Dabigatran abrogates brain endothelial cell permeability in response to thrombin
del Zoppo (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Brian Thomas HawkinsYu-Huan GuYoshikane IzawaGregory John del Zoppo Tags: astrocyte dabigatran endothelial cell microvessel permeability barrier α-thrombin Source Type: research

Combined local blood–brain barrier opening and systemic methotrexate for the treatment of brain tumors
Combined local blood–brain barrier opening and systemic methotrexate for the treatment of brain tumors Journal of Cerebral Blood Flow & Metabolism advance online publication, February 11 2015. doi:10.1038/jcbfm.2015.6 Authors: Itzik Cooper, David Last, David Guez, Shirley Sharabi, Shirin Elhaik Goldman, Irit Lubitz, Dianne Daniels, Sharona Salomon, Gregory Tamar, Tzur Tamir, Ronni Mardor, Mati Fridkin, Yoram Shechter & Yael Mardor (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Itzik CooperDavid LastDavid GuezShirley SharabiShirin Elhaik GoldmanIrit LubitzDianne DanielsSharona SalomonGregory TamarTzur TamirRonni MardorMati FridkinYoram ShechterYael Mardor Tags: blood–brain barrier brain cancer convection glioma tight junctions Source Type: research

Cerebral autoregulation in the microvasculature measured with near-infrared spectroscopy
io Fantini (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Jana M KainerstorferAngelo SassaroliKristen T TgavalekosSergio Fantini Tags: brain imaging cerebral blood flow measurement cerebral hemodynamics near-infrared spectroscopy optical imaging Source Type: research

Ischemic tolerance in pre-myelinated white matter: the role of astrocyte glycogen in brain pathology
Journal of Cerebral Blood Flow & Metabolism advance online publication, February 11 2015. doi:10.1038/jcbfm.2015.3 Author: Robert Fern (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Robert Fern Tags: axon astrocyte glia glycogen ischemia white matter Source Type: research

Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for ‘collateral failure’ and infarct expansion after ischemic stroke
Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for ‘collateral failure’ and infarct expansion after ischemic stroke Journal of Cerebral Blood Flow & Metabolism advance online publication, February 11 2015. doi:10.1038/jcbfm.2015.2 Authors: Daniel J Beard, Damian D McLeod, Caitlin L Logan, Lucy A Murtha, Mohammad S Imtiaz, Dirk F van Helden & Neil J Spratt (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Daniel J BeardDamian D McLeodCaitlin L LoganLucy A MurthaMohammad S ImtiazDirk F van HeldenNeil J Spratt Tags: collaterals collateral failure experimental stroke infarct expansion intracranial pressure ischemic stroke stroke-in-progression Source Type: research

Approaching complete inhibition of P-glycoprotein at the human blood–brain barrier: an (R)-[11C]verapamil PET study
Approaching complete inhibition of P-glycoprotein at the human blood–brain barrier: an (R)-[11C]verapamil PET study Journal of Cerebral Blood Flow & Metabolism advance online publication, February 11 2015. doi:10.1038/jcbfm.2015.19 Authors: Martin Bauer, Rudolf Karch, Markus Zeitlinger, Cécile Philippe, Kerstin Römermann, Johann Stanek, Alexandra Maier-Salamon, Wolfgang Wadsak, Walter Jäger, Marcus Hacker, Markus Müller & Oliver Langer (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Martin BauerRudolf KarchMarkus ZeitlingerCécile PhilippeKerstin RömermannJohann StanekAlexandra Maier-SalamonWolfgang WadsakWalter JägerMarcus HackerMarkus MüllerOliver Langer Tags: blood–brain barrier P-glycoprotein pituitary gland positron emission tomography (R)-[11C]verapamil tariquidar Source Type: research

Glucagon-like receptor 1 agonists and DPP-4 inhibitors: potential therapies for the treatment of stroke
mp; Cesare Patrone (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Vladimer DarsaliaMartin LarssonDavid NathansonThomas KleinThomas NyströmCesare Patrone Tags: diabetes DPP-4 inhibitors exendin-4 GLP-1 liraglutide neuroprotection stroke Source Type: research

Tat-NR2B9c prevents excitotoxic neuronal superoxide production
nd A Swanson (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Yanting ChenAngela M Brennan-MinnellaSunil ShethJamel El-BennaRaymond A Swanson Tags: DNA damage glutamate ischemia nitric oxide oxidative stress stroke Source Type: research

Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease
Wardlaw & Karen Horsburgh (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Philip R HollandJames L SearcyNatalia SalvadoresGillian ScullionGuiquan ChenGreig LawsonFiona ScottMark E BastinMasafumi IharaRajesh KalariaEmma R WoodColin SmithJoanna M WardlawKaren Horsburgh Tags: cognition diffusion-tensor imaging hypoperfusion magnetic resonance imaging small vessel disease Source Type: research

Poly-arginine and arginine-rich peptides are neuroprotective in stroke models
p; Neville W Knuckey (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Bruno P MeloniLaura M BrookesVince W ClarkJane L CrossAdam B EdwardsRyan S AndertonRichard M HopkinsKatrin HoffmannNeville W Knuckey Tags: arginine-rich peptides cell-penetrating peptides endocytosis neuroprotection poly-arginine stroke Source Type: research

Neural and hemodynamic responses to optogenetic and sensory stimulation in the rat somatosensory cortex
Seong-Gi Kim (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Bistra IordanovaAlberto L VazquezAlexander J PoplawskyMitsuhiro FukudaSeong-Gi Kim Tags: CBF CBV forelimb stimulation neurovascular opto-fMRI Source Type: research

The effects of capillary transit time heterogeneity (CTH) on brain oxygenation
N Jespersen (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Hugo AngleysLeif ØstergaardSune N Jespersen Tags: capillary transit time heterogeneity CBF Michaelis–Menten microcirculation neurovascular coupling oxygen transport Source Type: research

Glucose and oxygen metabolism after penetrating ballistic-like brain injury
ortella & M Ross Bullock (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 11, 2015 Category: Neurology Authors: Shyam GajavelliShimoda KentaroJulio DiazShoji YokoboriMarkus SpurlockDaniel DiazClayton JacksonAlexandra WickWeizhao ZhaoLai Y LeungDeborah ShearFrank TortellaM Ross Bullock Tags: 2-deoxy glucose cerebral metabolism Fluorojade B neurodegeneration oxygen Source Type: research

Lasting pure-motor deficits after focal posterior internal capsule white-matter infarcts in rats
nk Ayata (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 4, 2015 Category: Neurology Authors: Francesco BlasiMichael J WhalenCenk Ayata Tags: endothelin-1 internal capsule motor deficits stroke white matter Source Type: research

Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species
Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species Journal of Cerebral Blood Flow & Metabolism advance online publication, February 4 2015. doi:10.1038/jcbfm.2015.1 Authors: Alberto Julio-Amilpas, Teresa Montiel, Eva Soto-Tinoco, Cristian Gerónimo-Olvera & Lourdes Massieu (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - February 4, 2015 Category: Neurology Authors: Alberto Julio-AmilpasTeresa MontielEva Soto-TinocoCristian Gerónimo-OlveraLourdes Massieu Tags: energy failure hypoglycemia ketone bodies neuronal death oxidative stress Source Type: research