Effects of type of light on mouse circadian behaviour and stress levels
Light is the principal synchronizing environmental factor for the biological clock. Light quantity (intensity), and light quality (type of light source) can have different effects. The aim of this study was to determine the effects of the type of light experienced from the time of birth on mouse growth, circadian behaviour and stress levels. We raised pigmented and albino mice under 24 h light–dark cycles of either fluorescent or white light-emitting diode (LED) light source during the suckling stage, and the animals were then exposed to various light environments after weaning and their growth rate, locomotor activi...
Source: Laboratory Animals - January 19, 2016 Category: Research Authors: Alves-Simoes, M., Coleman, G., Canal, M. M. Tags: Original Articles Source Type: research
Gender differences in a mouse model of chemotherapy-induced neuropathic pain
In conclusion, gender differences play a major role in neuropathic pain induced by paclitaxel. The differences between male and female animals should be considered in future studies and the findings should be generalized to humans with caution. (Source: Laboratory Animals)
Source: Laboratory Animals - January 19, 2016 Category: Research Authors: Naji-Esfahani, H., Vaseghi, G., Safaeian, L., Pilehvarian, A.-A., Abed, A., Rafieian-Kopaei, M. Tags: Original Articles Source Type: research
Special editorial for the 50th anniversary of Laboratory Animals Limited
(Source: Laboratory Animals)
Source: Laboratory Animals - January 19, 2016 Category: Research Tags: Editorial Source Type: research
Translated abstracts, in French, German and Spanish
(Source: Laboratory Animals)
Source: Laboratory Animals - January 19, 2016 Category: Research Tags: Translated abstracts Source Type: research
Lectures
(Source: Laboratory Animals)
Source: Laboratory Animals - November 16, 2015 Category: Research Tags: Abstracts Source Type: research
Scientific Program
(Source: Laboratory Animals)
Source: Laboratory Animals - November 16, 2015 Category: Research Tags: Scientific Program Source Type: research
Venue
(Source: Laboratory Animals)
Source: Laboratory Animals - November 16, 2015 Category: Research Tags: General Information Source Type: research
Contents
(Source: Laboratory Animals)
Source: Laboratory Animals - November 16, 2015 Category: Research Tags: Contents Source Type: research
Welcome letter
(Source: Laboratory Animals)
Source: Laboratory Animals - November 16, 2015 Category: Research Tags: Welcome letter Source Type: research
A harmonized health reporting format for international transfer of rodents. AALAS-FELASA Working Group on Health Monitoring of Rodents for Animal Transfer
(Source: Laboratory Animals)
Source: Laboratory Animals - September 25, 2015 Category: Research Authors: Prins, J.-B. Tags: Letter to the Editor Source Type: research
Blood microsampling from the ear capillary in non-human primates
Blood sampling from awake non-human primates (NHPs) is classically performed under constraint in the cephalic or saphenous vein. It is a challenging, potentially harmful and stressful procedure which may lead to biased results and raises ethical concerns. Laboratory NHPs undergo a head-restrained procedure allowing for a safer procedure of collecting blood from their ears. Using regular capillary blood collection devices 500 µL of blood can be easily withdrawn per puncture point, which is sufficient for performing most of the usual modern biological assays. This procedure has been validated by measuring total protein...
Source: Laboratory Animals - September 25, 2015 Category: Research Authors: Lefevre, A., Ballesta, S., Pozzobon, M., Charieau, J.-L., Duperrier, S., Sirigu, A., Duhamel, J.-R. Tags: Short Reports Source Type: research
Catheterization of the urethra in female pigs
Female pigs are commonly utilized as an animal model for biomedical research and require urethral catheterization. Sixteen pigs were anaesthetized for research purposes and required the placement of a urethral catheter. Post-mortem examination of the vaginas revealed the urethral opening to be consistently halfway from the mucocutaneous junction of the vulva to the cervix. A shallow diverticulum was also observed on the ventral floor of the urethral opening. To optimize conditions for success the pig should be carefully positioned supine, a vaginal speculum and light source should be used, the pig should be adequately anae...
Source: Laboratory Animals - September 25, 2015 Category: Research Authors: Musk, G., Zwierzchoniewska, M., He, B. Tags: Short Reports Source Type: research
Micturition in Gottingen minipigs: first reference in vivo data for urological research and review of literature
One possible symptom of overactive bladder (OAB) is urinary incontinence, which is generally considered to be an age-associated disease and which is rapidly increasing with demographic changes. Rodent models are commonly used for the investigation of lower urinary tract functions, although the use of these species has limitations in several translational aspects. In biomedical research and preclinical toxicology, Göttingen minipigs are used increasingly. But in urological research, only few data are available for Göttingen minipigs. To the best of our knowledge, this study is one of the first to provide reference...
Source: Laboratory Animals - September 25, 2015 Category: Research Authors: Huppertz, N., Tolba, R., Grosse, J. Tags: Original Articles Source Type: research
Monitoring of small laboratory animal experiments by a designated web-based database
This article demonstrates its fundamental features and the easy and secure access it offers to the data from any place using a web browser. This information will help other researchers create their own individual databases in a similar way. The use of QR-codes plays an important role for stress-free use of the database. We demonstrate a way to easily identify all animals and samples and data collected during the experiments. Specific ways to record animal irradiations and chemotherapy applications are shown. This new analysis tool allows the effective and detailed analysis of huge amounts of data collected through small an...
Source: Laboratory Animals - September 25, 2015 Category: Research Authors: Frenzel, T., Grohmann, C., Schumacher, U., Krull, A. Tags: Original Articles Source Type: research
Etomidate anaesthesia by immersion in oriental fire-bellied toads (Bombina orientalis)
The objective of the present study was to evaluate the efficacy and the safety of etomidate anaesthesia by immersion technique in Bombina orientalis. The study comprised two phases. The first phase was carried out to identify the etomidate concentration capable of producing anaesthetic induction, as well as surgical anaesthesia, in the toads. The second phase was aimed at testing that concentration in eight additional animals. Etomidate administered via immersion at a concentration of 37.5 mg/L produced effective anaesthesia in oriental fire-bellied toads. The average duration of surgical anaesthesia was 20 min. All the to...
Source: Laboratory Animals - September 25, 2015 Category: Research Authors: d'Ovidio, D., Spadavecchia, C., Angeli, G., Adami, C. Tags: Original Articles Source Type: research
