Molecular design of antimicrobial peptides based on hemagglutinin fusion domain to combat antibiotic resistance in bacterial infection
Antimicrobial peptides are derived from the viral fusion domain of influenza virus hemagglutinin based on rational analysis of the intermolecular interaction between peptides and bacterial outer membrane. It is revealed that the isolated viral fusion domain is a negatively charged peptide HAfp1‐23 that cannot effectively interact with the anionic membrane. Conversion of the native HAfp1‐23 to a positively charged peptide HAfp1‐23_KK by E11K/D19K mutation can promote the peptide‐membrane interaction substantially; this confers to the peptide a moderate antibacterial potency against antibiotic‐resistant bacterial s...
Source: Journal of Peptide Science - March 15, 2018 Category: Biochemistry Authors: Hui Ye Tags: RESEARCH ARTICLE Source Type: research
How are the expression patterns of gut antimicrobial peptides modulated by human gastrointestinal diseases? A bridge between infectious, inflammatory, and malignant diseases
The human gut barrier is the tissue exposed to the highest load of microorganisms, harbouring 100 trillion bacteria. In addition, the gut's renewal rate outruns that of any other human tissue. Antimicrobial peptides (AMPs) are highly optimized defense molecules in the intestinal barrier optimized to maintain gastrointestinal homeostasis. Alterations in AMPs activity can lead to or result from human gastrointestinal diseases. In this review, unique, conserved, or otherwise regular alterations in the expression patterns of human AMPs across gastrointestinal inflammatory and infectious diseases were analyzed for pattern eluci...
Source: Journal of Peptide Science - March 15, 2018 Category: Biochemistry Authors: Paulo Andr é Dias Bastos, Lúcio Lara Santos, Rui Miguel Pinheiro Vitorino Tags: REVIEW Source Type: research
Issue information
(Source: Journal of Peptide Science)
Source: Journal of Peptide Science - March 1, 2018 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
4 ‐Fluorophenyl 3‐nitro‐2‐pyridinesulfenate as a practical protecting agent for amino acids
Journal of Peptide Science,Volume 24, Issue 3, March 2018. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - February 15, 2018 Category: Biochemistry Source Type: research
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Journal of Peptide Science,Volume 24, Issue 3, March 2018. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - February 15, 2018 Category: Biochemistry Source Type: research
Respirable powder formulation of a shortened vasoactive intestinal peptide analog for treatment of airway inflammatory diseases
Journal of Peptide Science,Volume 24, Issue 3, March 2018. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - February 14, 2018 Category: Biochemistry Source Type: research
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Journal of Peptide Science,Volume 24, Issue 3, March 2018. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - February 14, 2018 Category: Biochemistry Source Type: research
Design of cyclic and d ‐amino acids containing peptidomimetics for inhibition of protein‐protein interactions of HER2‐HER3
HER2 receptors are surface proteins belonging to the epidermal growth factor family of receptors. Their numbers are elevated in breast, lung, and ovarian cancers. HER2‐positive cancers are aggressive, have higher mortality rate, and have a poor prognosis. We have designed peptidomimetics that bind to HER2 and block the HER2‐mediated dimerization of epidermal growth factor family of receptors. Among these, a symmetrical cyclic peptidomimetic (compound 18) exhibited antiproliferative activity in HER2‐overexpressing lung cancer cell lines with IC50 values in the nanomolar concentration range. To improve the stability of...
Source: Journal of Peptide Science - February 13, 2018 Category: Biochemistry Authors: Sandeep Pallerla, Himgauri Naik, Sitanshu Singh, Ted Gauthier, Rushikesh Sable, Seetharama D. Jois Tags: RESEARCH ARTICLE Source Type: research
New methodology for automated SPOT synthesis of peptides on cellulose using 1,3,5 ‐triazine derivatives as linkers and as coupling reagents
Two new rigid bi‐aromatic linkers for synthesis of peptide arrays by SPOT methodology were obtained from cellulose treated with 2,4‐dichloro‐6‐methoxy‐1,3,5‐triazine. Reaction with m‐phenylenediamine gave non‐cleavable TYPE I linker which enabled attachment of the peptides via resistant to harsh reaction conditions amide, ether, and amine bonds. Reaction with 3‐Fmoc‐aminobenzoic acid followed by thermal isomerization of the intermediate “superactive” ester producing an amide‐like bond gave TYPE II linker that was very stable during peptide synthesis. However, the peptide was cleavable, with fragme...
Source: Journal of Peptide Science - February 13, 2018 Category: Biochemistry Authors: Justyna Fraczyk, Ma łgorzata Walczak, Zbigniew J. Kaminski Tags: RESEARCH ARTICLE Source Type: research
Issue information
(Source: Journal of Peptide Science)
Source: Journal of Peptide Science - February 13, 2018 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
A practical diastereoselective synthesis of ( −)‐bestatin
Journal of Peptide Science,Volume 24, Issue 3, March 2018. (Source: Journal of Peptide Science)
Source: Journal of Peptide Science - February 12, 2018 Category: Biochemistry Source Type: research
