Recent Patents on Endocrine, Metabolic and Immune Drug Discovery This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Medicinal and healthical applications of Tinospora cordifolia (Guduchi): A miraculous herb countering various diseases, disorders, and potentials as an immune booster.
CONCLUSIONS: The information presented would be beneficial for researchers, medical professionals and pharmaceutical companies to design and develop effective medicines, drugs and healthical products exploiting the multiple as well as specific modes of actions of T. cordifolia, and also help in promoting and popularizing this rich herb having promising potentials to prevent and treat various ailments. PMID: 28260522 [PubMed - as supplied by publisher] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - March 8, 2017 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Role Of Iodine In Metabolism.
Authors: Zbigniew S Abstract The natural resources of iodine are seawater, seaweeds and saltpeter-nitrate deposits in Chile. Over 1/3 of the global population is exposed to iodine deficiency, especially in the mountains. Iodine is a component of the thyroid hormones and a strong antioxidant with electric potential of -0.54 V. Iodine as iodide is taken up by the thyroid gland, gastric mucosa, salivary glands and mammary glands in pregnant and breast-feeding women. The transport of iodine to the thyroid gland is regulated by specific enzymes: Natrium-Iodine Symporter, Na+/K+ATP-ase, Pendrin and Apical Iodine...
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - January 21, 2017 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

The Role Of The World Health Organization In Eliminating Iodine Deficiency Worldwide.
CONCLUSION: WHO has coordinated and fostered collaboration between countries, international organizations, scientific associations and non-governmental organization to reach the goal of eliminating iodine deficiency. PMID: 28103778 [PubMed - as supplied by publisher] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - January 21, 2017 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Psychopathological behaviour and cognition in morbid obesity.
CONCLUSION: Psychological, psychoeducational and psychopharmacological treatment can facilitate weight loss in morbid obese subjects with psychopathological comorbidities. A precise definition of the mechanisms affecting appetite, satiety and energy balance is expected to foster the development of new effective antiobesity drugs. PMID: 28029083 [PubMed - as supplied by publisher] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - December 30, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Editorial (Thematic Issue: Endocrine Disorders and Cognitive Function in the Elderly).
Authors: Pasqualetti G, Calsolaro V, Monzani F PMID: 27981913 [PubMed - in process] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - December 18, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Serum Testosterone and Cognitive Function in Ageing Male: Updating the Evidence.
CONCLUSIONS: Studies aiming to evaluate the role of serum T and its supplementation in adult and ageing men with T deficiency syndrome need to be encouraged, given that subjects affected by overt hypogonadism, either in prepubertal (i.e. Klinefelter syndrome) or postpubertal forms (chemical castration in subjects affected by prostate cancer), often complain of cognitive dysfunction, and seem to considerably benefit from T replacement therapy. PMID: 27981914 [PubMed - in process] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - December 18, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Galectin-9 in cancer therapy.
Authors: Fujihara S, Mori H, Kobara H, Rafiq K, Niki T, Hirashima M, Masaki T Abstract Galectin-9 is a tandem-repeat type galectin with two carbohydrate-recognition domains, and it was first identified as an eosinophil chemoattractant and activation factor. Subsequent studies revealed that galectin-9, similar to other galectins, modulates a variety of biological functions including cell aggregation and adhesion, as well as apoptosis of tumor cells. Galectin-9 has recently been shown to have an anti-proliferative effect on cancer cells. Recent studies have uncovered additional mechanisms by which T cell imm...
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - November 27, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

The Regulatory Roles of Mitogen-activated Protein Kinase (MAPK) Pathways in Health and Diabetes: Lessons Learned from the Pancreatic β-cell.
CONCLUSIONS: The MAPK pathways are activated in presence of various stress stimuli including intracellular ROS, via distinct signaling cascades. Once activated, MAPKs participate in specific intracellular signaling processes via interaction with several downstream kinases including the MAPK-activated protein kinases (MAPKAPKs) and transcription factors including c-jun and p53. We have provided an overview of existing evidence in the islet β-cell on the regulatory roles of these MAPKs in mediating cellular responses to alterations in intracellularly generated ROS, which is mediated by the Rac1-Nox2 signaling module. Additi...
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - October 26, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Real Time Polymerase Chain Reaction (rt-PCR): A New Patent to diagnostic purposes for paracoccidioidomycosis.
CONCLUSION: The reaction developed was standardized and patented opening perspectives to molecular diagnosis development for paracoccidioidomycosis, since rt-PCR can be applied to a broad spectrum of infectious diseases. It would need to be tested in biological samples in order to validate this method and then generate a diagnostic kit for Paracoccidioidomycosis. PMID: 27593543 [PubMed - as supplied by publisher] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - September 7, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Cushing's Syndrome And Steroid Dementia.
Authors: Bernini G, Tricò D Abstract Background Cushing's Syndrome (CS) is associated with a specific spectrum of dementia-like symptoms, including psychiatric disorders, such as major depression, anxiety and mania, and neurocognitive alterations, like impairment of memory and concentration. This pattern of clinical complications, which significantly impair the health-related quality of life of CS patients, is sometimes referred to as "steroid dementia syndrome" (SDS). The SDS is the result of anatomical and functional anomalies in brain areas involved in the processing of emotion and cognition, which are...
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - August 17, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Parkinson's Disease, Diabetes and Cognitive Impairment.
CONCLUSION: Further studies using GLP-1 agonists and DPP-4 inhibitors to treat PD are warranted as they have shown promise. PMID: 27396477 [PubMed - as supplied by publisher] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - July 13, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Cognitive Function and the Ageing Process: The Peculiar Role of Mild Thyroid Failure.
Conclusion The available data suggest a complex relationship between mild thyroid failure and the ageing process as well as the development and progression of several cardiovascular and neurological diseases. In this paper, we reviewed the scientific English literature on sHT and the ageing process focusing on experimental evidences related to cognitive impairment and dementia. Moreover, we focused on new patents of treatments potentially able to improve the care of sHT patients, especially in the elderly, where treatment drawbacks may have negative impact on the long term outcome. PMID: 27396589 [PubMed - as suppl...
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - July 13, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Alterations in glucose metabolism in Alzheimer's disease.
CONCLUSIONS: Early diagnosis and early therapeutic intervention are needed to approach this devastating disease. Important studies targeting different aspect of the disease are currently ongoing. PMID: 27306508 [PubMed - as supplied by publisher] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - June 18, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Cognitive function and heart failure: the role of the adrenergic system.
CONCLUSION: We have discussed recent findings allowing the identification of new molecular targets that hopefully will contribute to the generation of effective therapeutic strategies for HF and dementia. In this article the patents Us20100048479, Us7060871, Wo2006052857, Us7351401, Us5721243, Wo1994009155, Us5449604, Wo1999058981, Us5985581, EP2319511, EP2377534, EP2650303, WO2006004939, WO2010132128 and EP1779858 are summarized. PMID: 27173155 [PubMed - as supplied by publisher] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - May 14, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

New Method of Inhibition of Activity of Tumor Necrosis Factor Alpha In Patients with Psoriasis.
CONCLUSION: The method of reduction of tumor necrosis factor alpha activity is recommended for implementation into clinical practice. PMID: 27112330 [PubMed - as supplied by publisher] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - April 28, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research