Mechanisms of Ageing and Development This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Prognostic networks for unraveling the biological mechanisms of Sarcopenia
Publication date: Available online 21 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Ana Cernea, Juan Luis Fernández-Martínez, Enrique Juan de Andrés-Galiana, Zulima Fernández-Muñiz, Juan Carlos Bermejo-Millo, Laura González-Blanco, Juan José Solano, Pedro Abizanda, Ana Coto-Montes, Beatriz CaballeroAbstractSarcopenia is an age-related multifactorial process that involved several biological mechanisms, whose specific contribution and interplay is still unknown. The present study proposes prognostic networks based on machine learning approaches to unravel the interplay among those biological mechan...
Source: Mechanisms of Ageing and Development - August 22, 2019 Category: Geriatrics Source Type: research

Selective brain neuronal and glial losses without changes in GFAP immunoreactivity: Young versus mature adult Wistar rats
Publication date: Available online 9 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Leonardo D. Diene, Zaquer S.M. Costa-Ferro, Silvia Barbosa, Bruna Bueno Milanesi, Gabriele Zenato Lazzari, Laura Tartari Neves, Lisiê Valéria Paz, Paula Fernanda Ribas Neves, Vanessa Battisti, Lucas A. Martins, Gunther Gehlen, Régis Gemerasca Mestriner, Jaderson C. Da Costa, Léder L. XavierAbstractNormal ageing results in brain selective neuronal and glial losses. In the present study we analyze neuronal and glial changes in Wistar rats at two different ages, 45 days (young) and 420 days (mature adult), using Nissl st...
Source: Mechanisms of Ageing and Development - August 11, 2019 Category: Geriatrics Source Type: research

Inflamm-aging micrornas may integrate signals from food and gut microbiota by modulating common signalling pathways
Publication date: Available online 8 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Laura Teodori, Ilaria Petrignani, Angelica Giuliani, Francesco Prattichizzo, Felicia Gurău, Giulia Matacchione, Fabiola Olivieri, Sofia Coppari, Maria Cristina AlbertiniAbstractHuman gut microbiota, which comprises an extremely diverse and complex community of microorganisms inhabiting the intestinal tract, may be associated with inflammation and age-related chronic health conditions. However, the mechanism underlying this association is only recently beginning to emerge. Transfer and modulation of gene expression by die...
Source: Mechanisms of Ageing and Development - August 9, 2019 Category: Geriatrics Source Type: research

When will my mouse die? Life span prediction based on immune function, redox and behavioural parameters in female mice at the adult age
Publication date: Available online 2 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Irene Martínez de Toda, Carmen Vida, Luis Sanz San Miguel, Mónica De la FuenteAbstractThe identification of predictive markers of life span would help to unravel the underlying mechanisms influencing ageing and longevity. For this aim, 30 variables including immune functions, inflammatory-oxidative stress state and behavioural characteristics were investigated in ICR-CD1 female mice at the adult age (N = 38). Mice were monitored individually until they died and individual life spans were registered. Multiple linear ...
Source: Mechanisms of Ageing and Development - August 3, 2019 Category: Geriatrics Source Type: research

Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice
Publication date: Available online 2 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Allen Herbst, Austin N. Hoang, Wendy Woo, Debbie McKenzie, Judd M. Aiken, Richard A. Miller, David B. Allison, Nianjun Liu, Jonathan WanagatAbstractThe age-induced, exponential accumulation of mitochondrial DNA (mtDNA) deletion mutations contributes to muscle fiber loss. The causes of these mutations are not known. Systemic inflammation is associated with decreased muscle mass in older adults and is implicated in the formation of sporadic mtDNA deletions. Macrophage migration inhibitory factor knockout (MIF-KO) mice are l...
Source: Mechanisms of Ageing and Development - August 3, 2019 Category: Geriatrics Source Type: research