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Opponent's comments
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Kallenberg, C. G. M. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Con: Cyclophosphamide for the treatment of lupus nephritis
Kidney involvement is a major determinant for morbidity and mortality in patients with systemic lupus erythematosus. The treatment target of lupus renal disease is to induce and maintain remission and to minimize disease or treatment-related comorbidities. Cyclophosphamide (CYC), in conjunction with glucocorticoids, has conventionally been used for the initial treatment of lupus nephritis. However, the major concerns of CYC are its toxicities, such as infertility, urotoxicity and oncogenicity, which are particularly relevant in women of childbearing age. As a result, maintenance therapy of lupus nephritis with an extended ...
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Mok, C. C. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Opponent's comments
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Mok, C. C. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Pro: Cyclophosphamide in lupus nephritis
Based on efficacy and toxicity considerations, both low-dose pulse cyclophosphamide as part of the Euro-Lupus Nephritis protocol and mycophenolate mofetil (MMF) with corticosteroids may be considered for induction of remission in patients with proliferative lupus nephritis. The long-term follow-up data available for low-dose pulse cyclophosphamide, the fact that compliance is guaranteed with this regimen and economic issues all favour the Euro-Lupus regimen in this author's opinion. For maintenance treatment, either azathioprine (AZA) or MMF may be used; AZA is preferred in case pregnancy is planned, while MMF is preferred...
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Kallenberg, C. G. M. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Highlights of the 2015 ERA-EDTA congress: chronic kidney disease, hypertension
This paper reports the highlights in the field of chronic kidney disease (CKD) and hypertension of the last European Renal Association (ERA-EDTA) Congress (London, May 21–24, 2016). The items include an European survey on CKD epidemiology and a multicenter, open-label, randomized controlled trial on the effect of renal denervation for hypertension management. Furthermore, a polar view regarding ABPM for the diagnosis and the monitoring of hypertension in dialysis patients is presented. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Mallamaci, F. Tags: NDT PERSPECTIVES Source Type: research

Beat it early: putative renoprotective haemodynamic effects of oral hypoglycaemic agents
Diabetic kidney disease represents a considerable burden; around one-third of patients with type 2 diabetes develop chronic kidney disease. In health, the kidneys play an important role in the regulation of glucose homeostasis via glucose utilization, gluconeogenesis and glucose reabsorption. In patients with diabetes, renal glucose homeostasis is significantly altered with an increase in both gluconeogenesis and renal tubular reabsorption of glucose. Environmental factors, both metabolic (hyperglycaemia, obesity and dyslipidaemia) and haemodynamic, together with a genetic susceptibility, lead to the activation of pro-oxid...
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Gnudi, L., Karalliedde, J. Tags: IDEAS, CONJECTURES AND REFUTATIONS Source Type: research

Competing risks: you only die once
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Warnock, D. G. Tags: IN FOCUS Source Type: research

Connecting the dots on fibroblast growth factor 23 and left ventricular hypertrophy
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Gutierrez, O. M. Tags: IN FOCUS Source Type: research

Why minorities live longer on dialysis: an in-depth examination of the Danish nephrology registry
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Rhee, C. M., Kalantar-Zadeh, K., Norris, K. C. Tags: IN FOCUS Source Type: research

Unchain the heart: impact of left ventricular myocardial hypertrophy regression in kidney transplant outcomes
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Pecoits-Filho, R., Calice-Silva, V. Tags: IN FOCUS Source Type: research

Averting the legacy of kidney disease: focus on childhood
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Ingelfinger, J. R., Kalantar-Zadeh, K., Schaefer, F., on behalf of the World Kidney Day Steering Committee Tags: ERRATUM Source Type: research

Announcements
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Tags: Announcements Source Type: research

The effect of rituximab dose on infectious complications in ABO-incompatible kidney transplantation
Conclusions Standard RIT increased the risk of serious infection when compared with reduced-dose RIT. Reduced-dose RIT might be sufficient for ABOi KT without increasing the risk of serious infection. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Lee, J., Lee, J. G., Kim, S., Song, S. H., Kim, B. S., Kim, H. O., Kim, M. S., Kim, S. I., Kim, Y. S., Huh, K. H. Tags: Renal Transplantation Source Type: research

The DESCARTES-Nantes survey of kidney transplant recipients displaying clinical operational tolerance identifies 35 new tolerant patients and 34 almost tolerant patients
Conclusions In kidney transplantation, operational tolerance and almost tolerance are infrequent findings associated with excellent long-term death-censored graft survival. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Massart, A., Pallier, A., Pascual, J., Viklicky, O., Budde, K., Spasovski, G., Klinger, M., Sever, M. S., Sorensen, S. S., Hadaya, K., Oberbauer, R., Dudley, C., De Fijter, J. W., Yussim, A., Hazzan, M., Wekerle, T., Berglund, D., De Biase, C., Perez-Saez Tags: Renal Transplantation Source Type: research

Pre-dialysis serum sodium and mortality in a national incident hemodialysis cohort
Conclusions We observed a U-shaped association of time-varying pre-dialysis serum sodium and all-cause mortality in hemodialysis patients, suggesting that both hypo- and hypernatremia carry short-term risk in this population. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 22, 2016 Category: Urology & Nephrology Authors: Rhee, C. M., Ravel, V. A., Ayus, J. C., Sim, J. J., Streja, E., Mehrotra, R., Amin, A. N., Nguyen, D. V., Brunelli, S. M., Kovesdy, C. P., Kalantar-Zadeh, K. Tags: Intra- and extracorporeal treatments of kidney failure Source Type: research