China ’s lust for jaguar fangs imperils big cats
China’s lust for jaguar fangs imperils big cats
Nature 555, 7694 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-02314-5
Author: Barbara Fraser
Wildlife traffickers seek body parts from protected species to satisfy consumers in China. (Source: Nature)
Source: Nature - March 1, 2018 Category: Research Authors: Barbara Fraser Tags: News Source Type: research
UK university strike, quark pioneer and the ancient-genome boom
Nature 555, 7694 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-02389-0
Author:
The week in science: 23 February – 1 March. (Source: Nature)
Source: Nature - March 1, 2018 Category: Research Tags: Seven Days Source Type: research
Nature journals announce two steps to improve transparency
Nature 555, 7694 (2018). doi:10.1038/d41586-018-02563-4
Author:
Reporting summaries help authors to provide important details before review. (Source: Nature)
Source: Nature - March 1, 2018 Category: Research Tags: Editorial Source Type: research
Oil and gas emissions could far exceed current estimates
Nature 555, 7694 (2018). doi:10.1038/d41586-018-02581-2
Author:
Ethane and propane rises have been traced to the global fossil-fuel industry. Now governments need to act. (Source: Nature)
Source: Nature - March 1, 2018 Category: Research Tags: Editorial Source Type: research
A code of ethics to get scientists talking
Nature 555, 7694 (2018). doi:10.1038/d41586-018-02516-x
Author:
A set of guidelines could trigger positive action. (Source: Nature)
Source: Nature - March 1, 2018 Category: Research Tags: Editorial Source Type: research
Structure of the insulin receptor –insulin complex by single-particle cryo-EM analysis
Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis
Nature 556, 7699 (2018). doi:10.1038/nature26153
Authors: Giovanna Scapin, Venkata P. Dandey, Zhening Zhang, Winifred Prosise, Alan Hruza, Theresa Kelly, Todd Mayhood, Corey Strickland, Clinton S. Potter & Bridget Carragher
The insulin receptor is a dimeric protein that has a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels. Insulin receptor dysfunction has been associated with many diseases, including diabe...
Source: Nature - February 28, 2018 Category: Research Authors: Giovanna Scapin Venkata P. Dandey Zhening Zhang Winifred Prosise Alan Hruza Theresa Kelly Todd Mayhood Corey Strickland Clinton S. Potter Bridget Carragher Tags: Letter Source Type: research
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
; David R. Liu
A key limitation of the use of the CRISPR–Cas9 system for genome editing and other applications is the requirement that a protospacer adjacent motif (PAM) be present at the target site. For the most commonly used Cas9 from Streptococcus pyogenes (SpCas9), the (Source: Nature)
Source: Nature - February 28, 2018 Category: Research Authors: Johnny H. Hu Shannon M. Miller Maarten H. Geurts Weixin Tang Liwei Chen Ning Sun Christina M. Zeina Xue Gao Holly A. Rees Zhi Lin David R. Liu Tags: Article Source Type: research
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus
Glória Teixeira Sousa, Cristina Cunha, Yan Liu, Ten Feizi, Axel A. Brakhage, Kyung J. Kwon-Chung, Neil A. R. Gow, Matteo Zanda, Monica Piras, Chiara Zanato, Martin Jaeger, Mihai G. Netea, Frank L. van de Veerdonk, João F. Lacerda, António Campos, Agostinho Carvalho, Janet A. Willment, Jean-Paul Latgé & Gordon D. Brown
Resistance to infection is critically dependent on the ability of pattern recognition receptors to recognize microbial invasion and induce protective immune responses. One such family of receptors are the C-type lectins, which are central to antifungal immunity. These receptors activate key effe...
Source: Nature - February 28, 2018 Category: Research Authors: Mark H. T. Stappers Alexandra E. Clark Vishukumar Aimanianda Stefan Bidula Delyth M. Reid Patawee Asamaphan Sarah E. Hardison Ivy M. Dambuza Isabel Valsecchi Bernhard Kerscher Anthony Plato Carol A. Wallace Raif Yuecel Betty Hebecker Maria da Gl ória Tei Tags: Letter Source Type: research
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours
We report 142 driver genes in paediatric cancers, of which only 45% match those found in adult pan-cancer studies; copy number alterations and structural variants constituted the majority (62%) of events. Eleven genome-wide mutational signatures were identified, including one attributed to ultraviolet-light exposure in eight aneuploid leukaemias. Transcription of the mutant allele was detectable for 34% of protein-coding mutations, and 20% exhibited allele-specific expression. These data provide a comprehensive genomic architecture for paediatric cancers and emphasize the need for paediatric cancer-specific development of ...
Source: Nature - February 28, 2018 Category: Research Authors: Xiaotu Ma Yu Liu Yanling Liu Ludmil B. Alexandrov Michael N. Edmonson Charles Gawad Xin Zhou Yongjin Li Michael C. Rusch John Easton Robert Huether Veronica Gonzalez-Pena Mark R. Wilkinson Leandro C. Hermida Sean Davis Edgar Sioson Stanley Pounds Xueyuan Tags: Letter Source Type: research
The landscape of genomic alterations across childhood cancers
ke Pfaff, Daniel Hübschmann, Gideon Zipprich, Michael Heinold, Jürgen Eils, Christian Lawerenz, Serap Erkek, Sander Lambo, Sebastian Waszak, Claudia Blattmann, Arndt Borkhardt, Michaela Kuhlen, Angelika Eggert, Simone Fulda, Manfred Gessler, Jenny Wegert, Roland Kappler, Daniel Baumhoer, Stefan Burdach, Renate Kirschner-Schwabe, Udo Kontny, Andreas E. Kulozik, Dietmar Lohmann, Simone Hettmer, Cornelia Eckert, Stefan Bielack, Michaela Nathrath, Charlotte Niemeyer, Günther H. Richter, Johannes Schulte, Reiner Siebert, Frank Westermann, Jan J. Molenaar, Gilles Vassal, Hendrik Witt, Birgit Burkhardt, Christian P. Kratz, Ola...
Source: Nature - February 28, 2018 Category: Research Authors: Susanne N. Gr öbner Barbara C. Worst Joachim Weischenfeldt Ivo Buchhalter Kortine Kleinheinz Vasilisa A. Rudneva Pascal D. Johann Gnana Prakash Balasubramanian Maia Segura-Wang Sebastian Brabetz Sebastian Bender Barbara Hutter Dominik Sturm Elke Pfaff Da Tags: Article Source Type: research
The mechanism of eukaryotic CMG helicase activation
Diffley
The initiation of eukaryotic DNA replication occurs in two discrete stages: first, the minichromosome maintenance (MCM) complex assembles as a head-to-head double hexamer that encircles duplex replication origin DNA during G1 phase; then, ‘firing factors’ convert each double hexamer into two active Cdc45–MCM–GINS helicases (CMG) during S phase. This second stage requires separation of the two origin DNA strands and remodelling of the double hexamer so that each MCM hexamer encircles a single DNA strand. Here we show that the MCM complex, which hydrolyses ATP during double-hexamer formation, remains sta...
Source: Nature - February 28, 2018 Category: Research Authors: Max E. Douglas Ferdos Abid Ali Alessandro Costa John F. X. Diffley Tags: Letter Source Type: research
Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis
kiko C. Siomi
PIWI-interacting RNAs (piRNAs) are small regulatory RNAs that bind to PIWI proteins to control transposons and maintain genome integrity in animal germ lines. piRNA 3′ end formation in the silkworm Bombyx mori has been shown to be mediated by the 3′-to-5′ exonuclease Trimmer (Trim; known as PNLDC1 in mammals), and piRNA intermediates are bound with PIWI anchored onto mitochondrial Tudor domain protein Papi. However, it remains unclear whether the Zucchini (Zuc) endonuclease and Nibbler (Nbr) 3′-to-5′ exonuclease, both of which have pivotal roles in piRNA biogenesis in Drosophila, are required f...
Source: Nature - February 28, 2018 Category: Research Authors: Kazumichi M. Nishida Kazuhiro Sakakibara Yuka W. Iwasaki Hiromi Yamada Ryo Murakami Yukiko Murota Takeshi Kawamura Tatsuhiko Kodama Haruhiko Siomi Mikiko C. Siomi Tags: Letter Source Type: research
The SMAD2/3 interactome reveals that TGF β controls m6A mRNA methylation in pluripotency
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency
Nature 555, 7695 (2018). doi:10.1038/nature25784
Authors: Alessandro Bertero, Stephanie Brown, Pedro Madrigal, Anna Osnato, Daniel Ortmann, Loukia Yiangou, Juned Kadiwala, Nina C. Hubner, Igor Ruiz de los Mozos, Christoph Sadée, An-Sofie Lenaerts, Shota Nakanoh, Rodrigo Grandy, Edward Farnell, Jernej Ule, Hendrik G. Stunnenberg, Sasha Mendjan & Ludovic Vallier
The TGFβ pathway has essential roles in embryonic development, organ homeostasis, tissue repair and disease. These diverse effects are mediated t...
Source: Nature - February 28, 2018 Category: Research Authors: Alessandro Bertero Stephanie Brown Pedro Madrigal Anna Osnato Daniel Ortmann Loukia Yiangou Juned Kadiwala Nina C. Hubner Igor Ruiz de los Mozos Christoph Sad ée An-Sofie Lenaerts Shota Nakanoh Rodrigo Grandy Edward Farnell Jernej Ule Hendrik G. Stunnenb Tags: Letter Source Type: research
Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor
E. Morrisey
Functional tissue regeneration is required for the restoration of normal organ homeostasis after severe injury. Some organs, such as the intestine, harbour active stem cells throughout homeostasis and regeneration; more quiescent organs, such as the lung, often contain facultative progenitor cells that are recruited after injury to participate in regeneration. Here we show that a Wnt-responsive alveolar epithelial progenitor (AEP) lineage within the alveolar type 2 cell population acts as a major facultative progenitor cell in the distal lung. AEPs are a stable lineage during alveolar homeostasis but expa...
Source: Nature - February 28, 2018 Category: Research Authors: William J. Zacharias David B. Frank Jarod A. Zepp Michael P. Morley Farrah A. Alkhaleel Jun Kong Su Zhou Edward Cantu Edward E. Morrisey Tags: Letter Source Type: research
Environment dominates over host genetics in shaping human gut microbiota
er, Gal Malka, Bat Chen Wolf, Tali Avnit-Sagi, Maya Lotan-Pompan, Adina Weinberger, Zamir Halpern, Shai Carmi, Jingyuan Fu, Cisca Wijmenga, Alexandra Zhernakova, Eran Elinav & Eran Segal
Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut (Source: Nature)
Source: Nature - February 28, 2018 Category: Research Authors: Daphna Rothschild Omer Weissbrod Elad Barkan Alexander Kurilshikov Tal Korem David Zeevi Paul I. Costea Anastasia Godneva Iris N. Kalka Noam Bar Smadar Shilo Dar Lador Arnau Vich Vila Niv Zmora Meirav Pevsner-Fischer David Israeli Noa Kosower Gal Malka Ba Tags: Article Source Type: research
