Uracil-coumarin based hybrid molecules as potent anti-cancer and anti-bacterial agents
Publication date: Available online 12 December 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Mohit Sanduja, Jyoti Gupta, Harbinder Singh, Piyusha P. Pagare, Abhineet RanaAbstractIn the current report, we have rationally designed a series of uracil-coumarin based bifunctional molecular hybrids roped by 1,2,3-triazole moiety. The designed compounds were synthesized and tested against a panel of six human cancer cell lines namely Colo-205, MCF-7, A-549, PA-1, PC-3 and Hela cells by Sulforhodamine B assay. The results indicated that the hybrid molecules can specifically inhibit the MCF-7 cancer cell proliferation amo...
Source: Journal of Saudi Chemical Society - December 13, 2019 Category: Chemistry Source Type: research
Remediation of Azo-dyes based toxicity by agro-waste cotton boll peels mediated palladium nanoparticles
Publication date: Available online 10 December 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Boya Palajonnala Narasaiah, Badal Kumar MandalAbstractThe present study reports an environmental benign route for the synthesis of palladium nanoparticles (Pd NPs) using agro-waste empty cotton boll peels aqueous extract for the first time. Surface Plasmon Resonance (SRP) band in absorption spectrum of Pd NPs at 275 nm confirmed the formation of Pd NPs by using UV-Vis spectroscopy. Crystalline nature of Pd NPs was confirmed by powder XRD analysis. Size and morphology was studied by transmission electron microscopy (TEM). ...
Source: Journal of Saudi Chemical Society - December 10, 2019 Category: Chemistry Source Type: research
Facile Synthesis of Palladium Nanoparticles Supported on Urea-based Porous Organic Polymers and its Catalytic Properties in Suzuki-Miyaura Coupling
Publication date: Available online 30 November 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Pengwei Gao, Yongmei Xiao, Zhenhua Dong, Hongguo Pan, Wentao WangAbstractBy using urea linked porous organic polymers as template, a new nano palladium catalyst with low Pd loading can be easily prepared (1.0 wt% Pd only). Although such less amount of Pd was contained in this new catalyst, it is still an effective catalyst for the Suzuki-Miyaura coupling of aryl iodines and aryl boric acids, affording biphenyl products in excellent yields with outstandingly enhanced turnover numbers (up to 10536) under green solvent (wate...
Source: Journal of Saudi Chemical Society - December 1, 2019 Category: Chemistry Source Type: research
Synthesis and characterization of CuFe2O4/NiMgAl-LDH composite for the efficient removal of oxytetracycline antibiotic
In this study, a modified copper ferrite/NiMgAl layered double hydroxide (CuFe2O4/NiMgAl-LDH) composite was developed for the adsorptive removal of oxytetracycline hydrochloride (OTC) antibiotic from aqueous solution. Material characterization by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transforms infrared spectrum (FTIR) and X-ray photoelectron spectroscopy (XPS) confirms that the resultant material composes of a hexagonal layered doubled hydroxide structure with surficial deposits on CuFe2O4 cubes. The adsorption of OTC onto the prepared materials were studied as a function of solution pH, ini...
Source: Journal of Saudi Chemical Society - November 20, 2019 Category: Chemistry Source Type: research
Integration of naturally bioactive thiazolium and 1,3,4-oxadiazole fragments in a single molecular architecture as prospective antimicrobial surrogates
Publication date: Available online 11 November 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Huai-He Zhu, Dan Zeng, Ming-Wei Wang, Pei-Yi Wang, Yuan-Yuan Wu, Li-Wei Liu, Song YangAbstractPlant microbial diseases caused global production constraints have become one of the most challenging events, thus urgently needing to be addressed nowadays. To efficiently promote the discovery of promising antimicrobial surrogates, a type of 1,3,4-oxadiazole thioethers owning naturally bioactive thiazolium patterns was designed and fabricated. Antibacterial screening results revealed that title compounds could significantly inh...
Source: Journal of Saudi Chemical Society - November 12, 2019 Category: Chemistry Source Type: research
Microwave-promoted solvent-free synthesis of para-quinone methides (p-QMs) derivatives
Publication date: Available online 6 November 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Zhang-Qin Liu, Peng-Sheng You, Chuan-Hua Wu, Yang-Hong HanAbstractA rapid and efficient methodology for the synthesis of polysubstituted para-quinone methides (p-QMs) from aldehyde and 2,6-di-tert-butylphenol has been achieved in solvent-free and microwave irradiation condition within 33 min. This strategy displays the advantages including high atom economy, good functional group tolerance, and environmentally friendly operation. (Source: Journal of Saudi Chemical Society)
Source: Journal of Saudi Chemical Society - November 6, 2019 Category: Chemistry Source Type: research
Editorial Board
Publication date: November 2019Source: Journal of Saudi Chemical Society, Volume 23, Issue 7Author(s): (Source: Journal of Saudi Chemical Society)
Source: Journal of Saudi Chemical Society - October 31, 2019 Category: Chemistry Source Type: research
Facile CuCl2·2H2O catalyzed one-pot conversion of dimedone into highly functionalized indazole based N-arylhydrazinecarbothioamides
Publication date: Available online 17 September 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Rafaila Rafique, Syed Muhammad Saad, Arshia, Khalid Mohammed Khan, Shahnaz Perveen, Muhammad TahaAbstractA convenient and facile CuCl2·2H2O catalyzed one-pot synthetic strategy was designed for the conversion of readily available dimedone into highly functionalized N-arylhydrazinecarbothioamide based indazole derivatives. The product yields were found to be moderate to good without purification requirements. Structural features of the synthetic compounds were confirmed by various spectroscopic techniques such as 1H NMR,...
Source: Journal of Saudi Chemical Society - September 27, 2019 Category: Chemistry Source Type: research
Synthesis and Comparative Study of Catalytic Activity between Pd-Metallodendrimer and Pd/Cu-Bimetallodendrimer Nanoparticle-Based on Triazine
Publication date: Available online 26 September 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Md. Sayedul Islam, Md. Wahab KhanAbstractTriazine-based heterogeneous Pd/Cu-bimetallodendrimer Nanoparticle (Pd/Cu-BMDNP) has been synthesized by sequential loading method from palladium containing metallodendrimer (Pd-MD) which was prepared by the reaction of 2,4,6-Triamine-1,3,5-triazine (melamine) with substituted benzoyl chloride using (Ph3P)2PdCl2 in DMSO at 90 oC. SEM and EDX of Pd/Cu-BMDNP showed the nanosized aggregated spherical surface morphology and the presence of Palladium and copper of the NP. Also, the pha...
Source: Journal of Saudi Chemical Society - September 27, 2019 Category: Chemistry Source Type: research
Lightweight Excellent Microwave Absorption Properties Based on Sulfur Doped Graphene
Publication date: Available online 25 September 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Lin Tan, Menghui Zhu, Xiaoyang Li, Huixia Feng, Nali Chen, Dan ZhaoAbstractLightweight and high-efficiency electromagnetic wave (EMW) absorption sulfur doped graphene (S-GS) was fabricated by reducing and doping graphene oxide (GO) using chemical method. The obtained S-GS exhibits an extremely low reflection loss (RL), wide effective absorption frequency bandwidth at a thin coating thickness (d), light weight and low cost. The minimum RL reaches -52.3 dB at 17.5GHz with a matching thickness of 1.22mm. More excitedly, the...
Source: Journal of Saudi Chemical Society - September 26, 2019 Category: Chemistry Source Type: research
Application of silicon dioxide nanoparticles modified with tumor-targeting ligands for cellular delivery of nucleoside triphosphate analogues
Publication date: Available online 24 September 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Svetlana V. Vasilyeva, Albina S. Petrova, Alexander A. Shtil, Dmitry A. StetsenkoAbstractA key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery. To improve the efficacy for intracellular delivery, SiO2 nanoparticles were functionalized with tumor-targeting ligands folic acid, biotin or 5-fluorouracil. Studies of accumulation of these conjugates in HCT116 c...
Source: Journal of Saudi Chemical Society - September 25, 2019 Category: Chemistry Source Type: research
Chemical and Pharmacological aspects of Novel Hetero MLB complexes derived from NO2 type Schiff base and N2 type 1,10–Phenanthroline ligands
Publication date: Available online 17 September 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Somasundaram Hemalatha, Jeyaprakash Dharmaraja, Sutha Shobana, Paramasivam Subbaraj, Thirugnanasamy Esakkidurai, Natarajan RamanAbstractA series of hetero ligand MLB complexes (1–5) were synthesised from tridentate NO2 type Schiff base [H2L: (E)–2–((2–hydroxy–4–methoxyphenyl)(phenyl)methyleneamino)benzoic acid; derived from 2–hydroxy–4–methoxybenzophenone and 2–aminobenzoic acid] and bidentate N2 type 1,10–phenanthroline (B: phen) ligands. The structural characterization of the synthesised MLB compl...
Source: Journal of Saudi Chemical Society - September 18, 2019 Category: Chemistry Source Type: research
Synthesis of montmorillonite-based tris(2-ethylamine)-Schiff-base composites with remarkable antibacterial activity
Publication date: Available online 17 September 2019Source: Journal of Saudi Chemical SocietyAuthor(s): El-Refaie Kenawy, Mohamed R. Berber, Khalil Saad-Allah, Mohamed AzaamAbstractA range of heterogeneous, inexpensive and benign Schiff bases-montmorillonite composites were synthesized and screened for their antibacterial activity against common microbial pathogens. Sodium montmorillonite (Na-MMT) clay was modified with tris(2-ethylamine) in the presence of dilute HCl to yield a quaternary salt of tris(2-ethylamine) modified clay. The Schiff bases were then fabricated from the reaction of the modified montmorillonite using...
Source: Journal of Saudi Chemical Society - September 18, 2019 Category: Chemistry Source Type: research
Facile CuCl2.2H2O catalyzed one-pot conversion of dimedone into highly functionalized indazole based N-arylhydrazinecarbothioamides
Publication date: Available online 17 September 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Rafaila Rafique, Syed Muhammad Saad, Arshia, Khalid Mohammed Khan, Shahnaz Perveen, Muhammad TahaAbstractA convenient and facile CuCl2.2H2O catalyzed one-pot synthetic strategy was designed for the conversion of readily available dimedone into highly functionalized N-arylhydrazinecarbothioamide based indazole derivatives. The product yields were found to be moderate to good without purification requirements. Structural features of the synthetic compounds were confirmed by various spectroscopic techniques such as 1H-NMR, ...
Source: Journal of Saudi Chemical Society - September 18, 2019 Category: Chemistry Source Type: research
Morphology effect of ZnO support on the performance of Cu toward methanol production from CO2 hydrogenation
Publication date: Available online 12 September 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Guangyu Shi, Qing Chen, Qiuhong Zhang, Weijie Cai, Zhongcheng Li, Shangru Zhai, Hao Yu, Fengzhi Tan, Yuanhao WangAbstractRecently, the chemical conversion of the greenhouse gas CO2 into value-added methanol has been of great interest. To address this issue, ZnO nanorods were synthesized by a facile microwave assisted technique and selected as support in Cu/ZnO catalyst. Herein, structure-activity relationship of the as-prepared catalysts in CO2 hydrogenation to methanol were elucidated in detail using different character...
Source: Journal of Saudi Chemical Society - September 13, 2019 Category: Chemistry Source Type: research
