Progressive heterosis in genetically defined tetraploid maize
In this study, four artificially induced maize tetraploids, directly derived from standard inbred lines, were crossed in pairs to create two single-cross hybrids. These hybrids were then crossed to create double-cross hybrids containing genetic material from all four original lines. Replicated field-based phenotyping of the materials over four years indicated a strong progressive heterosis phenotype in tetraploids but not in their diploid counterparts. In particular, the above ground dry weight phenotype of double-cross tetraploid hybrids was on average 34 % and 56% heavier than that of the single-cross tetraploid hybrids ...
Source: Journal of Genetics and Genomics - August 10, 2019 Category: Genetics & Stem Cells Source Type: research
Gut microbiota from end-stage renal disease patients disrupt gut barrier function by excessive production of phenol
Publication date: Available online 2 August 2019Source: Journal of Genetics and GenomicsAuthor(s): Xifan Wang, Yanling Hao, Xiaoxue Liu, Shoujuan Yu, Weibo Zhang, Songtao Yang, Zhengquan Yu, Fazheng Ren (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - August 2, 2019 Category: Genetics & Stem Cells Source Type: research
Mapping quantitative trait loci using binned genotypes
Publication date: Available online 23 July 2019Source: Journal of Genetics and GenomicsAuthor(s): Wen Yao, Guangwei Li, Yanru Cui, Yiming Yu, Qifa Zhang, Shizhong XuAbstractPrecise mapping of quantitative trait loci (QTLs) is critical for assessing the genetic effects and identification of candidate genes for quantitative traits. Interval and composite interval mappings have been the methods of choice for several decades, which have provided tools for identifying genomic regions harboring causal genes for quantitative traits. Historically, the concept was developed on the basis of sparse marker maps where genotypes of loci...
Source: Journal of Genetics and Genomics - July 25, 2019 Category: Genetics & Stem Cells Source Type: research
Production of non-mosaic genome edited porcine embryos by injection of CRISPR/Cas9 into germinal vesicle oocytes
In conclusion, GVGE might be a valuable method for the generation of non-mosaic maternal allele edited F0 embryos in a short simple step. (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - July 22, 2019 Category: Genetics & Stem Cells Source Type: research
Gene redundancy and gene compensation: an updated view
Publication date: Available online 19 July 2019Source: Journal of Genetics and GenomicsAuthor(s): Jinrong PengAbstractGene knockdown approaches using antisense oligo nucleotides or analogs such as siRNAs and morpholinos have been widely adopted to study gene functions although the off-target issue has been always a concern in these studies. On the other hand, classic genetic analysis relies on the availability of loss-of-function or gain-of-function mutants. The fast development of gene editing technologies such as TALEN and CRISPR/Cas9 has greatly facilitated the generation of null mutants for the functional studies of ta...
Source: Journal of Genetics and Genomics - July 20, 2019 Category: Genetics & Stem Cells Source Type: research
Rare variants in novel and known genes associated with primary angle closure glaucoma based on whole exome sequencing of 549 probands
Publication date: Available online 10 July 2019Source: Journal of Genetics and GenomicsAuthor(s): Wenmin Sun, Xueshan Xiao, Shiqiang Li, Jiamin Ouyang, Xueqing Li, Xiaoyun Jia, Xing Liu, Qingjiong Zhang (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - July 10, 2019 Category: Genetics & Stem Cells Source Type: research
Pyramiding of the dep1-1 and NAL1NJ6 alleles achieves sustainable improvements in nitrogen-use efficiency and grain yield in japonica rice breeding
Publication date: Available online 1 June 2019Source: Journal of Genetics and GenomicsAuthor(s): Xiaopeng Xu, Kun Wu, Ruineng Xu, Jianping Yu, Jing Wang, Ying Zhao, Yun Wang, Wenzhen Song, Shuoxun Wang, Zhi Gao, Yongjia Zhong, Xinxin Li, Hong Liao, Xiangdong Fu (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - June 30, 2019 Category: Genetics & Stem Cells Source Type: research
Dissecting PCNA function with a systematically designed mutant library in yeast
Publication date: Available online 24 June 2019Source: Journal of Genetics and GenomicsAuthor(s): Qingwen Jiang, Weimin Zhang, Chenghao Liu, Yicong Lin, Qingyu Wu, Junbiao DaiAbstractProliferating cell nuclear antigen (PCNA), encoded by POL30 in Saccharomyces cerevisiae, is a key component of DNA metabolism. Here, a library consisting of 304 PCNA mutants was designed and constructed to probe the contribution of each residue to the biological function of PCNA. Five regions with elevated sensitivity to DNA damaging reagents were identified using high-throughput phenotype screening. Using a series of genetic and biochemical a...
Source: Journal of Genetics and Genomics - June 25, 2019 Category: Genetics & Stem Cells Source Type: research
OsGCD1, a novel player in rice intine construction
Publication date: Available online 25 June 2019Source: Journal of Genetics and GenomicsAuthor(s): Xiaorong Huang, Mengmeng Run, Meng-Xiang Sun (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - June 25, 2019 Category: Genetics & Stem Cells Source Type: research
Nlrc3-like is required for microglia maintenance in zebrafish
Publication date: Available online 22 June 2019Source: Journal of Genetics and GenomicsAuthor(s): Tienan Wang, Bo Yan, Liang Lou, Xi Lin, Tao Yu, Shuting Wu, Qing Lu, Wei Liu, Zhibin Huang, Mingjie Zhang, Wenqing Zhang, Zilong WenAbstractMicroglia are tissue-resident macrophages resided in the central nervous system (CNS) and play critical roles in removing cellular debris and infectious agents as well as regulating neurogenesis and neuronal activities. Yet, the molecular basis underlying the establishment of microglia pool and the maintenance of their homeostasis in the CNS remain largely undefined. Here we report the ide...
Source: Journal of Genetics and Genomics - June 24, 2019 Category: Genetics & Stem Cells Source Type: research
A modified high-efficiency thermal asymmetric interlaced PCR method for amplifying long unknown flanking sequences
Publication date: Available online 23 June 2019Source: Journal of Genetics and GenomicsAuthor(s): Jiantao Tan, Qi Gong, Suize Yu, Yuke Hou, Dongchang Zeng, Qinlong Zhu, Yao-Guang Liu (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - June 24, 2019 Category: Genetics & Stem Cells Source Type: research
Mutations in TP53, ZNF750, and RB1 typify ocular sebaceous carcinoma
Publication date: Available online 21 June 2019Source: Journal of Genetics and GenomicsAuthor(s): Yongyang Bao, J. Eva Selfridge, Janet Wang, Yiqing Zhao, Junqi Cui, Kishore Guda, Zhenghe Wang, Yanbo Zhu (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - June 21, 2019 Category: Genetics & Stem Cells Source Type: research
RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila
Publication date: Available online 1 June 2019Source: Journal of Genetics and GenomicsAuthor(s): Ya Wang, Rui Xu, Yiwei Cheng, Haowei Cao, Zibin Wang, Tianyu Zhu, Jiayin Jiang, Hao Zhang, Chang Wang, Lin Qi, Mingxi Liu, Xuejiang Guo, Juan Huang, Jiahao ShaAbstractFlagellum in sperm is composed of over 200 different proteins and is essential for sperm motility. In particular, defects in the assembly of the radial spoke in the flagellum result in male infertility due to loss of sperm motility. However, mechanisms regulating radial spoke assembly remain unclear in metazoans. Here, we identified a novel Drosophila protein radi...
Source: Journal of Genetics and Genomics - June 3, 2019 Category: Genetics & Stem Cells Source Type: research
Pyramiding of the dep1-1 and NAL1NJ6 alleles achieves sustainable improvements in nitrogen use efficiency and grain yield in japonica rice breeding
Publication date: Available online 1 June 2019Source: Journal of Genetics and GenomicsAuthor(s): Xiaopeng Xu, Kun Wu, Ruineng Xu, Jianping Yu, Jing Wang, Ying Zhao, Yun Wang, Wenzhen Song, Shuoxun Wang, Zhi Gao, Yongjia Zhong, Xinxin Li, Hong Liao, Xiangdong Fu (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - June 3, 2019 Category: Genetics & Stem Cells Source Type: research
Genetic analysis and preimplantation genetic diagnosis of Chinese Marfan syndrome patients
Publication date: Available online 24 May 2019Source: Journal of Genetics and GenomicsAuthor(s): Meng Qin, Xiaohui Zhu, Zhe Zhang, Xuemin Li, Zhiqiang Yan, Yuqian Wang, Shuo Guan, Yihua He, Wenxin Zhang, Liying Yan, Jie Qiao, Xu Zhi (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - May 25, 2019 Category: Genetics & Stem Cells Source Type: research
