Biophysics and the nonlinear dynamics instigated by a special hormone

Publication date: Available online 20 May 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Sana Javed, Ayesha Sohail, Anila Asif, Alessandro NutiniAbstractCalcitonin, a potent hypocalcemic hormone, plays a vital role in inhibiting osteoclastic activities and suppressing bone removal. The physiological characteristics of calcitonin have long been discussed, along a few recommending calcitonin as a vestigial hormone. The basis for this article is to discuss the role of low and high levels of calcitonin in normal and osteoprotic bone turnover. The effect of calcitonin on the receptor activator of nuclear factor kappa-ligand and osteoclasts has been demonstrated using numerical simulations. This behavior recommends that treatment of osteoporosis via calcitonin does not provide the required upshots. For effectiveness calcitonin must be advised along with a combined therapy like aspirin which agrees with the experimental results available in the literature.
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research