The Regulatory Roles of Mitogen-activated Protein Kinase (MAPK) Pathways in Health and Diabetes: Lessons Learned from the Pancreatic β-cell.

CONCLUSIONS: The MAPK pathways are activated in presence of various stress stimuli including intracellular ROS, via distinct signaling cascades. Once activated, MAPKs participate in specific intracellular signaling processes via interaction with several downstream kinases including the MAPK-activated protein kinases (MAPKAPKs) and transcription factors including c-jun and p53. We have provided an overview of existing evidence in the islet β-cell on the regulatory roles of these MAPKs in mediating cellular responses to alterations in intracellularly generated ROS, which is mediated by the Rac1-Nox2 signaling module. Additionally, we enlisted recent patents developed to improve β-cell function in diabetes and novel pharmacological agents that target oxidative stress and MAPK pathways.
PMID: 27779078 [PubMed - as supplied by publisher]

Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - October 26, 2016 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research