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Tale of tail current
Publication date: Available online 22 June 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Sodikdjon A. KodirovAbstractThe largest biomass of channel proteins is located in unicellular organisms and bacteria that have no organs. However, orchestrated bidirectional ionic currents across the cell membrane via the channels are important for the functioning of organs of organisms, and equally concern both fauna or flora. Several ion channels are activated in the course of action potentials. One of the hallmarks of voltage-dependent channels is a ‘tail current’ − deactivation as observed after prior...
Source: Progress in Biophysics and Molecular Biology - June 24, 2019 Category: Molecular Biology Source Type: research

PCL/EUG Scaffolds with Tunable Stiffness Can Regulate Macrophage Secretion Behavior
In this study, polycaprolactone (PCL) and Eucommia Ulmoides Gum (EUG) composite scaffolds were first fabricated by electrospinning. The stiffness of as-fabricated scaffolds was altered by adjusting the PCL-to-EUG ratio. The mechanical properties, structural characteristics and chemical composition of the scaffolds were investigated using various materials characterization techniques. The results show that stiffness of the scaffolds was in the same range as that of cartilage tissues with OA. Confocal microscopy and reverse transcription-polymerase chain reaction (RT-PCR) were performed to investigate the macrophages culture...
Source: Progress in Biophysics and Molecular Biology - June 19, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: July 2019Source: Progress in Biophysics and Molecular Biology, Volume 144Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - June 7, 2019 Category: Molecular Biology Source Type: research

Screening of pharmacological uses of Urtica dioica and others benefits
ConclusionThe nettle is actually a plant with many qualities and uses. The interest in it is deserved and it is given by other studies and investigations. (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - June 1, 2019 Category: Molecular Biology Source Type: research

In-situ optical assessment of rat epicardial kinematic parameters reveals frequency-dependent mechanic heterogeneity related to gender
ConclusionOur innovative technology was capable to evaluate in-situ rat epicardial kinematic at high stimulation frequency, revealing that male preserved kinematic parameters but varying the pattern of contraction/relaxation. On the contrary, female preserved the pattern of contraction/relaxation increasing kinematic parameters. (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - May 22, 2019 Category: Molecular Biology Source Type: research

Three-dimensional encapsulation of adult mouse cardiomyocytes in hydrogels with tunable stiffness
Publication date: Available online 20 May 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Claudia Crocini, Cierra J. Walker, Kristi S. Anseth, Leslie A. LeinwandAbstractNumerous diseases, including those of the heart, are characterized by increased stiffness due to excessive deposition of extracellular matrix proteins. Cardiomyocytes continuously adapt their morphology and function to the mechanical changes of their microenvironment. Because traditional cell culture is conducted on substrates that are many orders of magnitude stiffer than any environment encountered by a cardiomyocyte in health or diseas...
Source: Progress in Biophysics and Molecular Biology - May 21, 2019 Category: Molecular Biology Source Type: research

Biophysics and the nonlinear dynamics instigated by a special hormone
Publication date: Available online 20 May 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Sana Javed, Ayesha Sohail, Anila Asif, Alessandro NutiniAbstractCalcitonin, a potent hypocalcemic hormone, plays a vital role in inhibiting osteoclastic activities and suppressing bone removal. The physiological characteristics of calcitonin have long been discussed, along a few recommending calcitonin as a vestigial hormone. The basis for this article is to discuss the role of low and high levels of calcitonin in normal and osteoprotic bone turnover. The effect of calcitonin on the receptor activator of nuclear fac...
Source: Progress in Biophysics and Molecular Biology - May 21, 2019 Category: Molecular Biology Source Type: research

They are not alone - Cell System and Bone Disease
Publication date: Available online 21 May 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Bin Tang (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - May 21, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: May 2019Source: Progress in Biophysics and Molecular Biology, Volume 143Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - May 16, 2019 Category: Molecular Biology Source Type: research

MicroRNAs as important regulators of the NLRP3 inflammasome
Publication date: Available online 15 May 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Parvin Zamani, Reza Kazemi Oskuee, Stephen L. Atkin, Jamshid Gholizadeh Navashenaq, Amirhossein SahebkarAbstractInflammasomes are a group of cytosolic multi-protein signaling complexes that regulate maturation of the interleukin (IL)-1 family cytokines IL-1β and IL-18 through activation of inflammatory caspase-1. The NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome is the best characterized and consists of several key components that are assembled and activated in response to different endog...
Source: Progress in Biophysics and Molecular Biology - May 15, 2019 Category: Molecular Biology Source Type: research

Effect of He-Ne laser irradiation on embryonic development in chicken eggs
This study investigated the influence of He-Ne laser irradiation at different doses during the developmental process of chicken embryos. Freshly fertilized chicken eggs were exposed duringthe first 48 hours post-laying to laser radiation at a wavelength of 632 nm with different laser doses (0.1, 0.2, 0.3, 1 and 2 mJ/cm2) for different times (20-400 secs) from a He-Ne laser. Following exposure, the eggs were incubated till the 11th day without laser radiation, when the. embryos were removed from the eggs and studied blind. Each of the exposed groups revealed some developmental anomalies compared with the respective sham–e...
Source: Progress in Biophysics and Molecular Biology - May 9, 2019 Category: Molecular Biology Source Type: research

Comprehensive analysis of the codon usage patterns of polyprotein of Zika virus
In this study, 90 ZIKV isolates were used for a comprehensive analysis on the codon usage patterns. The overall codon usage among ZIKV strains is similar and slightly biased. The value of effective number of codons (ENC) showed that the overall extent of codon usage bias in ZIKV is relatively low. Nucleotide analysis showed that the overall codon usage is biased toward A- and G-ending codons. The phylogenetic analysis indicated that their independent evolutionary origins from a common ancestor. The RSCU analysis showed that the codon usage pattern of ZIKV is more similar to that of Homo sapiens. Correlation analysis, Corre...
Source: Progress in Biophysics and Molecular Biology - May 3, 2019 Category: Molecular Biology Source Type: research

New insights into the physical processes that underpin cell division and the emergence of different cellular and multicellular structures
Publication date: Available online 25 April 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Philip Turner, Laurent Nottale, John Zhao, Edouard PesquetAbstractDespite decades of focused research, a detailed understanding of the fundamental physical processes that underpin biological systems (structures and processes) remains an open challenge. Within the present paper we report on biomimetic studies, which offer new insights into the process of cell division and the emergence of different cellular and multicellular structures.Experimental studies specifically investigated the impact of including different...
Source: Progress in Biophysics and Molecular Biology - April 26, 2019 Category: Molecular Biology Source Type: research

Physics meets medicine - At the heart of active matter
Publication date: Available online 10 April 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Marco Tarantola, Tim Meyer, Christoph F. Schmidt, Wolfram-Hubertus Zimmermann (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - April 25, 2019 Category: Molecular Biology Source Type: research

Molecular impacts of photobiomodulation on bone regeneration: A systematic review
Publication date: Available online 17 April 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Sepanta Hosseinpour, Reza Fekrazad, Praveen R. Arany, Qingsong YeAbstractPhotobiomodulation (PBM) encompasses a light application aimed to increase healing process, tissue regeneration, and reducing inflammation and pain. PBM is specifically aimed to modify the expression of cellular molecules; however, PBM impacts on cellular and molecular pathways especially in bone regenerative medicine have been investigated in scattered different studies. The purpose of the current study is to systematically review evidence o...
Source: Progress in Biophysics and Molecular Biology - April 25, 2019 Category: Molecular Biology Source Type: research