Stunted Growth. Proceedings of the 23rd Aschauer Soiree, Held at Aschauhof, Germany, November 7th 2015.
Authors: Hermanussen M, Ipsen J, Mumm R, Assmann C, Quitmann J, Gomula A, Lehmann A, Jasch I, Tassenaar V, Bogin B, Satake T, Scheffler C, Núñez J, Godina E, Hardeland R, Boldsen J, El-Shabrawi M, Elhusseini M, Barbu CG, Pop R, Söderhäll J, Merker A, Swanson J, Groth D
Abstract
Twenty-four scientists met at Aschauhof, Altenhof, Germany, to discuss the associations between child growth and development, and nutrition, health, environment and psychology. Meta-analyses of body height, height variability and household inequality, in historic and modern growth studies published since 1794, highlighting the e...
Source: Pediatric Endocrinology Reviews - July 29, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Jens Sandahl Christiansen, DMSci, FRCPI (1948-2015).
Authors: Jørgensen JO, Kopchick JJ, Bengtsson BÅ, Kappelgaard AM
PMID: 27116843 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - April 29, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Contingent Screening for Small by Weight for Gestational Age Neonates.
Authors: Frick AP, Nicolaides KH, Poon LC
Abstract
Effective screening for small for gestational age neonates (SGA), in the absence of preeclampsia, can be accomplished using a contingent screening method. The basis for the contingent model is a combined assessment at 19-24 weeks gestation to stratify patients according to their risk. We can then identify prenatally over 90% of SGA neonates for a false positive rate of 10%.
PMID: 27116844 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - April 29, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Changing and Unchanging Perspectives regarding Intersex in the Last Half Century: Topics Presented in the Lawson Wilkins Lecture* at the 2015 Pediatric Endocrine Society Meeting.
Authors: Lee PA, Houk CP
Abstract
The understanding, care and treatment of patients born with intersex or disorders of sex development conditions has evolved considerably over the last five decades. Regarding those who require evaluation before gender assignment is made, each "generation" of approach has been based upon and reflects the contemporary biological, social and psychological understanding. The most recent generation needs to consider the dramatically changed societal viewpoints regarding the acceptance and expansion beyond a binary perception of sexuality. This together with advances in genetic ...
Source: Pediatric Endocrinology Reviews - April 29, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Evidence-Based Management of Patients with 45,X/46,XY Gonadal Dysgenesis and Male Sex Assignment: from Infancy to Adulthood.
Authors: Colindres JV, Axelrad M, McCullough L, Smith EO, Huang GO, Tu DD, Bercaw-Pratt JL, Cheni MJ, Mendiratta M, Gunn S, Sutton R, Macias C, Karaviti LP
Abstract
45,X/46,XY gonadal dysgenesis is a disorder of sexual differentiation with a wide clinical presentation, ranging from Turner-like females to individuals with genital ambiguity to azoospermic but otherwise normal-appearing males. Hence, patients can be assigned female or male sex. Female patients are managed according to the Turner Syndrome Guidelines, whereas males are managed on a case-by-case basis. Male patients present with multiple medical...
Source: Pediatric Endocrinology Reviews - April 29, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Salivary Biomarkers in Pediatric Metabolic Disease Research.
Authors: Hartman ML, Goodson JM, Barake R, Alsmadi O, Al-Mutawa S, Ariga J, Soparkar P, Behbehani J, Behbehani K
Abstract
The increasing prevalence of childhood obesity and obesity-related metabolic disorders is now considered a global pandemic. The main goal of the pediatric obesity research community is to identify children who are at risk of becoming obese before their body mass index rises above age norms. To do so, we must identify biomarkers of metabolic health and immunometabolism that can be used for large-scale screening and diagnosis initiatives among at-risk children. Because blood sampling is o...
Source: Pediatric Endocrinology Reviews - April 29, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Thyroid Hemiagenesis from Childhood to Adulthood: Review of Literature and Personal Experience.
Authors: De Sanctis V, Soliman AT, Di Maio S, Elsedfy H, Soliman NA, Elalaily R
Abstract
Thyroid hemiagenesis (TH) is a rare congenital abnormality of the thyroid gland, characterised by the absence of one lobe. The true prevalence of this congenital abnormality is not known because the absence of one thyroid lobe usually does not cause clinical symptoms by itself. Between 1970 and 2010, 329 cases of TH have been reported. It is interesting to note that most cases have an agenesis of the left lobe (80% of cases) followed by the isthmus (44-50% of cases). Although the female to male ratio was 1:1.4 in 24,03...
Source: Pediatric Endocrinology Reviews - April 29, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Insulin-Like Growth Factor-I is a Marker for the Nutritional State.
Authors: Hawkes CP, Grimberg A
Abstract
Measurement of the serum concentration of insulin-like growth factor-I (IGF-l) is generally used as a screening investigation for disorders of the growth hormone (GH)/IGF-I axis in children and adolescents with short stature. IGF-I concentration is sensitive to short-term and chronic alterations in the nutritional state, and the interpretation of IGF-I measurements requires knowledge of the child's nutritional status. In this review, we summarize the effects of nutrition on the GH/IGF-I axis, and review the clinical implications of these interactions throughout child...
Source: Pediatric Endocrinology Reviews - February 8, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Primary Dysmenorrhea in Adolescents: Prevalence, Impact and Recent Knowledge.
CONCLUSIONS: Dysmenorrhea is an important health problem for adolescents, school and occupational as well as practitioners that adversely affects the daily activities and quality of life for adolescent women. The accurate prevalence of dysmenorrhea is difficult to establish due to the variety of diagnostic criteria and the subjective nature of the symptoms. In adolescents, moderate to severe dysmenorrhea that affects lifestyle and does not respond to medical treatment requires professional attention and proper diagnosis of possible underlying pelvic disease. Therefore, adolescent care providers should be more knowledgeable...
Source: Pediatric Endocrinology Reviews - February 8, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Insulin-Like Growth Factor Binding Proteins--an Update.
Authors: Bach LA
Abstract
The insulin-like growth factor (IGF) system is essential for normal growth and development, and its perturbation is implicated in a number of diseases. IGF activity is finely regulated by a family of six high-affinity IGF binding proteins (IGFBPs). 1GFBPs usually inhibit IGF actions but may enhance them under certain conditions. Additionally, IGFBPs bind non-IGF ligands in the extracellular space, cell membrane, cytoplasm and nucleus, thereby modulating cell proliferation, survival and migration in an IGF-independent manner. IGFBP activity is regulated by transcriptional mechanism...
Source: Pediatric Endocrinology Reviews - February 8, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
The Effects of Electromagnetic Field on the Endocrine System in Children and Adolescents.
Authors: Sangün Ö, Dündar B, Çömlekçi S, Büyükgebiz A
Abstract
Children are exposed to various kind of non-ionizan radiation in their daily life involuntarily. The potential sensitivity of developing organism to the effects of radiofrequency (RF) signals, the higher estimated specific absorption rate (SAR) values of children and greater lifetime cumulative risk raised the scientific interest for children's vulnerability to electromagnetic fields (EMFs). In modern societies, children are being exposed to EMFs in very early ages. There are many researches in scientific literature investigating the al...
Source: Pediatric Endocrinology Reviews - February 8, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Nutrimetabolomics and Adipocitokines in the "Great Obstetrical Syndromes".
Authors: De Magistris A, Marincola FC, Fanos V, Dessi A
Abstract
In neonatal medicine, nutritional research is focusing more and more on thrifty phenotype effects, in order to understand and prevent the development of long-term diseases. lschemic placental disease which brings together Gestational diabete, Preeclamptic Toxemia, and Intrauterine Growth Restriction, the "Great Obstetrical Syndromes" (GOS), originates from sugar.and lipid metabolism. Adipokines and metabolomics can be valuable tools for the diagnosis of obstetrical syndromes and addressing nutrition. Inappropriate nutrition, even in the first...
Source: Pediatric Endocrinology Reviews - February 8, 2016 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Message from the Editors.
Authors: Laron Z, Geffner ME, Tanaka T
PMID: 26540756 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - November 18, 2015 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Hans Helge, MD, PhD (1935-2015).
Authors: Helge T
PMID: 26540757 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - November 18, 2015 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Lawson Wilkins, MD, 1894-1963: A Founding Father of Pediatric Endocrinology.
Authors: Fuqua JS, Lee PA
PMID: 26540758 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - November 18, 2015 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
