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Beyond the Modern Synthesis: A Framework for a More Inclusive Biological Synthesis
Publication date: Available online 14 February 2020Source: Progress in Biophysics and Molecular BiologyAuthor(s): Peter A. CorningAbstractMany theorists in recent years have been calling for evolutionary biology to move beyond the Modern Synthesis – the paradigm that has long provided the theoretical backbone for the discipline. Terms like “postmodern synthesis,” “integrative synthesis,” and “extended evolutionary synthesis” have been invoked by various critics in connection with the many recent developments that pose deep challenges – even contradictions – to the traditional model and underscore the need...
Source: Progress in Biophysics and Molecular Biology - February 15, 2020 Category: Molecular Biology Source Type: research

Arrhythmia susceptibility in a rat model of acute atrial dilation
In conclusion, CV decrease is not sufficient to promote arrhythmias; enlargement of atrial surface is essential to create a substrate for acute reentry-based arrhythmias. (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - February 14, 2020 Category: Molecular Biology Source Type: research

T cell receptors, mechanosensors, catch bonds and immunotherapy
Publication date: Available online 30 January 2020Source: Progress in Biophysics and Molecular BiologyAuthor(s): Jia-huai WangAbstractT-cell based immunity is mediated through specific T cell receptor (TCR) recognition of a small antigenic peptide in complex with a host immune molecule, major compatibility complex (pMHC). The interaction of a TCR and its pMHC ligand is generally quite weak, degenerate and biophysically unfavorable. Yet, the resulting immune response is extremely effective, being both sensitive and specific.Recent observations indicate that the TCR is an anisotropic mechanosensor. The force sensed by TCR’...
Source: Progress in Biophysics and Molecular Biology - January 30, 2020 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: January 2020Source: Progress in Biophysics and Molecular Biology, Volume 150Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - January 17, 2020 Category: Molecular Biology Source Type: research

The role of DNA demethylation in induction of stem cells
Publication date: Available online 1 January 2020Source: Progress in Biophysics and Molecular BiologyAuthor(s): Mohammad H. Ghazimoradi, Shirin FarivarAbstractDNA methylation is an epigenetic factor, which plays important roles in embryo and many other diseases development. This factor determines gene expression, and when half of them have CpG islands, DNA methylation and its enzyme effectors have been under the vast studies. Whole genome DNA demethylation is a crucial step of embryogenesis and also cell fate determination in embryos. Therefore, demethylation agents were used as a tool for dedifferentiation and transdiffer...
Source: Progress in Biophysics and Molecular Biology - January 2, 2020 Category: Molecular Biology Source Type: research

Temporal irregularity quantification and mapping of optical action potentials using wave morphology similarity
ConclusionOWS mapping provides an effective measure of temporal regularity that can be applied to optical datasets to detect and quantify temporal alterations in action potential morphology. This methodology provides a new metric for arrhythmia inducibility and scoring in optical mapping datasets. (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - December 31, 2019 Category: Molecular Biology Source Type: research

Polygenic scores are an even bigger social hazard: Commentary on: Baverstock, K. (2019) polygenic scores: Are they a public health hazard? Progress in Biophysics and Molecular Biology. Available online 6 August 2019
Publication date: Available online 27 December 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ken Richardson (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - December 29, 2019 Category: Molecular Biology Source Type: research

Projective mechanisms subtending real world phenomena wipe away cause effect relationships
Publication date: Available online 12 December 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Arturo Tozzi, David PapoAbstractCausal relationships lie at the very core of scientific description of biophysical phenomena. Nevertheless, observable facts involving changes in system shape, dimension and symmetry may elude simple cause and effect inductive explanations. Here we argue that numerous physical and biological phenomena such as chaotic dynamics, symmetry breaking, long-range collisionless neural interactions, zero-valued energy singularities, and particle/wave duality can be accounted for in terms ...
Source: Progress in Biophysics and Molecular Biology - December 13, 2019 Category: Molecular Biology Source Type: research

Unique structural features of the Mycobacterium ribosome
Publication date: Available online 10 December 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ambuj Kumar Kushwaha, Shashi BhushanAbstractProtein synthesis in all the living cells is mediated by a large protein-RNA complex called the ribosome. These macromolecular complexes can range from 2.5 (prokaryotes) to 4.2 MDa(eukaryotes) in size and undergo various conformational transitions during protein synthesis to translate the genetic code into the nascent polypeptide chains. Recent advances in cryo-electron microscopy (cryo-EM) and image processing methods have provided numerous detailed structures of rib...
Source: Progress in Biophysics and Molecular Biology - December 10, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: December 2019Source: Progress in Biophysics and Molecular Biology, Volume 149Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - December 7, 2019 Category: Molecular Biology Source Type: research

Supervised and unsupervised algorithms for bioinformatics and data science
Publication date: Available online 6 December 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ayesha Sohail, Fatima ArifAbstractBioinformatics refers to an ever evolving huge field of research based on millions of algorithms, designated to several data banks. Such algorithms are either supervised or unsupervised. In this article, a detailed overview of the supervised and unsupervised techniques is presented with the aid of examples. The aim of this article is to provide the readers with the basic understanding of the state of the art models, which are key ingredients of explainable machine learning in th...
Source: Progress in Biophysics and Molecular Biology - December 7, 2019 Category: Molecular Biology Source Type: research

Current density as routine parameter for description of ionic membrane current: is it always the best option?
Publication date: Available online 30 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Roman Kula, Markéta Bébarová, Peter Matejovič, Jiří Šimurda, Michal PásekAbstractThe current density (J) is a parameter routinely used to characterize individual ionic membrane currents. Its evaluation is based on the presumption that the magnitude of whole-cell ionic membrane current (I) is directly proportional to the cell membrane capacitance (C), i.e. I positively and strongly correlates with C and the regression line describing I–C relation intersects the y-axis close to the origin of coordinates...
Source: Progress in Biophysics and Molecular Biology - December 1, 2019 Category: Molecular Biology Source Type: research

Possible traces of resonance signaling in the genome
Publication date: Available online 29 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ivan Savelyev, Max Myakishev-RempelAbstractAlthough theories regarding the role of sequence-specific DNA resonance in biology have abounded for over 40 years, the published evidence for it is lacking. Here, the authors reasoned that for sustained resonance signaling, the number of oscillating DNA sequences per genome should be exceptionally high and that, therefore, genomic repeats of various sizes are good candidates for serving as resonators. Moreover, it was suggested that for the two DNA sequences to resona...
Source: Progress in Biophysics and Molecular Biology - November 30, 2019 Category: Molecular Biology Source Type: research

Non-coding RNAs regulate autophagy process via influencing the expression of associated protein
Publication date: Available online 28 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Yunyi Zhao, Ze Wang, Wenhui Zhang, Linbo ZhangAbstractAutophagy is a tightly-regulated multi-step process involving the lysosomal degradation of proteins and cytoplasmic organelles. Central to this process is the formation of the autophagosome, a double membrane-bound vesicle, which is fuse with lysosomes or endosomes, and then deliver its cytoplasmic cargo to the lysosomes. Here, we summarize the recent process of autophagy, focusing on protein molecules, their complexes, and its essential roles of autophagy i...
Source: Progress in Biophysics and Molecular Biology - November 28, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: November 2019Source: Progress in Biophysics and Molecular Biology, Volume 148Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - November 28, 2019 Category: Molecular Biology Source Type: research