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Strain differences in muscarinic cholinergic receptor antagonism of fat intake and acquisition and expression of fat-conditioned flavor preferences in male BALB/c, C57BL/6 and SWR mice
Publication date: Available online 5 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Ben Iskhakov, Petra Dohnalova, Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Nicole Locurto, Nicole Franz, Gabriela Fazilov, Merna Shenouda, Richard J. BodnarAbstractMurine strain differences occur for both intakes of and preferences for sugars and fats. Previous studies demonstrated that the muscarinic cholinergic receptor antagonist, scopolamine (SCOP) more potently reduced sucrose and saccharin intakes in inbred C57BL/6 and BALB/c than SWR mice, sucrose-conditioned flavor preferences...
Source: Pharmacology Biochemistry and Behavior - October 6, 2019 Category: Biochemistry Source Type: research

Prenatal melamine exposure impairs cognitive flexibility and hippocampal synaptic plasticity in adolescent and adult female rats
Publication date: Available online 10 September 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Lei An, Jia Li, Le Luo, Peidong Huang, Peidong Liu, Chunzhi Tang, Wei SunAbstractPrenatal melamine exposure (PME) affects spatial cognition in adolescent male rats and impairs synaptic functions. Strikingly, these effects can persist into adulthood. The current experiments examined whether PME-induced behavioral defects would be observed in female offspring, and how these effects varied with age (adolescent and adult). After female rats were exposed to melamine through their entire gestational period (GD), their spa...
Source: Pharmacology Biochemistry and Behavior - September 10, 2019 Category: Biochemistry Source Type: research

Caffeine modulates voluntary alcohol intake in mice depending on the access conditions: Involvement of adenosine receptors and the role of individual differences
Publication date: Available online 6 September 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): N. SanMiguel, L. López-Cruz, C.E. Müller, J.D. Salaemone, M. CorreaAbstractCaffeine is the most consumed psychoactive stimulant and the main active ingredient of energy drinks. Epidemiology studies have shown a positive correlation between the consumption of energy drinks and that of ethanol. The popular belief is that caffeine antagonizes the intoxicating effects of alcohol. Both drugs act on the adenosine system but have opposite effects. Caffeine is a methylxanthine that acts as a nonselective adenosine receptor...
Source: Pharmacology Biochemistry and Behavior - September 6, 2019 Category: Biochemistry Source Type: research

Cholinergic system and exploratory behavior are changed after weekly-binge ethanol exposure in zebrafish
Publication date: Available online 6 September 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Henrique Teza Bernardo, Jotele Fontana Agostini, Helena Cristina Zuehl Dal Toé, Karine Medeiros Vieira, Samira Leila Baldin, Patrícia Fernanda Schuck, Carolina Uribe-Cruz, Larisse Longo, Themis Reverbel da Silveira, Denis Broock Rosemberg, Eduardo Pacheco RicoAbstractBinge drinking is characterized by excessive alcohol consumption in a short period of time and is associated with a poor quality of life. Zebrafish are commonly used to investigate neurochemical, behavioral, and genetic parameters associated with ethan...
Source: Pharmacology Biochemistry and Behavior - September 6, 2019 Category: Biochemistry Source Type: research

P2Y receptors in neuropathic pain
Publication date: Available online 5 September 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Xinge Zhang, Guilin LiAbstractThis review summarizes and evaluates the relationship between neuropathic pain and P2Y receptors from inception to 2019. Purinergic receptors have been well studied in recent years using various molecular biological methods. The main research objective of this review is to determine the association of P2Y1, P2Y2, P2Y6, P2Y12 and P2Y13 receptors with neuropathic pain. This review includes the most comprehensive subtypes of P2Y that related to neuropathic pain and the current therapeutic m...
Source: Pharmacology Biochemistry and Behavior - September 5, 2019 Category: Biochemistry Source Type: research