Genistein inhibits A β25–35‐induced SH‐SY5Y cell damage by modulating the expression of apoptosis‐related proteins and Ca2+ influx through ionotropic glutamate receptors
In this study, we investigated the protective effects of genistein against SH ‐SY5Y cell damage induced by β‐amyloid 25–35 peptide (Aβ25 –35) and the underlying mechanisms. A β‐induced neuronal death, apoptosis, glutamate receptor subunit expression, Ca2+ ion concentration, amino acid transmitter concentration, and apoptosis ‐related factor expression were evaluated to determine the effects of genistein on Aβ‐induced neuronal death and apoptosis. The results showed that genistein increased the survival of SH‐SY5Y cells and decreased the level of apoptosis induced by Aβ25 –35. In addition, genistein r...
Source: Phytotherapy Research - November 19, 2018 Category: Biochemistry Authors: Hui ‐nan Xu,
Li‐xia Li,
Yu‐xiang Wang,
Hong‐gang Wang,
Di An,
Bin Heng,
Yan‐qiang Liu Tags: RESEARCH ARTICLE Source Type: research
Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double ‐blind, placebo‐controlled clinical trial of efficacy and safety
This study was carried out to assess the efficacy ofA. citriodora in patients with insomnia. One hundred patients were randomly divided into two groups ofA. citriodora (total essential oil 1.66 mg/10 ml and total amount of flavonoid in terms of quercetin 3.22 mg/10 ml of the syrup) and placebo. They were advised to use 10 cc of the syrups; an hour before the bedtime for a period of 4 weeks. Participants were assessed using Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) questionnaires at the baseline and then 2 and 4 weeks after the enrollment. Mean scores of global PSQI and its four com...
Source: Phytotherapy Research - November 19, 2018 Category: Biochemistry Authors: Farshid Afrasiabian,
Mehran Mirabzadeh Ardakani,
Khaled Rahmani,
Nammam Ali Azadi,
Zahra Banafsheh Alemohammad,
Reza Bidaki,
Mehrdad Karimi,
Majid Emtiazy,
Mohammad Hashem Hashempur Tags: RESEARCH ARTICLE Source Type: research
Regulation of faecal biomarkers in inflammatory bowel disease patients treated with oral mastiha (Pistacia lentiscus) supplement: A double ‐blind and placebo‐controlled randomised trial
There is a keen research upon the effects of nutraceuticals on inflammatory bowel disease. The purpose of this study was to explore the effect of mastiha supplement, rich in bioactive nutraceuticals, in active inflammatory bowel disease. This is a randomised, double ‐blind, placebo‐controlled clinical trial. Α total of 60 inflammatory bowel disease patients were enrolled and randomly allocated to mastiha (2.8 g/day) or placebo groups for 3 months adjunct to stable medical treatment. Medical and dietary history, Inflammatory Bowel Disease Questionnaire (I BDQ), Harvey‐Bradshaw index, partial Mayo score, biochemical...
Source: Phytotherapy Research - November 18, 2018 Category: Biochemistry Authors: Efstathia Papada,
Aristea Gioxari,
Charalampia Amerikanou,
Alastair Forbes,
Chara Tzavara,
Ilias Smyrnioudis,
Andriana C. Kaliora Tags: RESEARCH ARTICLE Source Type: research
Randomized, double ‐blind, placebo‐controlled phase II trial of nanocurcumin in prostate cancer patients undergoing radiotherapy
In conclusion, this RCT was underpowered to indicate the efficacy of nanocurcumin in this clinical setti ng but could provide a considerable new translational insight to bridge the gap between the laboratory and clinical practice. (Source: Phytotherapy Research)
Source: Phytotherapy Research - November 14, 2018 Category: Biochemistry Authors: Afshin Saadipoor,
Abolfazl Razzaghdoust,
Nasser Simforoosh,
Arash Mahdavi,
Mohsen Bakhshandeh,
Maryam Moghadam,
Hamid Abdollahi,
Bahram Mofid Tags: RESEARCH ARTICLE Source Type: research
Calycosin attenuates MPTP ‐induced Parkinson's disease by suppressing the activation of TLR/NF‐κB and MAPK pathways
This study aims to explore whether calycosin can alleviate PD symptoms and the underlying mechanisms. PD was induced in mice by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydr opyridine (MPTP) injection, and calycosin was given intracerebroventricularly to these mice. A cell model of nerve inflammation was established by BV2 microglia cells injected with lipopolysaccharide (LPS). The motor states were evaluated by stepping, whisker, and cylinder experiments. The states of dopaminergic neurons and microglia were detected by immunostainning of tyrosine hydroxylase and cluster of differentiation molecule 11b (CD11b). The expres...
Source: Phytotherapy Research - November 12, 2018 Category: Biochemistry Authors: Jing Yang,
Mengmeng Jia,
Xiaojian Zhang,
Peile Wang Tags: RESEARCH ARTICLE Source Type: research
Isobavachalcone attenuates myotube atrophy induced by TNF ‐α through muscle atrophy F‐box signaling and the nuclear factor erythroid 2‐related factor 2 cascade
Skeletal muscle atrophy is a condition characterized by damaged muscle fibers and reduced numbers of muscle cells due to various causes. Muscle atrophy is associated with chronic diseases, such as heart failure, diabetes, and aging ‐related diseases. Isobavachalcone (IBC) is a flavonoid found in various foods and natural products, and studies have investigated its diverse effects, including its neuroprotective and anticancer effects. However, no studies have evaluated the effects of IBC on muscle atrophy. Thus, in this study , we assessed the effects of IBC on prevention of muscle atrophy. To evaluate the preventive effe...
Source: Phytotherapy Research - November 12, 2018 Category: Biochemistry Authors: Jinyoung Hur,
Mina Kim,
Sang Yoon Choi,
YoungJin Jang,
Tae Youl Ha Tags: RESEARCH ARTICLE Source Type: research
Herbal medicine in oral lichen planus
Oral lichen planus (OLP) is a common chronic inflammatory and T cell ‐mediated autoimmune disease in which the oral mucosa, tongue, and gingiva are involved. Different treatments have been suggested to reduce the symptoms of this disease. Currently, a common treatment for OLP is the use of corticosteroids as the gold standard, although they have considerable side e ffects. The chronicity of the disease needs the long‐term use of these drugs with ensuing side effects. Therefore, various studies have been done to find an alternative and effective treatment. The use of herbal medicine as an alternative therapy with antiox...
Source: Phytotherapy Research - November 12, 2018 Category: Biochemistry Authors: Atefeh Ghahremanlo,
Nadia Boroumand,
Kiarash Ghazvini,
Seyed Isaac Hashemy Tags: REVIEW Source Type: research
Effect of puerarin on melanogenesis in human melanocytes and vitiligo mouse models and the underlying mechanism
In this study, we found that after treating with puerarin at various concentrations of 40 μmol/L, the melanin content of human melanocytes increased significantly and the apparent level of protein and the RNA levels of MITF, tyrosinase (TYR), and tyrosinase‐related protein 1 (TRP‐1) w ere also increased. Further, puerarin was shown to inhibit phosphorylation and activation of extracellular signal‐regulated kinase 1 and 2 (ERK1/2) without significantly affecting p38 and c‐Jun N‐terminal kinase phosphorylation. These results demonstrated that puerarin stimulated melanogenesis in human melanocytes via inhibition o...
Source: Phytotherapy Research - November 12, 2018 Category: Biochemistry Authors: Xiaoxia Ding,
Enci Mei,
Murong Hu,
Chaofeng Zhou,
Xiaobin Li,
Lei Cai,
Zhiming Li Tags: RESEARCH ARTICLE Source Type: research
Calycosin attenuates MPTP ‐induced Parkinson's disease by suppressing the activation of TLR/NF‐κB and MAPK pathways
This study aims to explore whether calycosin can alleviate PD symptoms and the underlying mechanisms. PD was induced in mice by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydr opyridine (MPTP) injection, and calycosin was given intracerebroventricularly to these mice. A cell model of nerve inflammation was established by BV2 microglia cells injected with lipopolysaccharide (LPS). The motor states were evaluated by stepping, whisker, and cylinder experiments. The states of dopaminergic neurons and microglia were detected by immunostainning of tyrosine hydroxylase and cluster of differentiation molecule 11b (CD11b). The expres...
Source: Phytotherapy Research - November 12, 2018 Category: Biochemistry Authors: Jing Yang,
Mengmeng Jia,
Xiaojian Zhang,
Peile Wang Tags: RESEARCH ARTICLE Source Type: research
Isobavachalcone attenuates myotube atrophy induced by TNF ‐α through muscle atrophy F‐box signaling and the nuclear factor erythroid 2‐related factor 2 cascade
Skeletal muscle atrophy is a condition characterized by damaged muscle fibers and reduced numbers of muscle cells due to various causes. Muscle atrophy is associated with chronic diseases, such as heart failure, diabetes, and aging ‐related diseases. Isobavachalcone (IBC) is a flavonoid found in various foods and natural products, and studies have investigated its diverse effects, including its neuroprotective and anticancer effects. However, no studies have evaluated the effects of IBC on muscle atrophy. Thus, in this study , we assessed the effects of IBC on prevention of muscle atrophy. To evaluate the preventive effe...
Source: Phytotherapy Research - November 12, 2018 Category: Biochemistry Authors: Jinyoung Hur,
Mina Kim,
Sang Yoon Choi,
YoungJin Jang,
Tae Youl Ha Tags: RESEARCH ARTICLE Source Type: research
Herbal medicine in oral lichen planus
Oral lichen planus (OLP) is a common chronic inflammatory and T cell ‐mediated autoimmune disease in which the oral mucosa, tongue, and gingiva are involved. Different treatments have been suggested to reduce the symptoms of this disease. Currently, a common treatment for OLP is the use of corticosteroids as the gold standard, although they have considerable side e ffects. The chronicity of the disease needs the long‐term use of these drugs with ensuing side effects. Therefore, various studies have been done to find an alternative and effective treatment. The use of herbal medicine as an alternative therapy with antiox...
Source: Phytotherapy Research - November 12, 2018 Category: Biochemistry Authors: Atefeh Ghahremanlo,
Nadia Boroumand,
Kiarash Ghazvini,
Seyed Isaac Hashemy Tags: REVIEW Source Type: research
Effect of puerarin on melanogenesis in human melanocytes and vitiligo mouse models and the underlying mechanism
In this study, we found that after treating with puerarin at various concentrations of 40 μmol/L, the melanin content of human melanocytes increased significantly and the apparent level of protein and the RNA levels of MITF, tyrosinase (TYR), and tyrosinase‐related protein 1 (TRP‐1) w ere also increased. Further, puerarin was shown to inhibit phosphorylation and activation of extracellular signal‐regulated kinase 1 and 2 (ERK1/2) without significantly affecting p38 and c‐Jun N‐terminal kinase phosphorylation. These results demonstrated that puerarin stimulated melanogenesis in human melanocytes via inhibition o...
Source: Phytotherapy Research - November 12, 2018 Category: Biochemistry Authors: Xiaoxia Ding,
Enci Mei,
Murong Hu,
Chaofeng Zhou,
Xiaobin Li,
Lei Cai,
Zhiming Li Tags: RESEARCH ARTICLE Source Type: research
Enzymes inhibitors from natural sources with antidiabetic activity: A review
Many medicinal plants products and groups of isolated phytochemicals have shown promising effects as enzyme inhibitors with different mechanism important for new antidiabetic drug design. The most involved mechanisms are inhibition of intestinal α‐glucosidase and amylase; lens aldose reductase; oxidative stress protection; inhibition of formation of AGEs; inhibition ALR; alters enzyme activity of hexokinases and glucose‐6‐phosphate; synthesize and release of insulin; postprandial hyperglycemia inhibition; stimulation of GLUT‐4; and decrease activity of G6P. Natural products have been extensively investigated for a...
Source: Phytotherapy Research - November 11, 2018 Category: Biochemistry Authors: Fiaz Alam,
Zainab Shafique,
Sayyeda Tayyeba Amjad,
Mohammad Hassham Hassan Bin Asad Tags: REVIEW Source Type: research
