Zfhx3 is essential for progesterone/progesterone receptor signaling to drive ductal side-branching and alveologenesis in mouse mammary glands
Publication date: Available online 22 March 2019Source: Journal of Genetics and GenomicsAuthor(s): Gui Ma, Ang Gao, Yinan Yang, Yuan He, Xi Zhang, Baotong Zhang, Zhiqian Zhang, Mei Li, Xing Fu, Dan Zhao, Rui Wu, Leilei Qi, Qingxia Hu, Juan Li, Liya Fu, Zhengmao Zhu, Jin-Tang DongAbstractProgesterone (Pg)/progesterone receptor (PR) signaling drives mammary gland side-branching and alveologenesis, but the mechanisms through which Pg/PR signaling functions remain to be clarified. Using in vitro and in vivo models and histological and molecular analyses, we determined the role of Zfhx3 transcription factor in mammary gland dev...
Source: Journal of Genetics and Genomics - March 22, 2019 Category: Genetics & Stem Cells Source Type: research
CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice
Publication date: Available online 15 March 2019Source: Journal of Genetics and GenomicsAuthor(s): Jie Sun, Tao Tao, Wei Zhao, Lisha Wei, Fan She, Pei Wang, Yeqiong Li, Yanyan Zheng, Xin Chen, Wei Wang, Yanning Qiao, Xue-Na Zhang, Min-Sheng ZhuAbstractSeveral factors have been implicated in obesity-related hypertension, but the genesis of the hypertension is largely unknown. We found a significantly upregulated expression of CPI-17 and protein kinase C (PKC) isoforms in the vascular smooth muscles of the high fat diet (HFD)-fed obese mice. The obese wild-type mice showed a significant elevation of blood pressure and enhanc...
Source: Journal of Genetics and Genomics - March 16, 2019 Category: Genetics & Stem Cells Source Type: research
SAA-Cas9: a tunable genome editing system with increased bio-safety and reduced off-target effects
Publication date: Available online 15 March 2019Source: Journal of Genetics and GenomicsAuthor(s): Sanyuan Ma, Jianduo Zhang, Wei Lu, Yue Liu, Qingyou Xia (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - March 16, 2019 Category: Genetics & Stem Cells Source Type: research
PIK-75 promotes homology-directed DNA repair
Publication date: Available online 15 March 2019Source: Journal of Genetics and GenomicsAuthor(s): Guoling Li, Xianwei Zhang, Hao Ou, Haoqiang Wang, Dewu Liu, Huaqiang Yang, Zhenfang Wu (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - March 16, 2019 Category: Genetics & Stem Cells Source Type: research
Control of de novo root regeneration efficiency by developmental status of Arabidopsis leaf explants
Publication date: Available online 5 March 2019Source: Journal of Genetics and GenomicsAuthor(s): Jing Pan, Fei Zhao, Guifang Zhang, Yu Pan, Lijun Sun, Ning Bao, Peng Qin, Lyuqin Chen, Jie Yu, Yijing Zhang, Lin XuAbstractDe novo root regeneration (DNRR) has wide applications in agriculture such as those related to cutting technology. Detached Arabidopsis thaliana leaf explants can regenerate adventitious roots without added hormones. The regenerative ability is highly dependent on the developmental status of the leaf. An immature leaf has a higher regenerative ability, while a mature leaf is difficult to regenerate. Using ...
Source: Journal of Genetics and Genomics - March 6, 2019 Category: Genetics & Stem Cells Source Type: research
