Epithelial-mesenchymal interconversions in ovarian cancer: the levels and functions of E-cadherin in intraabdominal dissemination
The metastatic process of ovarian cancer (OC) is almost exclusively defined by direct shedding of tumor cells into the abdominal cavity, followed by clustering into multicellular aggregates and posterior peritoneal anchorage. This process relies on dynamic intercellular interactions which are modified by epithelial-mesenchymal interconversions and, therefore, E-cadherin expression variability. Although widely accepted as a tumor suppressor in many types of cancer, E-cadherin is currently known to have a dynamic expression and a much more complex role in OC. First, high E-cadherin expression is considered a sign of metaplas...
Source: Oncology Reviews - May 29, 2020 Category: Cancer & Oncology Authors: Ricardo J. Roque, Margarida Figueiredo Dias, Filipa Costa Sousa Source Type: research
Role of Toll like receptor in progression and suppression of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is one of the most common type of head and neck squamous cell carcinoma and one of the multifactorial process that consists of most contributing factors such as tobacco smoking, chewing and alcohol consumption that altered the intracellular environment. Recent studies have shown relevance of Toll like receptor (TLR) associated with carcinogenesis. This review aim ’s to explore that how TLR associates with progression and suppression of OSCC. This review is a classical review that has confined to articles published in the past 19 years (i.e. 2000-2019) and has summarized the perspective...
Source: Oncology Reviews - May 19, 2020 Category: Cancer & Oncology Authors: Yash Sharma, Kumud Bala Source Type: research
EPAC2: A new and promising protein for glioma pathogenesis and therapy
Gliomas are prime brain cancers which are initiated by malignant modification of neural stem cells, progenitor cells and differentiated glial cells such as astrocyte, oligodendrocyte as well as ependymal cells. Exchange proteins directly activated by cAMP (EPACs) are crucial cyclic adenosine 3 ’,5’-monophosphate (cAMP)-determined signaling pathways. Cyclic AMP-intermediated signaling events were utilized to transduce protein kinase A (PKA) leading to the detection of EPACs or cAMP-guanine exchange factors (cAMP-GEFs). EPACs have been detected as crucial proteins associated with the pa thogenesis of neurological disorde...
Source: Oncology Reviews - April 30, 2020 Category: Cancer & Oncology Source Type: research
Elucidating the pathogenic and biomarker potentials of < em > FOXG1 < /em > in glioblastoma
Glioblastoma (GB) is an extremely pugnacious brain cancer originating from neural stem (NS) cell-like cells. Forkhead box G1 (FOXG1; previously recognized as BF-1, qin, Chicken Brain Factor 1, or XBF-1 and renamed FOXG1 for mouse and human, and FoxG1 for other chordates) is an evolutionary preserved transcription factor driven from the forkhead box group of proteins FOXG1 modulates the speed of neurogenesis by maintaining progenitor cells in a proliferative mode as well as obstructing their differentiation into neurons during the initial periods of cortical formation. FOXG1 has been implicated in the formation of central n...
Source: Oncology Reviews - April 30, 2020 Category: Cancer & Oncology Authors: Seidu A. Richard, Zhou Jia-hao Source Type: research
Elucidating the pathogenic and biomarker potentials of FOXG1 in glioblastoma
Glioblastoma (GB) is an extremely pugnacious brain cancer originating from neural stem (NS) cell-like cells. Forkhead box G1 (FOXG1; previously recognized as BF-1, qin, Chicken Brain Factor 1, or XBF-1 and renamed FOXG1 for mouse and human, and FoxG1 for other chordates) is an evolutionary preserved transcription factor driven from the forkhead box group of proteins FOXG1 modulates the speed of neurogenesis by maintaining progenitor cells in a proliferative mode as well as obstructing their differentiation into neurons during the initial periods of cortical formation. FOXG1 has been implicated in the formation of central n...
Source: Oncology Reviews - April 30, 2020 Category: Cancer & Oncology Source Type: research
RETRACTION: The biological mechanism involved in anticancer properties of amniotic membrane
To our readers:With deep regrets, we inform our Readers that the articleThe biological mechanism involved in anticancer properties of amniotic membrane (DOI:https://doi.org/10.4081/oncol.2020.429), which has been published in the current issue of Oncology Reviews (2020-1), contains verbatim text plagiarized from another paper.1The manuscript must be considered as retracted.On behalf of the Editorial Board ofOncology Reviews, I apologize to the Author of the manuscript whose text was plagiarized byAmeneh Jafari, Hassan Niknejad, Mostafa Rezaei-Tavirani, Caitlin D ’Amico, Hakimeh Zali that this was not picked up in the pee...
Source: Oncology Reviews - April 27, 2020 Category: Cancer & Oncology Source Type: research
Periodontitis and oral cancer - current concepts of the etiopathogenesis
Gingival tissues are attacked by oral pathogens which can induce inflammatory reactions. The immune-inflammatory responses play essential roles in the patient susceptibility to periodontal diseases. There is a wealth of evidence indicating a link between chronic inflammation and risk of malignant transformation of the affected oral epithelium. Periodontitis is associated with an increased risk of developing chronic systemic conditions including autoimmune diseases and different types of cancers. Besides, some risk factors such as smoking , alcohol consumption and human papilloma virus have been found to be associated with ...
Source: Oncology Reviews - March 18, 2020 Category: Cancer & Oncology Source Type: research
Periodontitis Periodontitis and oral cancer - current concepts of the etiopathogenesis
Gingival tissues are attacked by oral pathogens which can induce inflammatory reactions. The immune-inflammatory responses play essential roles in the patient susceptibility to periodontal diseases. There is a wealth of evidence indicating a link between chronic inflammation and risk of malignant transformation of the affected oral epithelium. Periodontitis is associated with an increased risk of developing chronic systemic conditions including autoimmune diseases and different types of cancers. Besides, some risk factors such as smoking , alcohol consumption and human papilloma virus have been found to be associated with ...
Source: Oncology Reviews - March 18, 2020 Category: Cancer & Oncology Source Type: research
Perceived factors to providing palliative care for patients with cancer - a qualitative systematic review
Palliative care (PC) is one of the necessary cares given throughout a patient ’s experience with cancer. The aim of this study was to identify the perceived factors to providing PC for patients with cancer. Our study was a systematic review of qualitative literature. To this end, electronic databases, including CINAHL, PubMed, PsycINFO, Ovid, and Web of Science as well as P ersian databases were searched and qualitative studies on the role of PC in patients with cancer published between Jan 2008 and Dec 2017 were selected. Generally, 12 studies were reviewed. A thematic synthesis approach was used to analyze the data. Ex...
Source: Oncology Reviews - February 18, 2020 Category: Cancer & Oncology Authors: Haydeh Heidari, Marjan Mardani-Hamooleh, Masoud Amiri Source Type: research
Management of cytotoxic chemotherapy-induced hand-foot syndrome
Improvements in systemic cancer treatments have resulted in more patients surviving for prolonged periods of time on treatment. This has made treatment-related toxicity and quality of life concerns increasingly relevant. Hand-foot syndrome (HFS) is a common skin reaction to systemic therapy that should be anticipated with chemotherapeutic treatments such as pegylated liposomal doxorubicin, docetaxel, and fluoropyrimidines. In this review we discuss current knowledge of the diagnosis, incidence, pathogenesis, and management of hand-foot syndrome (HFS). Although HFS is not life threatening, it can cause significant discomfor...
Source: Oncology Reviews - February 18, 2020 Category: Cancer & Oncology Authors: Johannes J.M. Kwakman, Yannick S. Elshot, Cornelis J.A. Punt, Miriam Koopman Source Type: research
Prostate-specific antigen velocity in diagnosis and prognosis of prostate cancer - a systematic review
In this study, we qualitatively synthesized the currently available evidence from published studies regarding the PSAV role in PC. Electronic databases were searched to find relevant articles published until January 2019. Inclusion and exclusion criteria were applied to identify related papers. Eventually, data extraction followed by evidence synthesis was conducted. Full-text screening resulted in 42 included studies. Multiple definitions and intervals were used for PSAV calculation across studies. Results from the included studies were conflicting regarding the role of PSAV in detecting PC and predicting progression in a...
Source: Oncology Reviews - February 18, 2020 Category: Cancer & Oncology Authors: Arslaan Javaeed, Sanniya Khan Ghauri, Abdellatif Ibrahim, Mohamed Fahmy Doheim Source Type: research
Periocular basal cell carcinoma - clinical perspectives
Basal cell carcinoma (BCC) as a non-melanoma skin cancer type is the most common malignant tumor throughout the world. The incidence is higher in age over 60. The intense of exposure to ultraviolet radiation is one of the known risk factors. Over 50% of BCC of the periocular region initially occur on the lower lid and inner angle. Literature review of treatment options for basal cell carcinoma, which consist of surgery, or combined techniques plus vismodegib, radiotherapy and imiquimod. The first consideration for treatment of periocular BCC is radical surgical excision using Mohs micrographic technique. Functional and est...
Source: Oncology Reviews - February 18, 2020 Category: Cancer & Oncology Source Type: research
RETRACTED - The biological mechanism involved in anticancer properties of amniotic membrane
This paper has been retracted. See the Retraction note at: https://doi.org/10.4081/oncol.2020.493 (Source: Oncology Reviews)
Source: Oncology Reviews - February 18, 2020 Category: Cancer & Oncology Source Type: research
The biological mechanism involved in anticancer properties of amniotic membrane
The main role of amniotic membrane (AM), or amnion, is to protect the fetus from drying out and create an appropriate environment for its growth. AM is also a suitable candidate for the treatment of various diseases due to its unique characteristics. In recent years, a new line of research has focused on the anticancer properties of amnion and its potential use in cancer treatment. Thein vitroand in vivo studies indicate the anti-proliferative and proapoptotic activities, as well as the angioregulatory and immunomodulatory properties of the amniotic membrane. However, the exact mechanism and molecular basis of these antica...
Source: Oncology Reviews - February 18, 2020 Category: Cancer & Oncology Source Type: research
The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review
Surgical resection followed by concurrent radiation therapy and temozolomide (TMZ) chemotherapy is the current standard treatment for glioblastoma multiforme (GBM). The present metaanalysis investigated the impact of prolonged TMZ maintenance therapy (more than 6 cycles) in comparison with standard TMZ maintenance therapy (exactly six cycles) on overall survival (OS) and progression-free survival (PFS) of patients with GBM. A meta-analysis of the literature was conducted using Medline, PubMed, EMBASE and the Cochrane Library in accordance with PRISMA guidelines. Seven articles involving 1018 patients were included. The ove...
Source: Oncology Reviews - February 18, 2020 Category: Cancer & Oncology Source Type: research
