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Patents on Potential Drugs to Treat Alzheimer's Disease: Special Emphasis on Small Peptides.
Authors: Sundaram P, Nambiar AK, Sundaram RK Abstract The primary objective of this article is to review patents and the related scientific work on naturally occurring compounds, heterocyclic compounds and small peptides that are being explored for their utility for the treatment of Alzheimer's disease (AD). In this review, a special emphasis is given to the patents, including our patient issued in 2013, on peptides that bind to Ab. Utility of the peptides that prevent aggregation or those that help in clearance of Ab is discussed as the later can be considered as an important arm in combination therapy fo...
Source: Recent Patents on CNS Drug Discovery - November 20, 2014 Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research

Advancing Drug Therapy for Brain Tumours: A Current Review of the Pro-Inflammatory Peptide Substance P and its Antagonists as Anti-Cancer Agents.
Authors: Mander K, Harford-Wright E, Lewis KM, Vink R Abstract Evidence for the involvement of the Substance P (SP)/NK1 receptor system in the development and progression of cancer strongly supports its potential as a therapeutic target in malignancies. Novel strategies for approaching cancer treatment are urgently required particularly with regard to tumours of the central nervous system (CNS), which are notoriously difficult to effectively treat and associated with extremely poor prognosis for many patients. This is due, in part, to the presence of the highly specialised blood-brain barrier, which is kno...
Source: Recent Patents on CNS Drug Discovery - November 20, 2014 Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research

Possible Physiopathological Effects of the Transglutaminase Activity on the Molecular Mechanisms Responsible for Human Neurodegenerative Diseases.
Authors: Iannaccone M, Titta F, Serretiello E, Monfregola M, Gentile V Abstract Transglutaminases are a class of ubiquitous enzymes which catalyze post-translational modifications of proteins. The main activity of these enzymes is the cross-linking of glutaminyl residues of a protein/peptide substrate to lysyl residues of a protein/peptide co-substrate. In addition to lysyl residues, other second nucleophilic co-substrates may include monoamines or polyamines (to form mono- or bi-substituted /crosslinked adducts) or -OH groups (to form ester linkages). In absence of co-substrates, the nucleophile may be wa...
Source: Recent Patents on CNS Drug Discovery - November 20, 2014 Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research