S1pr1 KO Mouse
Also known as:S1pr1tm1Rlp, sphingosine-1-phosphate receptor 1 KO mouse,S1P1 KO mouse, Edg1 KO mouseS1pr1 is a member of the sphingosine-1-phosphate G-protein coupled receptor family.S1pr1 is essential for vascular maturation during embryonic development and is also involved in cell survival, migration, adhesion, and proliferation. This receptor plays a role in the regulation of innate and adaptive immune responses by controlling lymphocyte egress from the thymus, spleen, bone marrow, and lymph nodes. It has also been implicated in the regulation of vascular function.S1pr1 KO mice exhibit embryonic hemorrhage leading to int...
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
Use of nitrite salts for the treatment of cardiovascular conditions (U.S. Patent 9, 387,224)
It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardi...
Source: NIDDK Research Resources - September 14, 2018 Category: Endocrinology Source Type: research
Anthrose Based Compositions and Related Methods US 2015/0265691
This invention provides a vaccine comprising (i) a conjugate of an anthrose-containing saccharide in an amount effective to enhance immunity against Bacillus anthracis in a subject, wherein the anthrose-containing saccharide is conjugated to a biomolecule via a linker, and (ii) a pharmaceutically acceptable carrier. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - August 30, 2018 Category: Endocrinology Source Type: research
Method for Spectrally Selective B1 Insensitive T2 Preparation Contrast Enhancement for High Field Magnetic Resonance Imaging
A T2 preparation sequence uses a segmented BIR-4 adiabatic pulse with two substantially equal delays and is insensitive to B1 field variations and can simultaneously suppress fat signals with low specific absorption rate (SAR). An adiabatic reverse half passage pulse is applied followed by a predetermined delay. An adiabatic full passage pulse is applied followed by a substantially equal delay, followed by an adiabatic half passage pulse. Fat signal suppression is achieved by increasing or decreasing either the first delay or the second delay. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - August 20, 2018 Category: Endocrinology Source Type: research
MUP-tTA Mouse
Tetracycline-responsive transcriptional activator driven by the liver-specific mouse major urinary protein promoter (MUP-tTA).TheE. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that was inhibited by tetracycline. The transcription activator was a fused protein consisting of a tetracycline repressor gene (tetR) that was only active in the presence of tetracycline and a herpes simplex virus protein (VP-16) transcription activating domain (Tet-Off). Transcription was induced only in the absence of tetracycline (Tet-Off). A liver-specific promoter such as the ...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
Methanocarba cycloalkyl Nucleoside Analogues (U.S. Patent Number 7,790,735)
The present invention provides novel nucleoside and nucleotide derivatives that are useful agonist or antagonists of P1 and P2 receptors. For example, the present invention provides a compound of formula A-M, wherein A is modified adenine or uracil and M is a constrained cycloalkyl group. The adenine or uracil is bonded to the constrained cycloalkyl group. The compounds of the present invention are useful in the treatment or prevention of various diseases including airway diseases (through A2B, A3, P2Y2 receptors), cancer (through A3, P2 receptors), cardiac arrhythmias (through A1 receptors), cardiac ischemia (through A1, ...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
(N)-Methanocarba Adenosine Derivatives and Their Dendrimer Conjugates as A3 Receptor Agonists (U.S. Patent Application Number 61/313,961)
Disclosed are (N)-methanocarba adenine nucleosides, e.g., of the formula (I): as A3 adenosine receptor agonists, pharmaceutical compositions comprising such nucleosides, and a method of use of these nucleosides, wherein A, a, R2, and R3 are as defined in the specification. These nucleosides are contemplated for use in the treatment a number of diseases, for example, inflammation, cardiac ischemia, stroke, asthma, diabetes, and cardiac arrhythmias. Also disclosed are conjugates comprising a dendrimer and one or more ligands, which are functionalized congeners of an agonist or antagonist of a receptor of the G-protein couple...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
mEpoR KO / Tg(hEpoR) Mouse
mEpoR-/- hEpoR+: The mouse Erythropoietin Receptor knockout that contains a human Erythropoietin Receptor transgene can be used to define the potency of recombinant erythropoietin preparations used to treat anemia associated with chronic kidney disease.Erythropoietin, acting by binding to Erythropoietin receptors (EpoR) on erythroid progenitor cells, is required for erythropoiesis. Absence of erythropoietin or the EpoR in mice interrupts erythropoiesis in the fetal liver and result in death at embryonic day 13.5. An 80-kb human EpoR transgene bred onto a mouse EpoR null background (provided by F. Constantini of Columbia Un...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
M5 Muscarinic receptor KO (Chrm5 tm1Jwe) Mouse
M5 Muscarinic Receptor Knockout: Deficiency of M5Rs reduces drug-seeking behavior.The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to Gi/Go. M5R knockout mice are viable and fertile, and have no major morphological abnormalities.M5 muscarinic ACh receptors are located in the central nervous system and may contribute to the cognitive-enhancing effects of ACh. M5R knockout mice show deficits in two hippocampus-dependent cognitive tasks, and exhibit reduced cerebral blood flow in the cerebral cortex and hi...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
M4 Muscarinic receptor KO (Chrm4 tm1Jwe) Mouse
M4 Muscarinic Receptor Knockout: Activation of M4R may reduce the reinforcing effect of drugs of abuse, and contribute to the analgesic effects observed after administration of muscarinic agonists.The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to Gi/Go. M4R knockout mice are viable and fertile, and have no major morphological abnormalities.Dopamine hyperactivity in subcortical areas such as the nucleus accumbens is a key feature associated with schizophrenia. M4 muscarinic receptors in the central ner...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to Gi/Go. M3 muscarinic ACh receptors are present in the central nervous system and the periphery.M3R knockout mice are viable and fertile, and have no major morphological abnormalities. They have a lean phenotype. This results from a combination of reduced caloric intake and increased energy expenditure. They eat less food than wild-type mice, possibly because a central cholinergic pathway that stimulates food intake is disrupted. They also expend more e...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
M2 Muscarinic receptor KO (Chrm2 tm1Jwe) Mouse
M2 Muscarinic Receptor Knockout: role in learning and memory, and mediating analgesic effectsof muscarinic agonistsThe five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to Gi/Go. M2R knockout mice are viable and fertile, and have no major morphological abnormalities.M2 muscarinic receptors are located in the central nervous system and the periphery. Studies with M2R knockout mice strongly suggest that the M2 receptor is the key presynaptic muscarinic receptor mediating the inhibition of hippocampal and corti...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
M1 Muscarinic receptor KO (Chrm1 tm1Jwe) Mouse
M1 Muscarinic Receptor Knockout: support involvement in cognitive processes.The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to Gi/Go. M1R knockout mice are viable and fertile, and have no major morphological abnormalities.M1 muscarinic receptors are located in higher brain regions of the central nervous system that are involved in cognitive processes. Studies in M1R knockout mice show that M1 receptors may be involved in cortical memory functions that require interactions between the cerebral cortex an...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
Low molecular weight thyroid stimulating hormone receptor (tshr) agonists (U.S. Patent Application Number WO 2010047674 A1)
NIH investigators have discovered a series of low molecular weight thyroid-stimulating hormone (TSH) receptor modulators for use in the procedure to detect residual thyroid cancer cells following thyroidectomy. As small molecules, these compounds are orally available and are expected to be less costly and more straightforward to produce than recombinant protein counterparts currently on the market. These compounds appear be orally available, would be less difficult and expensive to produce, and are also more potent and/or specific for the TSH receptor than other known small-molecule TSH receptor agonists. In addition to us...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
Inverse agonists and neutral antagonists for the tsh receptor (U.S. Patent Application Number WO 2011127388 A2)
TSHR inverse agonists and neutral antagonists that are useful for treating Graves' orbitopathy, Graves' hyperthyroidism and/or thyroid cancer. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research
