Short-term toxicogenomics as an alternative approach to chronic in vivo studies for derivation of points of departure: A case study in the rat with a triazole fungicide
Publication date: Available online 5 April 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Jessica LaRocca, Eduardo Costa, Shreedharan Sriram, Bethany Hannas, Kamin J. Johnson (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - April 6, 2020 Category: Toxicology Source Type: research

Cyto-genotoxic evaluation of novel anti-tubercular copper (II) complexes containing isoniazid-based ligands
Publication date: Available online 5 April 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Nathália Ferreira Fregonezi, Fabiana Aparecida de Souza, Nadia Andrade Aleixo, Pietra Stefany da Silva Gomes, Rafaela Baldassari Silvestre, Rone Aparecido De Grandis, Patricia Bento da Silva, Fernando Rogério Pavan, Marlus Chorilli, Flavia Aparecida Resende (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - April 5, 2020 Category: Toxicology Source Type: research

A semi-automated workflow for adverse outcome pathway hypothesis generation: The use case of non-genotoxic induced hepatocellular carcinoma
Publication date: Available online 3 April 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Tatyana Y. Doktorova, Noffisat O. Oki, Tomaž Mohorič, Thomas E. Exner, Barry Hardy (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - April 4, 2020 Category: Toxicology Source Type: research

The limitations of using the NTP chronic bioassay on vanadium pentoxide in risk assessments
Publication date: Available online 1 April 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Judith A. MacGregor, David J. White, Amy Lavin Williams (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - April 2, 2020 Category: Toxicology Source Type: research

Nonclinical safety assessment of repeated administration and biodistribution of a novel rabies self-amplifying mRNA vaccine in rats
Publication date: Available online 30 March 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Alan Stokes, Johanne Pion, Ornella Binazon, Benoit Laffont, Maude Bigras, Guillaume Dubois, Karine Blouin, Jamie K. Young, Michael A. Ringenberg, Nawel Ben Abdeljelil, Julius Haruna, Luis-Alexander Rodriguez (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - April 1, 2020 Category: Toxicology Source Type: research