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Con: Meta-analysis: some key limitations and potential solutions
Meta-analysis, a statistical combination of results of several trials to produce a summary effect, has been subject to criticism in the past, mainly for the reasons of poor quality of included studies, heterogeneity between studies meta-analyzed and failing to address publication bias. These limitations can cause the results to be misleading, which is important if policy and practice decisions are based on systematic reviews and meta-analyses. We elaborate on these limitations and illustrate them with examples from the nephrology literature. Finally, we present some potential solutions, notably, education in meta-analysis ...
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Esterhuizen, T. M., Thabane, L. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Opponent's comments
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Esterhuizen, T. M., Thabane, L. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Pro: Meta-analysis: the case for
With ever-accumulating medical evidence for treatment benefits and harms, it is vital that clinicians are able to access and use up-to-date, best evidence in specific clinical scenarios involving individual patients—the primary goal of evidence-based medicine. In this article, we propose that meta-analysis, when properly conducted and reported in the context of a rigorous systematic review, is an indispensable tool for synthesis and interpretation of clinical evidence for the purpose of informing clinical decision-making by clinicians, patients and health care policy makers. Meta-analysis provides many benefits, incl...
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Mudge, D. W., Webster, A. C., Johnson, D. W. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Chronic kidney disease in low- and middle-income countries
Most of the global burden of chronic kidney disease (CKD) is occurring in low- and middle-income countries (LMICs). As a result of rapid urbanization in LMICs, a growing number of populations are exposed to numerous environmental toxins, high infectious disease burdens and increasing rates of noncommunicable diseases. For CKD, this portends a high prevalence related to numerous etiologies, and it presents unique challenges. A better understanding of the epidemiology of CKD in LMICs is urgently needed, but this must be coupled with strong public advocacy and broad, collaborative public health efforts that address environmen...
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Stanifer, J. W., Muiru, A., Jafar, T. H., Patel, U. D. Tags: NDT PERSPECTIVES Source Type: research

Defining end-stage renal disease in clinical trials: a framework for adjudication
Unlike definition of stroke and myocardial infarction, there is no uniformly agreed upon definition to adjudicate end-stage renal disease (ESRD). ESRD remains the most unambiguous and clinically relevant end point for clinical trialists, regulators, payers and patients with chronic kidney disease. The prescription of dialysis to patients with advanced chronic kidney disease is subjective and great variations exist among physicians and countries. Given the difficulties in diagnosing ESRD, the presence of estimated GFR <15 mL/min/1.7 3m2 itself has been suggested as an end point. However, this definition is still a surrog...
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Agarwal, R. Tags: IDEAS, CONJECTURES AND REFUTATIONS Source Type: research

Atherosclerosis determinants in renal disease: how much is homocysteine involved?
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Perna, A. F., Ingrosso, D. Tags: IN FOCUS Source Type: research

Risk factors for progressive polycystic liver disease: where do we stand?
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: D'Agnolo, H. M. A., Drenth, J. P. H. Tags: IN FOCUS Source Type: research

Lower cardiovascular mortality with high-volume hemodiafiltration: a cool effect?
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Daugirdas, J. T. Tags: IN FOCUS Source Type: research

author index
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 13, 2016 Category: Urology & Nephrology Tags: index Source Type: research

Mp742 * serum albumin level has association with both graft failure and mortality in kidney transplant recipients
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 13, 2016 Category: Urology & Nephrology Authors: Jeon, H. J., Rhee, S., Shin, D. H., Oh, J. Tags: RENAL TRANSPLANTATION. CLINICAL - 2 Source Type: research

Mp741 * age adapted immunosuppression for elderly kidney allograft recipients: balancing risks for cancer versus rejection
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 13, 2016 Category: Urology & Nephrology Authors: Jackson-Spence, F., Gillott, H., Tahir, S., Nath, J., Evison, F., Sharif, A. Tags: RENAL TRANSPLANTATION. CLINICAL - 2 Source Type: research

Mp740 * systemic fungal infection in renal transplant recipients
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 13, 2016 Category: Urology & Nephrology Authors: Elumalai, R. P., Singh, N., P, S. Tags: RENAL TRANSPLANTATION. CLINICAL - 2 Source Type: research

Mp739 * transplant renal artery stenosis : a case series
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 13, 2016 Category: Urology & Nephrology Authors: Vasseur, A.-S., Hazzan, M., Lemaitre, L., Kilani, M., Anglicheau, D., Caillard-Ohlmann, S., Choukroun, G., Godin, M., hurault de ligny, B., Mousson, C., Merville, P., Vigneau, C., Glowacki, F., Noel, C., Frimat, M. Tags: RENAL TRANSPLANTATION. CLINICAL - 2 Source Type: research

Mp738 * bone mineral density in living donor renal transplantation recipents associates with fibroblast growth factor23
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 13, 2016 Category: Urology & Nephrology Authors: Chen, Z., Haarhaus, M., Olauson, H., Barany, P., Wennberg, L., Ripsweden, J., Brismar, T., Bergström, I., Lindholm, B., Stenvinkel, P., Stenvinkel, P., Qureshi, A. R. Tags: RENAL TRANSPLANTATION. CLINICAL - 2 Source Type: research

Mp737 * the cd14+cd16+ monocytes worsen glucose metabolism after simultaneous pancreas and kidney transplantation
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 13, 2016 Category: Urology & Nephrology Authors: Rodelo-Haad, C., Agüera-Morales, M. L., Carmona, A., Carracedo, J., Rodriguez-Benot, A., Aljama, P. Tags: RENAL TRANSPLANTATION. CLINICAL - 2 Source Type: research