology - February 2, 2020 Category: Toxicology Source Type: research
Copper and Lead Exposures Disturb Reproductive Features of Primary Endometrial Stromal and Epithelial Cells
This study investigates if Cu and Pb act as endocrine disruptors affecting endometrial cells. Primary EnSCs and EnECs were exposed to Cu (0, 50, 100 and 200 µM) or Pb (0, 30, 100 and 500 µM) and assessed for viability, decidualization, apoptosis and proliferation on EnSCs, and wound healing and adhesion capabilities on EnECs. Cu exposure decreased significantly cell viability in a dose-dependent manner. Cu and Pb negatively affected in vitro decidualization, showing a significant decrease in PRL secretion. HOXA10 and ERα mRNA levels significantly decreased in decidualized cells (dEnSCs) exposed to Cu. Cu and Pb decrease...
Source: Reproductive Toxicology - January 29, 2020 Category: Toxicology Source Type: research
