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Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice
Publication date: Available online 29 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Hidaka Haga, Ryo Yamada, Hisanao Izumi, Yasuharu Shinoda, Ichiro Kawahata, Hiroyuki Miyachi, Kohji Fukunaga (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 29, 2020 Category: Biochemistry Source Type: research

The dosage-dependent effects of cevimeline in preventing olanzapine-induced metabolic side-effects in female rats
Publication date: Available online 26 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Jiamei Lian, Chao Deng (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 27, 2020 Category: Biochemistry Source Type: research

Editorial Board
Publication date: March 2020Source: Pharmacology Biochemistry and Behavior, Volume 190Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 27, 2020 Category: Biochemistry Source Type: research

Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior
Publication date: Available online 24 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Christine H. Lee, Olivier George, Adam KimbroughAbstractCaffeine is the most widely consumed psychoactive substance in the world. However, there is controversy about whether becoming addicted to caffeine is possible and a lack of well-established animal models to examine caffeine consumption. The present study sought to establish a model of caffeine consumption in Wistar rats, identify different rat populations of caffeine preference, and determine whether extended voluntary caffeine consumption produces compulsive-l...
Source: Pharmacology Biochemistry and Behavior - February 24, 2020 Category: Biochemistry Source Type: research

The long-term but not short-term use of benzodiazepine impairs motoric function and upregulates amyloid β in part through the suppression of translocator protein
Publication date: Available online 24 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Marianna E. Jung, Daniel B. Metzger, James HallAbstractMany elderly American women use CNS depressant benzodiazepine (BZD) to ameliorate anxiety or insomnia. However, the chronic use of BZD (cBZD) is prevalent, causing adverse effects of BZD that include movement deficit. We previously reported that cBZD upregulates neurotoxic amyloid β42 (Aβ42) and downregulates neuroprotective translocator protein (TSPO) in the cerebellum, the brain area of movement and balance. The aim of the current study is two-fold: 1) to det...
Source: Pharmacology Biochemistry and Behavior - February 24, 2020 Category: Biochemistry Source Type: research

Analgesic treatment with buprenorphine should be adapted to the mouse strain
Publication date: Available online 20 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Juliane Rudeck, Silvia Vogl, Céline Heinl, Matthias Steinfath, Sebastian Fritzw.er, Andrea Kliewer, Stefan Schulz, Gilbert Schönfelder, Bettina BertAbstractBuprenorphine is a commonly used opioid to treat moderate to severe pain in mice. Although strain differences regarding basal pain sensitivity and the analgesic effect of other opioids have been described for mice, the data for buprenorphine is incomplete. Hence, we investigated basal pain sensitivity and the analgesic effect of buprenorphine (0.42, 4.0 mg·kg...
Source: Pharmacology Biochemistry and Behavior - February 21, 2020 Category: Biochemistry Source Type: research

(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression
Publication date: Available online 20 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Rei Yokoyama, Momoko Higuchi, Wataru Tanabe, Shinji Tsukada, Megumi Naito, Takumi Yamaguchi, Lu Chen, Atsushi Kasai, Kaoru Seiriki, Takanobu Nakazawa, Shinsaku Nakagawa, Kenji Hashimoto, Hitoshi Hashimoto, Yukio AgoAbstractClinical and preclinical studies have shown that the N-methyl-d-aspartate receptor antagonist ketamine exerts rapid and long-lasting antidepressant effects. Although ketamine metabolites might also have potential antidepressant properties, controversial results have been reported for (2R,6R)-hydrox...
Source: Pharmacology Biochemistry and Behavior - February 21, 2020 Category: Biochemistry Source Type: research

Age-dependent effects of repeated methamphetamine exposure on locomotor activity and attentional function in rats
Publication date: Available online 21 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Azadeh Nazari, Cristian Perez-Fernandez, Pilar Flores, Margarita Moreno, Fernando Sánchez-SantedAbstractMany adolescents use amphetamines which are the second most common abused illegal drugs. Methamphetamine (Meth), as a potent amphetamine affects attentional functions. However, the most significant factor for susceptibility to Meth is the age of exposure, most studies have examined the effects of Meth after early adolescence stage. The present experiment was aimed to investigate some possible short- and long-term ...
Source: Pharmacology Biochemistry and Behavior - February 21, 2020 Category: Biochemistry Source Type: research

Effects of NBI-98782, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, on neurotransmitter efflux and phencyclidine-induced locomotor activity: Relevance to tardive dyskinesia and antipsychotic action
Publication date: Available online 18 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Mei Huang, Wenqi He, Lakshmi Rajagopal, Andrea Kudwa, Dimitri E. Grigoriadis, Herbert Y. MeltzerAbstractValbenazine, a vesicular monoamine transporter 2 (VMAT2, SLC18A2) inhibitor, is a newly approved treatment for tardive dyskinesia. VMAT2 is present in the membrane of secretory vesicles and transports dopamine (DA), norepinephrine (NE), serotonin (5-HT), histamine, glutamate (Glu), and GABA into vesicles for presynaptic release. We utilized microdialysis in awake, freely moving mice to determine the effect of NBI-9...
Source: Pharmacology Biochemistry and Behavior - February 20, 2020 Category: Biochemistry Source Type: research

Differential effects of lithium isotopes in a ketamine-induced hyperactivity model of mania
Publication date: Available online 19 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Aaron Ettenberg, Kathy Ayala, Jacob T. Krug, Lisette Collins, Matthew S. Mayes, Matthew P.A. FisherAbstractSub-anesthetic doses of ketamine produce an increase in rodent ambulation that is attenuated by co-administration of naturally-occurring lithium (LiN), the drug most commonly employed in the treatment of bipolar illness. As a consequence, ketamine-induced hyperactivity has been proposed as an animal model of manic behavior. The current study employed a modified version of this model to compare the potency of LiN...
Source: Pharmacology Biochemistry and Behavior - February 20, 2020 Category: Biochemistry Source Type: research

Environmental enrichment reduces food seeking and taking in rats: A review
Publication date: Available online 19 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Jeffrey W. Grimm, Frances SauterAbstractEnvironmental enrichment (EE) for rodents is generally defined as providing subjects with an environment enhanced with access to conspecifics, novel and tactile stimuli, and in many preparations, more space. EE exposure, in particular as an “intervention” in adult rodents, decreases food and drug seeking and taking. This review focuses on the reduction of sucrose seeking and taking in rats assessed in operant-based procedures. The operant-based model provides a means to eva...
Source: Pharmacology Biochemistry and Behavior - February 20, 2020 Category: Biochemistry Source Type: research

Synthetic psychoactive cathinones: Hypothermia and reduced lethality compared to methamphetamine and methylenedioxymethamphetamine
ConclusionsThese data indicate that, under the conditions studied here: (1) SPCs exhibit less lethality than MA and MDMA; (2) SPCs impair thermoregulation; (3) effects of SPCs on temperature appear to be independent of effects on lethality. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 13, 2020 Category: Biochemistry Source Type: research

A historical review of antidepressant effects of ketamine and its enantiomers
Publication date: Available online 5 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Yan Wei, Lijia Chang, Kenji HashimotoAbstractThe robust antidepressant effects of (R,S)-ketamine are among the most important discoveries in mood research over the last half century. Off-label use of (R,S)-ketamine, which is an equal mixture of (R)-ketamine and (S)-ketamine, has become especially popular in the United States (US) for treatment-resistant depression. On March 5, 2019, the US Food and Drug Administration approved an (S)-ketamine nasal spray for use in treatment-resistant depression, though its use has be...
Source: Pharmacology Biochemistry and Behavior - February 6, 2020 Category: Biochemistry Source Type: research

Editorial Board
Publication date: February 2020Source: Pharmacology Biochemistry and Behavior, Volume 189Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 30, 2020 Category: Biochemistry Source Type: research

Serotonin 5-HT1A and 5-HT1B receptors co-mediate the RU 24969-induced locomotor activity of male and female preweanling rats
Publication date: February 2020Source: Pharmacology Biochemistry and Behavior, Volume 189Author(s): Sanders A. McDougall, Jasmine A.M. Robinson, Esperanza Larios Ramirez, Henry A. DiazAbstractThe serotonin (5-HT) 1A/1B agonist RU 24969 robustly increases the locomotor activity of adult male rats and mice; however, studies using selective antagonists alternately report that 5-HT1A, 5-HT1B, or both receptor types mediate RU 24969's locomotor activating effects. The purpose of the present study was to extend these past findings by administering a selective 5-HT1 agonist and/or antagonists to male and female preweanling rats. ...
Source: Pharmacology Biochemistry and Behavior - January 26, 2020 Category: Biochemistry Source Type: research