Isavuconazole shortens the QTc interval
Mycoses,Volume 61, Issue 4, Page 256-260, April 2018. (Source: Mycoses)
Source: Mycoses - November 25, 2017 Category: Research Source Type: research
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Mycoses,Volume 61, Issue 4, Page 231-236, April 2018. (Source: Mycoses)
Source: Mycoses - November 25, 2017 Category: Research Source Type: research
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Mycoses,Volume 61, Issue 4, Page 256-260, April 2018. (Source: Mycoses)
Source: Mycoses - November 25, 2017 Category: Research Source Type: research
Isavuconazole shortens the QTc interval
ConclusionApart from one case report, these are the first data outside controlled clinical trials showing QTc shortening. Knowledge about cardiac effects of isavuconazole will serve to better manage the use of concomitant medications. (Source: Mycoses)
Source: Mycoses - November 25, 2017 Category: Research Authors: Sibylle C. Mellinghoff, Matteo Bassetti, Daniela D örfel, Stefan Hagel, Nicola Lehners, Andrzej Plis, Enrico Schalk, Antonio Vena, Oliver A. Cornely Tags: Original Article Source Type: research
Thank you to Reviewers
(Source: Mycoses)
Source: Mycoses - November 24, 2017 Category: Research Tags: THANK YOU TO REVIEWERS Source Type: research
Issue Information
(Source: Mycoses)
Source: Mycoses - November 24, 2017 Category: Research Tags: ISSUE INFORMATION Source Type: research
Use of cell surface protein typing for genotyping of azole ‐resistant and ‐susceptible Aspergillus fumigatus isolates in Iran
Summary
Aspergillus fumigatus is the leading cause of mortality in severely immunocompromised individuals. Understanding pathogen dispersion and relatedness is essential for determining the epidemiology of nosocomial infections. Therefore, the aim of this study was to investigate the diversity and putative origins of clinical and environmental azole‐susceptible and ‐resistant A. fumigatus isolates from Iran. In all, 79 isolates, including 64 azole‐susceptible and 15 ‐resistant isolates, were genotyped using the cell surface protein (CSP) gene. Seven distinct repeat types (r01, r02, r03, r04, r05, r06 and r07) and ...
Source: Mycoses - November 22, 2017 Category: Research Authors: Mahsa Falahatinejad, Afsane Vaezi, Hamed Fakhim, Mahdi Abastabar, Tahereh Shokohi, Nina Zahedi, Saham Ansari, Jacques F. Meis, Hamid Badali Tags: ORIGINAL ARTICLE Source Type: research
In vitro antifungal activity of amphotericin B and 11 comparators against Aspergillus terreus species complex
Summary
Aspergillus terreus infections are difficult to treat because of the intrinsic resistance to amphotericin B, and higher mortality compared to infections caused by other Aspergillus species. The aim of the present study was to determine the in vitro antifungal activity of amphotericin B and 11 comparators against clinical (n = 36) and environmental (n = 45) A. terreus isolates. In vitro antifungal susceptibility was performed using the CLSI M38‐A2 procedure. Amphotericin B exhibited the highest MICs (MIC range, 0.125‐4 μg/mL; MIC90, 2 μg/mL), followed by terbinafine (MIC range, 0.002‐1 μg/mL; MIC90,...
Source: Mycoses - November 22, 2017 Category: Research Authors: Afsane Vaezi, Hamed Fakhim, Amir Arastehfar, Tahereh Shokohi, Mohammad T. Hedayati, Sadegh Khodavaisy, Ali Rezaei ‐Matehkolaei, Parisa Badiee, Ferry Hagen, Cornelia Lass‐Flörl, Eric Dannaoui, Jacques F. Meis, Hamid Badali Tags: ORIGINAL ARTICLE Source Type: research
Reliable differentiation of Pneumocystis pneumonia from Pneumocystis colonisation by quantification of Major Surface Glycoprotein gene using real ‐time polymerase chain reaction
Summary
A clear differentiation between pneumonia due to Pneumocystis jirovecii and “colonisation” is required for optimal case management. A quantification of fungal burden using major surface glycoprotein (MSG) gene‐based real‐time PCR was undertaken for the same. Lower respiratory tract samples collected from 104 patients of clinically suspected Pneumocystis pneumonia (PCP) were subjected to quantitative PCR using MSG gene. Based on whether or not the cases were treated for PCP, the efficacy of qPCR to differentiate between “diseased” and “colonised” was evaluated. Standard curve of plasmid‐cloned gene...
Source: Mycoses - November 22, 2017 Category: Research Authors: Shivaprakash M. Rudramurthy, Megha Sharma, Madhubala Sharma, Pankaj Rawat, Anup Ghosh, Lakshmishree Venkatesan, Ritesh Aggarwal, Meenu Singh, Arunaloke Chakrabarti Tags: ORIGINAL ARTICLE Source Type: research
Correlation between fungal sensitisation in childhood persistent asthma and disease severity
Summary
Fungal sensitisation in adults is associated with severe asthma but prevalence and clinical significance of fungal sensitisation remains unclear in paediatric population. The aim of this study was to study the association of fungal sensitisation with disease severity in children with persistent asthma. One hundred children with persistent asthma in age group 7‐15 years, symptom duration >2 years and forced expiratory volume in first second >50% of expected were enrolled. Skin prick test (SPT) to 8 fungal antigens and total serum immunoglobulin E (IgE) were done. Fungal sensitisation was described as posit...
Source: Mycoses - November 22, 2017 Category: Research Authors: Aman Gupta, Meenu Singh, Arunaloke Chakrabarti, Joseph L. Mathew, Amit Rawat Tags: ORIGINAL ARTICLE Source Type: research
Real ‐world challenges and unmet needs in the diagnosis and treatment of suspected invasive pulmonary aspergillosis in patients with haematological diseases: An illustrative case study
Summary
Recent years have seen important advances in the diagnosis of invasive pulmonary aspergillosis (IPA), complemented by the introduction of new therapies. Despite this, IPA remains a major cause of infection‐related mortality in patients with haematological diseases. There are two main reasons for this. First, diagnosis of IPA remains a challenge, since risk factors and the clinical, radiological and mycological presentations vary not only by fungal disease stage, but also by patient group (eg neutropenic vs non‐neutropenic patients). Diagnosis is particularly challenging in patients receiving mould‐active prop...
Source: Mycoses - November 22, 2017 Category: Research Authors: Martin Hoenigl, Juergen Prattes, Peter Neumeister, Albert W ölfler, Robert Krause Tags: ORIGINAL ARTICLE Source Type: research
Deep facial mycosis due to Trichophyton verrucosum —molecular genetic identification of the dermatophyte in paraffin‐embedded tissue—case report and review of the literature
We report on an 80‐year‐old male patient with severe sycosis barbae who had no animal contact and was treated with systemic antibiosis without improvement. Microbial and mycological investigations using swabs from oozing lesions revealed Staphylococcus haemolyticus and Candida parapsilosis. Histology demonstrated fungal elements in hair follicles. Paraffin‐embedded material was subjected to further mycological analysis. For molecular diagnostics DNA was prepared from paraffin sections for real‐time polymerase chain reaction (RT‐PCR). For sequencing, DNA was isolated from paraffin‐embedded skin tissue and the IT...
Source: Mycoses - November 15, 2017 Category: Research Authors: Uwe Wollina, Gesine Hansel, Silke Uhrla ß, Constanze Krüger, Jacqueline Schönlebe, Uta‐Christina Hipler, Pietro Nenoff Tags: REVIEW ARTICLE Source Type: research
Evaluation of multiplex real ‐time PCR for identifying dermatophytes in clinical samples—A multicentre study
This study aimed to develop and test a platform for identifying the most common dermatophytes in Israel using multiplex real‐time polymerase chain reaction (RT‐PCR). Specific primers were designed for the multiplex system (LightCycler 480) according to known cultures and validated by reference isolates. The dermatophyte detection rate was compared to smear and culture in 223 clinical samples obtained from a tertiary medical centre. Inconsistencies between methods were evaluated by sequencing. The RT‐PCR was further evaluated in 200 community‐based samples obtained from a health maintenance organisation and 103 mili...
Source: Mycoses - November 15, 2017 Category: Research Authors: Shany Sherman, Maya Goshen, Orit Treigerman, Keren Ben ‐Zion, Marie‐Jeanne Carp, Noam Maisler, Inbal Binsky Ehrenreich, Aviva Kimchi, Sara Lifshitz, Gill Smollan, Batya Davidovici, Michael David, Emmilia Hodak, Rina Segal Tags: ORIGINAL ARTICLE Source Type: research
Increasing candidaemia incidence from 2004 to 2015 with a shift in epidemiology in patients preexposed to antifungals
SummaryCandidaemia is an important health problem in immunocompromised patients with an epidemiology varying with region, period and patient population involved. The occurrence of candidaemia and the associated species distribution over a 12‐year period at a large tertiary care centre in Belgium were analysed. The trend in incidence in the intensive care units (ICUs) and non‐ICUs was investigated as well as the influence of antifungal exposure on the species distribution. From 2004 until 2015, 865 candidaemia episodes occurred in 826 patients at the University Hospitals Leuven. Candida albicans (59%) remained the most ...
Source: Mycoses - November 15, 2017 Category: Research Authors: Berdieke Goemaere, Pierre Becker, Eric Van Wijngaerden, Johan Maertens, Isabel Spriet, Marijke Hendrickx, Katrien Lagrou Tags: ORIGINAL ARTICLE Source Type: research
Primary prophylaxis of invasive fungal infections with posaconazole or itraconazole in patients with acute myeloid leukemia or high ‐risk myelodysplastic syndromes undergoing intensive cytotoxic chemotherapy: a real world comparison
This article is protected by copyright. All rights reserved. (Source: Mycoses)
Source: Mycoses - November 10, 2017 Category: Research Authors: Mar Tormo, Ariadna P érez‐Martínez, Marisa Calabuig, Juan Carlos Hernández‐Boluda, Paula Amat, David Navarro, Carlos Solano Tags: Original Article Source Type: research
