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Editorial Board
Publication date: October 2019Source: Mechanisms of Ageing and Development, Volume 183Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - October 26, 2019 Category: Geriatrics Source Type: research

Changes of the coronary arteries and cardiac microvasculature with aging: Implications for translational research and clinical practice
Publication date: Available online 21 October 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Francesco Piccirillo, Myriam Carpenito, Giuseppe Verolino, Camilla Chello, Annunziata Nusca, Mario Lusini, Cristiano Spadaccio, Francesco Nappi, Germano Di Sciascio, Antonio NennaAbstractAging results in functional and structural changes in the cardiovascular system, translating into a progressive increase of mechanical vessel stiffness, due to a combination of changes in micro-RNA expression patterns, autophagy, arterial calcification, smooth muscle cell migration and proliferation. The two pivotal mechanisms of aging-...
Source: Mechanisms of Ageing and Development - October 22, 2019 Category: Geriatrics Source Type: research

NF-κB signaling in skin aging
Publication date: Available online 18 October 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Yujia Wang, Lian Wang, Xiang Wen, Dan Hao, Nan Zhang, Gu He, Xian JiangAbstractSkin is the largest organ of the body, and is prone to be affected by external environmental factors. Skin aging is caused by both genetic and environmental factors. Furthermore, aging skin tissue is known to create a permissive tissue microenvironment that promotes the initiation, progression and resistance of cancer cells by promoting the senescence-associated secretory phenotype (SASP). Therefore, more attention should be paid to skin agin...
Source: Mechanisms of Ageing and Development - October 19, 2019 Category: Geriatrics Source Type: research

Glycoanalysis of the placental membrane glycoproteins throughout placental development
Publication date: Available online 4 October 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Dragana Robajac, Romana Masnikosa, Marek Nemčovič, Martina Križáková, Ľudmila Belická Kluková, Peter Baráth, Jaroslav Katrlík, Olgica NedićAbstractStructural changes of glycans are observed in different (patho)physiological conditions. Human placental membrane (glyco)proteins were isolated from the first and third trimester placentas of mothers at different ages. By using lectin microarray, we demonstrated that the placental membrane N-glycome contains several N-glycan groups: high mannose, asialylated and sia...
Source: Mechanisms of Ageing and Development - October 5, 2019 Category: Geriatrics Source Type: research

Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories
Publication date: Available online 28 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Jaana Van Gastel, Huan Cai, Wei-Na Cong, Wayne Chadwick, Caitlin Daimon, Hanne Leysen, Jhana O. Hendrickx, Robin De Schepper, Laura Vangenechten, Jens Van Turnhout, Jasper Verswyvel, Kevin G. Becker, Yongqing Zhang, Elin Lehrmann, William H. Wood, Bronwen Martin, Stuart MaudsleyAbstractIn most species, females live longer than males. An understanding of this female longevity advantage will likely uncover novel anti-aging therapeutic targets. Here we investigated the transcriptomic responses in the hypothalamus – a k...
Source: Mechanisms of Ageing and Development - September 29, 2019 Category: Geriatrics Source Type: research

Replicative senescence is distinguishable from DNA damage-induced senescence by increased methylation of promoter of rDNA and reduced expression of rRNA
Publication date: Available online 27 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Reiko Sanokawa-Akakura, Shin Akakura, Elena A. Ostrakhovitch, Siamak TabibzadehAbstractHuman fibroblasts become senescent after a limited number of replications or by diverse stresses, such as DNA damage. However, replicative and damage induced senescence are indistinguishable in respect to proliferation cessation and expression of senescence markers, senescence-associated β-galactosidase, p16 and p21. Here, we show that senescence types can be distinguished by reduced levels of 18S, 5.8S and 28S rRNA, in replicative...
Source: Mechanisms of Ageing and Development - September 28, 2019 Category: Geriatrics Source Type: research

Interferons: a molecular switch between damage and repair in ageing and Alzheimer’s disease
Publication date: Available online 18 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): N. Gorlé, R.E. VandenbrouckeAbstractAlzheimer’s disease was first described over 100 years ago, yet it remains incurable and affects 44 million people worldwide. Traditionally, research has largely focused on the amyloid cascade hypothesis, but interest in the importance of inflammation in the progression of the disease has recently been increasing. Interferons, a large family of cytokines that trigger the immune system, are believed to play a crucial role in the pathology of Alzheimer’s disease. This review focu...
Source: Mechanisms of Ageing and Development - September 20, 2019 Category: Geriatrics Source Type: research

Telomere length and physical performance among older people—The Helsinki Birth Cohort Study
Publication date: October 2019Source: Mechanisms of Ageing and Development, Volume 183Author(s): Max J. Åström, Mikaela B. von Bonsdorff, Mia-Maria Perälä, Minna K. Salonen, Taina Rantanen, Eero Kajantie, Mika Simonen, Pertti Pohjolainen, Markus J. Haapanen, Maria A. Guzzardi, Patricia Iozzo, Hannu Kautiainen, Johan G. ErikssonAbstractTelomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and 453 men from the...
Source: Mechanisms of Ageing and Development - September 16, 2019 Category: Geriatrics Source Type: research

Classical Monocytes from Older Adults Maintain Capacity for Metabolic Compensation during Glucose Deprivation and Lipopolysaccharide Stimulation
In conclusion, aged classical monocytes maintain effector and metabolic functions during glucose deprivation, at least in an ex vivo context. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - September 5, 2019 Category: Geriatrics Source Type: research

Ischemic Stroke In Neonatal And Adult Astrocytes
The objective of this paper is to review current information regarding astrocytes function after a stroke in neonatal and adult brain. Based on the current literature, there are some molecular differences related to blood brain barrier (BBB) homeostasis disruption, inflammation and reactive oxygen species (ROS) mediated injury between the immature and mature brain after an ischemic event. In particular, astrocytes, the main glial cells in brain, play a different role in neonatal and adult brain after stroke, as time course of glial activation is strongly age dependent. Moreover, the present review provides further insight ...
Source: Mechanisms of Ageing and Development - September 5, 2019 Category: Geriatrics Source Type: research

Telomere length and physical performance among older people – the Helsinki Birth Cohort Study
Publication date: Available online 3 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Max J. Åström, Mikaela B. von Bonsdorff, Mia-Maria Perälä, Minna K. Salonen, Taina Rantanen, Eero Kajantie, Mika Simonen, Pertti Pohjolainen, Markus J. Haapanen, Maria A. Guzzardi, Patricia Iozzo, Hannu Kautiainen, Johan G. ErikssonAbstractTelomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and 453 men...
Source: Mechanisms of Ageing and Development - September 4, 2019 Category: Geriatrics Source Type: research

Regulation of cellular senescence by retinoid X receptors and their partners
Publication date: Available online 30 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Nadine Martin, Xingjie Ma, David BernardABSTRACTCellular senescence is a response characterized by a stable cell proliferation arrest and a senescence-associated secretory phenotype (SASP) which can be induced by many stresses, including telomere shortening and oncogene activation. Senescence is crucially involved in a variety of physiopathological contexts, such as cancer and aging. Given the fundamental role of this process, senescence needs to be tightly regulated. In the last decade, the key implication of nuclear re...
Source: Mechanisms of Ageing and Development - August 31, 2019 Category: Geriatrics Source Type: research

Feed-forward Loop between Body Composition, Strength and Performance in Older Adults
We present evidence of a feed-forward loop relationship between certain components of the frailty syndrome: body composition, strength and physical performance level.The evidence has been found by performing statistical analysis on measures from 878 females and 588 males aged 60-97, participating in the Rancho Bernardo Study, followed for at least three visits over 12 years. In the analysis, we have used fat mass and lean mass (measured by whole body DXA scans), grip strength (measured by dynamometer) and time to get up and walk a certain distance. The results provide evidence of a feed-forward loop between these variables...
Source: Mechanisms of Ageing and Development - August 30, 2019 Category: Geriatrics Source Type: research

Publisher's Note
Publication date: September 2019Source: Mechanisms of Ageing and Development, Volume 182Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - August 30, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: September 2019Source: Mechanisms of Ageing and Development, Volume 182Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - August 30, 2019 Category: Geriatrics Source Type: research