Punica granatum (Pomegranate) activity in health promotion and cancer prevention
Cancer has become one of the most fatal diseases in most countries. In spite of the medical care developing, cancer still remains a significant problem. The majority of the cancers are resistant to treatment. Thus, the research for novel, more efficient and less side effect treatment methods continues. Pomegranate contains strong antioxidant activity, with potential health interests. Research concern in pomegranate is increasing because of their anticancer potential due to possess rich in polyphenols. We highlight the pomegranate potential health benefits and mechanism of cancer progression inhibition. Pomegranate has indi...
Source: Oncology Reviews - January 30, 2018 Category: Cancer & Oncology Source Type: research
Post-transcriptional regulation of microRNAs in cancer: from prediction to validation
MicroRNA (miRNA) is a small non-coding RNA with an established function to regulate genes at the post-transcriptional level leading to suppression or degradation of its messenger RNA expression (mRNA). Its dysregulation plays a vital role in a variety of biological and pathological processes including cancer. A lot of algorithms have been established to predict the target sites of miRNA, but experimentally identifying and validating its target region is still lacking. Guidance in experimental procedures is really needed to find genuine miRNA targets. Therefore, in this review, we provide an outline on the workflow in predi...
Source: Oncology Reviews - January 29, 2018 Category: Cancer & Oncology Source Type: research
Time to tame necroptosis - viable combat against chemo resistant oral cancer cells
Not available (Source: Oncology Reviews)
Source: Oncology Reviews - January 29, 2018 Category: Cancer & Oncology Source Type: research
Saudi anti-human cancer plants database (SACPD): A collection of plants with anti-human cancer activities
Several anticancer drugs have been developed from natural products such as plants. Successful experiments in inhibiting the growth of human cancer cell lines using Saudi plants were published over the last three decades. Up to date, there is no Saudi anticancer plants database as a comprehensive source for the interesting data generated from these experiments. Therefore, there was a need for creating a database to collect, organize, search and retrieve such data. As a result, the current paper describes the generation of the Saudi anti-human cancer plants database (SACPD). The database contains most of the reported informa...
Source: Oncology Reviews - January 29, 2018 Category: Cancer & Oncology Source Type: research
Developing a comprehensive Cardio-Oncology Program at a Cancer Institute: the Moffitt Cancer Center experience
Cardio-oncology is a multidisciplinary field focusing on the management and prevention of cardiovascular complications in cancer patients and survivors. While the initial focus of this specialty was on heart failure associated with anthracycline use, novel anticancer agents are increasingly utilized and are associated with many other cardiotoxicities including hypertension, arrhythmias and vascular disease. Since its inception, the field has developed at a rapid pace with the establishment of programs at many major academic institutions and community practices. Given the complexities of this patient population, it is impor...
Source: Oncology Reviews - July 18, 2017 Category: Cancer & Oncology Source Type: research
Carcinogenesis-relevant biological events in the pathophysiology of the efferocytosis phenomenon
The effective removal of cells undergoing programmed cell death, which is referred to asefferocytosis, prevents the leakage of intracellular contents into the surrounding tissue, which could lead to tissue damage and inflammation. Efferocytosis involves a coordinated orchestration of multiple steps that lead to a swift, coherent and immunologically silent removal of dying cells. The release of wound healing cytokines, which resolve inflammation and enhance tissue repair, is an important feature of efferocytosis. However, in addition to the healing cytokines released during efferocytosis, the immunosuppressive action of cyt...
Source: Oncology Reviews - June 14, 2017 Category: Cancer & Oncology Source Type: research
Povidone-iodine for the management of oral mucositis during cancer therapy
The objective of the present study was to review evidence for the use of PVP-I for OM management. An algorithm identified relevant articles published online, and a panel of experts with experience in the management of OM reviewed the findings. Six studies fulfilled the criteria for full review. Two studies provided evidence of moderate quality. Two of the studies with negative findings were confounded by the use of PVP-I concentrations that are too low to be efficacious. The remaining two studies were found to have design flaws. There exists reasonable evidence to support a recommendation for the use of PVP-I in the manage...
Source: Oncology Reviews - June 14, 2017 Category: Cancer & Oncology Source Type: research
Centralization of liver cancer surgery and impact on multidisciplinary teams working on stage IV colorectal cancer
Surgical resection is the most effective treatment approach for colorectal liver metastases but only a minority of patients is suitable for upfront surgery. The treatment strategies of stage IV colorectal cancer have shifted towards a continuum of care in which medical and surgical treatment combinations are tailored to the clinical setting of the individual patient. The optimization of treatment through appropriate decision-making and multimodal therapy for stage IV colorectal cancer require a joint multidisciplinary meeting in a centralized liver cancer unit. (Source: Oncology Reviews)
Source: Oncology Reviews - June 14, 2017 Category: Cancer & Oncology Source Type: research
Current management options in metastatic renal cell cancer
This article reviews the past, present and future options in the management of metastatic renal cancer. (Source: Oncology Reviews)
Source: Oncology Reviews - June 14, 2017 Category: Cancer & Oncology Source Type: research
Novel strategies to improve the endocrine therapy of breast cancer
Endocrine therapy (ET) constitutes the usual first-line of therapy for patients in the treatment of metastatic hormone receptorpositive breast cancer. Unfortunately, not all patients respond to first-line endocrine treatment due to intrinsic resistance, while others may initially respond but eventually progress with secondary acquired resistance leading to disease progression. Mechanisms of resistance to anti-estrogen therapy include, loss of expression for estrogen or progesterone receptor, upregulation of epidermal receptor growth factor 2, increased receptor tyrosine kinase signaling, leading to activation of various in...
Source: Oncology Reviews - March 3, 2017 Category: Cancer & Oncology Source Type: research
Bone metastases: an overview
Bone is a frequent site of metastases and typically indicates a short-term prognosis in cancer patients. Once cancer has spread to the bones it can rarely be cured, but often it can still be treated to slow its growth. The majority of skeletal metastases are due to breast and prostate cancer. Bone metastasis is actually much more common than primary bone cancers, especially in adults. The diagnosis is based on signs, symptoms and imaging. New classes of drugs and new interventions are given a better quality of life to these patients and improved the expectancy of life. It is necessary a multidisciplinary approach to treat ...
Source: Oncology Reviews - March 3, 2017 Category: Cancer & Oncology Source Type: research
Journey of TRAIL from bench to bedside and its potential role in immuno-oncology
Induction of apoptosis in cancer cells has increasingly been the focus of many therapeutic approaches in oncology field. Since its identification as a TNF family member, TRAIL (TNF-related apoptosis-inducing ligand) paved a new path in apoptosis inducing cancer therapies. Its selective ability to activate extrinsic and intrinsic cell death pathways in cancer cells only, independently from p53 mutations responsible for conventional therapeutics resistance, spotted TRAIL as a potent cancer apoptotic agent. Many recombinant preparations of TRAIL and death receptor targeting monoclonal antibodies have been developed and being ...
Source: Oncology Reviews - March 3, 2017 Category: Cancer & Oncology Source Type: research
Chemotherapy resistance mechanisms in advanced skin cancer
Melanoma is a most dangerous and deadly type of skin cancer, and considered intrinsically resistant to both radiotherapy and chemotherapy. It has become a major public health concern as the incidence of melanoma has been rising steadily over recent decades with a 5-year survival remaining less than 5%. Detection of the disease in early stage may be curable, but late stage metastatic disease that has spread to other organs has an extremely poor prognosis with a median survival of less than 10 months. Since metastatic melanoma is unresponsive to therapy that is currently available, research is now focused on different treatm...
Source: Oncology Reviews - March 3, 2017 Category: Cancer & Oncology Source Type: research
