Growth Hormone Therapy and Brain Tumors.
Authors: Teramoto A
Abstract
As one of the projects of the Adverse Events Study Group of the Foundation for Growth Science in Japan, the literatures on the recurrence and / or regrowth or new formation of brain tumors in patients treated with growth hormone (GH) were reviewed. Since the tumor volume of the sellar lesion can be accurately evaluated only by magnetic resonance imaging (MRI), the related literatures published after 1990 were retrieved by searching under keywords, such as GH, replacement therapy, brain tumor, recurrence, tumor formation, etc. It is undeniable that GH therapy may result in tumor...
Source: Pediatric Endocrinology Reviews - May 19, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Growth Hormone Treatment and Adverse Events.
Authors: Nishi Y, Tanaka T
Abstract
We compiled the major adverse events included in the Annual Research Reports of the Foundation for Growth Research published in and after 2000. We conducted a review of approximately 32,000 patients treated with growth hormone (GH) who subsequently developed leukemia and who were registered with the Foundation for Growth Research (from 1975 to December 31 1997). We performed a literature review and found that GH therapy was not associated with leukemia onset in patients with no risk factors for leukemia. We also reported the onset of diabetes mellitus (DM), scoliosis, an...
Source: Pediatric Endocrinology Reviews - May 19, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Revision of the Growth References for Japanese Girls with Turner Syndrome.
Authors: Isojima T
PMID: 28516753 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - May 19, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Adult Height in Patients with Turner Syndrome and Association with Lifestyle-related Diseases after Human Growth Hormone Treatment in Japan.
Authors: Hanew K, Tanaka T
PMID: 28516754 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - May 19, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Iodine and Thyroid Function: A Historical Review of Goiter and the Current Iodine Status in Japan.
Authors: Fuse Y
PMID: 28516755 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - May 19, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
In Memoriam: Juan Jorge Heinrich, MD, PhD (1937-2016).
Authors: Bergadá I, Rey R
PMID: 28508596 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - May 18, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
In Memoriam: Melvin M. Grumbach, MD, (1925-2016) Pediatric Endocrinologist, Scientist, Educator, Leader.
Authors: Miller WL
PMID: 28508597 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - May 18, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
For Debate: Should We Worry about Hematospermia in Adolescents and Young Men? A Report of Six Cases and Review of the Literature.
Authors: De Sanctis V, Zargooshi J, Marsciani A, Soliman AT, Elsedfy H, Soliman NA, Di Maio S
Abstract
Hematospermia or hemospermia is defined as the presence of blood in ejaculate. The true prevalence of the condition is unknown because many cases escape the patient's notice, and remain unrecognized and unreported. There are two main aims in the patient evaluation: first, to ensure that there is no specific condition that is treatable; second, to reassure the patient's parents that no causative factor is present. Many physicians are unfamiliar with this disorder and this forms the basis for our current re...
Source: Pediatric Endocrinology Reviews - May 18, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
IMAGe and Related Undergrowth Syndromes: The Complex Spectrum of Gain-of-Function CDKN1C Mutations.
Authors: Cabrera-Salcedo C, Kumar P, Hwa V, Dauber A
Abstract
CDKN1C is a cyclin-dependent kinase Inhibitor and negative regulator of cellular proliferation. Recently, gain-of-function mutations in the PCNA domain of CDKN1C have been reported as the genetic basis of various growth-retarded syndromes including IMAGe syndrome, Russell Silver syndrome as well as a novel undergrowth syndrome that additionally exhibited early adulthood onset diabetes. This review summarizes the key clinical features and the molecular advances that have contributed to our understanding of this complex phenotypic spectrum.
...
Source: Pediatric Endocrinology Reviews - May 18, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Endocrine Disorders Developing after Surgical Intervention of Craniopharyngioma in Children.
Authors: Shohdy KS, Rashad W
Abstract
Craniopharyngiomas, albeit their benign nature, can cause severe damage to visual, hypothalamic, endocrine and neurologic functions which make their total resection an inevitable approach to save the patient's life. However, significant therapy-related long term complications make those traditional treatment options debatable and hazardous. This review will focus on the various complications that affect the childrens' quality of life considerably such as, diabetes insipidus, precocious puberty and hypothalamic obesity.
PMID: 28508600 [PubMed - in process] (Sour...
Source: Pediatric Endocrinology Reviews - May 18, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Effects of Anorexia Nervosa on the Endocrine System.
Authors: Baskaran C, Misra M, Klibanski A
Abstract
Anorexia nervosa (AN) is characterized by severe undernutrition associated with alterations in multiple endocrine axes, which are primarily adaptive to the state of caloric deprivation. Hormonal changes include growth hormone (GH) resistance with low insulin like growth factor-1 (IGF-1) levels, hypothalamic hypogonadism, relative hypercortisolemia and changes in appetite regulating hormones, including leptin, ghrelin, and peptide YY. These alterations contribute to abnormalities in bone metabolism leading to low bone mass, impaired bone microarchitecture, ...
Source: Pediatric Endocrinology Reviews - May 18, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Succinate-Dehydrogenase Deficient Paragangliomas/Pheochromocytomas: Genetics, Clinical Aspects and Mini- Review.
Authors: Rusyn L, Kohn B
PMID: 28508602 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - May 18, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Meeting Reports: Adolescence - a Transition to Adulthood Proceedings of the 24th Aschauer Soiree, held at Jurata, Poland, November 5th 2016.
Authors: Koziel S, Hermanussen M, Gomula A, Swanson J, Kaczmarek M, El-Shabrawi M, Elhusseini M, Satake T, Martinović IK, Scheffler C, Morkuniene R, Godina E, Saša M, Janina T, Anna S, Nieczuja-Dwojacka J, Núñez J, Groth D, Barbieri D
PMID: 28508603 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - May 18, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
For Debate: Growth Hormone Treatment of Infants Born Small for Gestational Age should be Started at or before the First Year of Age.
Authors: Laron Z, Laron-Kenet T, Klinger G
Abstract
Children born small for gestational age without early catch-up of somatic growth and head circumference subsequently remain short and suffer from various degrees of neurocognitive and psychological impairment. Based upon the role of growth hormone (GH) and insulin-like growth factor-I on early brain growth and maturation, we propose that GH treatment of these infants be instituted prior to their 2nd birthday.
PMID: 28508604 [PubMed - in process] (Source: Pediatric Endocrinology Reviews)
Source: Pediatric Endocrinology Reviews - May 18, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Disorders of Adrenal Steroidogenesis: Impact on Gonadal Function and Sex Development.
Authors: Mooij CF, van Herwaarden AE, Claahsen-van der Grinten HL
Abstract
A defect in adrenal steroidogenesis may cause a disorder of sex development (DSD). Importantly, DSD of adrenal origin is not restricted to a genital phenotype but is in most cases accompanied by mild to severe impairment in glucocorticoid and/or mineralocorticoid synthesis. If a patient is suspected of DSD of adrenal origin evaluation of glucocorticoid and mineralocorticoid metabolism is therefore essential to provide adequate medical care in the case of a severe and potentially life-threatening insufficiency. The adrenal steroidoge...
Source: Pediatric Endocrinology Reviews - May 18, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
